Posted by admin on May 31, 2020 in |
In many aspects, polymeric materials have a pre-eminent position among excipients as they form the backbone of modern pharmaceutical formulations and drug delivery technologies in particular. A polymer is a natural, semi-synthetic or synthetic substance that is combined with a drug or other active pharmaceutical ingredient or excipient to release the drug in a pre-programmed manner. The drug delivery system focuses particularly on the enhancement of bioavailability, site-specific release, mucoadhesive release, sustained release, controlled release, targeted release. For achieving different release patterns as mentioned above different types of polymers are needed. Though there are various natural semi-synthetic and synthetic polymers available Eudragit polymers always have special consideration during polymer selection as it can offer a variety of grades which are useful during product development for any of the above-mentioned purpose. This article reviews Eudragit polymers in terms of usefulness during pharmaceutical applications. Eudragit polymers that are chemically Polymethacrylates are synthetic cationic, anionic and non-ionicpolymers of dimethyl-aminoethyl methacrylates, methacrylic acid and methacrylic acid esters in varying ratios. Eudragit polymers play...
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Posted by admin on Apr 30, 2020 in |
Chalcones are naturally occurring compounds with a wide range of biological activities along with an anticancer activity through various mechanisms. It is also known as aromatic ketone, which creates a central core for different essential biologically active compounds. The literature on anticancer chalcones shows the use of various prolonged approaches like structural manipulation and replacement of both aryl rings, molecular hybridization by combination with other pharmacological important moieties to enhance anticancer characteristics. Methoxy substitution on both the chalcones A and B aryl rings based on their position in the aryl rings, usually affect anticancer and other activities. Additionally, chalcones affect the anticancer activity proven through the various categories of compounds. Hybrid chalcones developed by chemically linking chalcones to other leading anticancer scaffolds such as benzodiazepines, imidazole, benzothiazole have proved complementary or intrinsic pharmacological behavior. This study summarizes the concerted attempts made in the design and growth of anticancer chalcones reported in the latest literature and also gives an overview of recently released...
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Posted by admin on Apr 30, 2020 in |
Chronopharmacology is the science that is of different types in the pharmacological activities of different treatment over organic timings and endogenous balance. Chronotherapeutics is the science which increases the creativity and security of prescriptions by balancing their fixations during the 24 h synchronizing with regular routine determinants of disease. Chronopharmacokinetics again manages time and predictable changes in pharmacokinetic parameters of medicines. For example manages the examination of the fleeting changes in the assimilation, dissemination, digestion, and disposal because of the time of planning of the treatment. Circadian rhythms are especially notable in drugs. Biologic rhythms are the endogenic nature of circadian. Chronopharmaceutics is depicted as a part of pharmaceutics gave to the plan and evaluation of medication prescribing structure that discharges a bioactive specialist at a musicality that preferably coordinates the natural prerequisite of given disease treatment. The fresher treatment conveyance structure that is structured with the chronopharmacological approach holds incredibly long for conveying better patient consideration regarding viability, resistance, and wellbeing parameters of the...
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Posted by admin on Apr 30, 2020 in |
Taxol is an important drug used for the treatment of various types of cancer. It is primarily obtained from Taxus brevifolia bark and has a long history of the developmental program of 50 years. It functions as a microtubule-stabilizing compound and inhibits mitosis of cancer cells, thereby providing a protective role in the treatment of cancers. In addition to it, taxol also interferes with a number of biochemical pathways and protein to bring about apoptosis and cell death. Since its inception, taxol has undergone various levels of modifications and formulations with a motive of making its action more effective. This has led to the development of Paclitaxel by Bristol-Myers Squibb for large scale commercialization. Consequently other semi-synthetic variants such as Docetaxel and Cabazitaxel were also developed for better actions. All these compounds are collectively called as Taxanes and contain a common ringed baccatin III structure in its molecule. This review is an attempt to illustrate the gradual development of anticancer taxanes from its precursor Taxol and its various pharmacological...
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Posted by admin on Apr 30, 2020 in |
Type 2 diabetes mellitus (T2DM) is a chronic disease, and most patients ultimately require two or more anti-hyperglycemic drugs along with lifestyle changes to achieve and maintain glycaemic control. Sodium-glucose co-transporter 2(SGLT2) inhibitors, such as Dapagliflozin, are the newest class of antidiabetic drugs approved for the treatment of T2DM. Dapagliflozin is a highly selective SGLT2 inhibitor that decreases glucose reabsorption by kidneys and thus lowers blood glucose by increasing glucose excretion in urine output. Dapagliflozin effectively improves glycaemic control by increasing the renal excretion of excess glucose. In clinical trials, dapagliflozin has been well-tolerated and safe to be administered to the major population. It has additional benefits of weight loss, low risk of hypoglycemia, reduction in blood pressure, and cardiovascular benefits. Dapagliflozin can be administered as monotherapy on in combination with other antidiabetic drugs. Thus, Dapagliflozin offers a novel treatment option for type 2 diabetes mellitus with additional...
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