Posted by admin on Feb 29, 2020 in |
Lung cancer is a malevolent lung growth characterized by unrestrained cell expansion in tissues of the lung. EGFR is occupied dissimilar fundamental presentation of cancer cells that includes expansion of cells, enlargement, propagation, apoptosis regulation etc. make it a prime objective for lung cancer. EGFR is a tyrosine kinase inhibitor that is proposed in epithelial cells. EGFR inhibitors are drugs that connect to firm parts of EGFR and stop the expansion of cells. Till date, EGFR inhibitors are classified into two categories first one is tyrosine kinase inhibitor and the second one is monoclonal antibodies. Tyrosine kinase inhibitor binds to the area of tyrosine kinase in the epidermal growth factor receptor and hinders the activity of EGFR. Monoclonal antibodies bind to the extracellular components of EGFR prevent it to bind with its own receptor so that stop cell division. This review encompasses complete updates on a generation of epidermal growth factor receptor tyrosine kinase inhibitor used in the treatment of non-small cell lung...
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Posted by admin on Feb 29, 2020 in |
Despite years of intensive research, impairment in metabolic pathways due to type 2 diabetes mellitus continues to be a daunting global challenge. It is equally challenging problem in this region as well. In recent years there is growing clinical and experimental evidence that oxidative stress plays an important role in induction and promotion of diabetes and its associated complications. Lipid peroxides are known to be essential consequence of biological processes of excessive oxidative cellular damage can be a cause of consequences of numerous diseases, micro and macro complications of type 2 diabetes mellitus. There have been reports of elevated lipid peroxide levels in type 2 diabetes. To defend themselves against these free radical attacks, cell has developed different antioxidant systems. There are low molecular weight antioxidant molecules like uric acid, ascorbic acid, etc. and antioxidant enzymes superoxide dismutase, catalase and glutathione peroxidases. Under physiological conditions, these defense mechanisms maintain a low steady-state concentration of free radicals in the cell and their activities are very precisely regulated. The levels of...
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Posted by admin on Feb 29, 2020 in |
Bacteriophages are particular infective agents of diverse bacteria. They are separated into different groups according to their life cycle. The lytic phages kill their host cells; this property can be applied for the selective elimination of pathogenic bacteria. The first bacteriophage treatment was described one hundred years ago, and phage therapy had been extensively used until the Second World War. Upon the appearance of antibiotics, the medical application of phages retrograded in most parts of the world. In the last decades, owing to the costs of development of new antibiotics and the rapid emergence of multidrug-resistant bacteria, this old approach was revitalized and phage-based treatment was legalized from the middle of the last decade. Here, they summarize the current knowledge on phage therapy, its advantages and potential drawbacks. The current status of phage therapy against food-borne, animal and human pathogens is also presented. Among these, special focus is set on phages E. Amy of Staphylococcus aureus, Salmonella typhimurium and Listeria monocytogenes. Phage cocktails against Listeria monocytogenes and E. amylovora...
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Posted by admin on Feb 29, 2020 in |
The aim of a pharmaceutical product is to obtain excellent therapeutic and favorable treatment. Controlled drug release coatings have been around for more than 50 years and their performance has increased significantly since the beginning. The main drawbacks of the controlled drug delivery system are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. To overcome this disadvantage, the researcher focused on controlled drug delivery system Injectable hydrogels. It is an emerging trend in the field of biomaterial drug delivery systems. Injectable Hydrogel overcomes the limitation of a pre-formed hydrogel, as they are injected with minimum invasive procedure into target sites and used for irregularly shaped sites. The recent studies of injectable hydrogels for the drug delivery applications suggested that multi-functional injectable hydrogels are capable of entrapping and systematically delivering the multiple therapeutic agents like drugs and macromolecules. The Injectable hydrogel shows shear thinning property when injected into the body. In this review, various aspects of Injectable hydrogel like introduction, Properties,...
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Posted by admin on Feb 29, 2020 in |
The oral route of drug administration is one of the simplest route of drug administration throughout the world because its patients convenience. The drug administered through orally should possess good aqueous solubility for better oral absorption and thus bioavailability will increase. But it was found that 30-40% of the drug shows low solubility thus bioavailability profile will be affected. Self-emulsifying drug delivery (SEDDS) system is a novel therapeutic drug delivery system of those new drugs whose aqueous solubility is very poor. Thus, by this delivery system the new drugs can be administered to the body via oral route and hence therapeutic effect will be desired appropriately. The most unique feature of this delivery system can form oil in water emulsion when diluted in an aqueous phase. Thus, this delivery system enhances the rate and extent of drug or absorption when given by oral route. The cost of this delivery system is affordable as it can consist natural oil and common excipients. Thus, large scale production is also possible for...
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