Posted by admin on Dec 31, 2019 in |
PTEN (phosphatase and tension homolog deleted on chromosome 10) is an important key factor in regulating intracellular for cell growth and proliferation by blocking the phosphatidylinositol -3kinase/ AKT protein kinase B (PI3K/Akt) pathway alteration in PTEN is concomitant with many diseases. PTEN is recurrently mutated in several pathological diseases which indicate its significance in general physiological activity. Various cellular proteins are initiated by phosphorylation; in contrast, PTEN is deactivated based on phosphorylation by specific kinases. Therefore, the development of therapeutic agents includes selectively targeting quickness and kinase-domain containing proteins affecting PTEN associated diseases. The present review focuses on the role of PTEN in pathological conditions and a comprehensive list of currently identified modulators of PTEN and explains potential new molecular targets which could be help in the development of drugs for the management of PTEN associated diseases like cardiovascular diseases, diabetes, obesity, cancer, autism, and Alzheimer’s...
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Posted by admin on Nov 30, 2019 in |
Cancer is a genetic disorder that can happen to anybody; anytime. The treatment, where one or more chemotherapeutic agents (anti-cancer drugs) are used either to treat the cancer patients (curative intent with one or combination of anti-cancer drugs) or to prolong the life and to reduce the symptoms in cancer patients is known as Chemotherapy. But nowadays it is observed that when these chemotherapeutic agents are administered in the cancer patients for prolonged period then the drugs stop showing the required response and thus results in the failure of the treatment. This is called Multiple Drug Resistance (MDR). Various treatments are coming up recently, and combination therapy of chemotherapeutic agent and chemosensitizer molecule is one of the effective approaches to combat the Multidrug Resistance of anti-neoplastic drugs in cancer cells. This paper reviews MDR associated with cancer, therapies to overcome the resistance and studies to confirm the...
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Posted by admin on Nov 30, 2019 in |
Introduction: Juvenile idiopathic arthritis (JIA) is chronic inflammatory arthritis in children and adolescents. The symptoms present in JIA are more comparable with features of Aamavata Vyadhi mentioned in Ayurvedic classics. JIA can be treated by Shodhana and Shaman therapy of Ayurveda which is free from any side effects. The main aim of this article is to elaborate on JIA and its treatment by different modalities of Ayurveda. Methodology: This review work was carried out by using a widespread and planned data mining approach. To achieve significant literature author uses the keywords “Juvenile idiopathic arthritis” “Shodhana therapy in JIA” “JIA treatment by Ayurveda” and “herbal medicine for JIA” searched in Google Scholar, web of science, Science direct, Scopus, Medline, and PubMed Central journal literature. Observation: Nine publications were included in the final selection after systematic analysis. Conclusion: In Ayurveda, Shodhna therapy such as Sarvaanga Abhangya (Full body massage with medicated oil), Nadi swedana (Steam bath), Valuka Swedana (fomentation by sand pack) and Vaitarana Basti (type of medicated enema) is very...
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Posted by admin on Nov 30, 2019 in |
This paper is to review the green catalytic synthesis of organic reactions and discussed its advantages over the conventional method of synthesis. Recent advanced technologies have key trend to reduce the negative impacts of chemical environment and helps to obtain sustainability in chemical production. This review tries to bring many catalytic techniques that are safer in nature and more economical. We have considered those synthetic schemes which have significant role in pharmaceuticals industry and the different green catalyst employed in those reactions. These organic reactions have special advantages with the use of catalyst; there is better utilization of starting materials and minimum waste product formation. The main objective of these synthetic schemes is that there is least pollution to the...
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Posted by admin on Nov 30, 2019 in |
Antibiotic is the powerful invention of science to damage bacterial infections. But nowadays, the use of careless increasing doses of this antibiotic has led to increasing the resistant power of enemy bacteria. Bacteria are caused by many infectious diseases by proliferation within quorum sensing (QS) mediated biofilms. Quorum sensing can develop microbial pathogenic traits, including biofilm formation. Try to smash biofilms have led the identification of bioactive molecules evolved by prokaryotes and eukaryotes. The activity of these bioactive molecules is done by quenching the QS systems. For this reason, we need to inhibit quorum sensing, which may be done by various types of inhibitors called quorum sensing inhibitors (QSI). Synthetic and natural QSIs plays a vital role to inhibit QS. In this review, some examples of QS inhibitors like synthetic and natural based QS inhibitors are highlighted. This review is also focused on the inhibition of QS mechanisms and the application of QSI in various...
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