Posted by admin on Nov 30, 2019 in |
Osteomyelitis is a very serious disease caused by bacteria, especially Staphylococcus aureus, which directly attacks the bones tissues. Many physicians and surgeons are still looking for the basic cure of the disease. This article mainly focuses on the different kinds of treatments using new drug formulations. Vancomycin coated with chitosan polymers, biodegradable scaffolds, use of major limb amputations with a modified Lautenbach technique, and use of telavancin drug for outpatients is currently used for the treatment of osteomyelitis. Osteomyelitis is classified based on the cause of the disease and also the treatment. Many research works have been carried out which gives us prospects for the treatment of the disease. The pros and cons associated with different methods used for the treatment of the disease are discussed. These methods give us a better idea about the treatment of the disease and also helps in restricting the disease without causing larger damage. The usage of PMMA beads has shown better results for the treatment of Chronic...
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Posted by admin on Nov 30, 2019 in |
Hyperhomocysteinemia is a metabolic catastrophe characterized by an elevated level of homocysteine above 15 mmol/L in blood. It is an established risk factor for cardiovascular anomalies. The illness has also crucial impact on other organs and tissues of body. Its morbid effects have been seen during many chronic conditions. It is also considered as a metabolic crunch during gestation as well as geriatric conditions. Increased homocysteine has also been seen to play a critical role and key factor in development of many health issues including stroke, cancer, and neurodegenerative diseases. Although, it is an autosomal recessively inherited defect, but can also be developed during intake of vitamin deficient high protein diet. This illness causes many ill effects on our vital organs and becomes a risk factor for several health complications such as venous thrombosis and vascular damage. The existing treatment includes vitamin B12, B6, and folic acid, but based on the mechanism of this disease methyl donor substance (natural product or synthetic moiety) may also be utilized in order...
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Posted by admin on Nov 30, 2019 in |
Recent past has witnessed the promising roles of natural gums as pharmaceutical ingredients. Gums became important excipients in many pharmaceutical preparations owing to their abundance, biodegradability, non-toxicity and comparatively low cost. They have notable applications in pharmaceutical preparation as binders, disintegrants, suspending agents, emulsifiers. The use of these gums as gelling or matrix-forming agents to suit the requirement as excipient in novel drug delivery systems is one of the interesting fields of emerging research. The present article is focused on reviewing some important features of gums, their economic importance uses and pharmaceutical...
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Posted by admin on Oct 31, 2019 in |
Rubella is an eradicable illness on the grounds of immunization against it produces solid protection. The name rubella comes from the Latin language, and it means “little red”. In olden times people thought that rubella was a variant of measles. German literature first described it as a separate disease, and hence it was also called “German Measles”. People are the main reservoir of the infection. Before inoculation, rubella was endemic around the world, with plagues occurring every 6-9 years. Congenital rubella syndrome (CRS) acquires a very important place in rubella infection since it leads to a highly damaging effect on the health of newborns. It is transmitted to them by their mothers who have acquired this infection. Babies conceived every year with inborn rubella disorder is a disaster. Although, effective vaccination programs against rubella, especially in combination with immunization against measles has led to the eradication of this disease especially in developed countries like United States of America, still it is vital to recollect that having a powerful antibody...
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Posted by admin on Oct 31, 2019 in |
Alloxan diabetes mellitus (DM) simulates acute metabolic stress in a different direction, whose starting point is primary lysis of β-cells in the pancreas. Disorders in the system of the major insulin-induced regulatory mechanism occur, initiating imbalance in the system of a living organism generally. Primary changes occur on the level of metabolic ways of the cells of the pancreas and liver: redistribution of mitochondrial and microsomal processes of oxidation with possible synthesis of new isoenzymatic forms of important metabolic enzymes, disturbance of synthesis of regulatory proteins and, as a result, degenerative changes in the cellular structure (lysis, necrosis and apoptosis). Despite the numerous and even contradictory points of view, the theory of cell lysis with the increase of transaminases activity is still predominant. Cytolytic syndrome leads to the destruction of liver cells, the concentration of serum GOT increases dramatically (probably due to the mitochondrial fraction). Under conditions of alloxan-induced diabetic rat model intensification of oxidative stress processes occur provoking changes, which are typical for chronic hepatitis. Alloxan diabetes serves...
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