Posted by admin on Jun 30, 2019 in |
Breast cancer (BC) is the foremost cause of deaths among women worldwide. Plants contain diverse bioactive phytochemicals which have been explored by researchers all over the world for their cancer preventive potential. The present review tabulates in-vitro tested plants during 2014-17 against breast cancer cell line. We have collected data of 56 angiosperm families (117 plant species) which was subjected to cluster analysis. On the bases of IC50 values of plant extracts were clustered using cluster analysis Cluster analysis showed a grouping of order Brassicales, Fabales, Lamiales, Caryophyllales, Myrtales, and Apiales. It has been found that most of the plants tested against BC belong to eudicot group of plants. Active plant extract obtained after 24 h, 48 h and 72 h treatment were Mimosa caesalpinnifolia, Ferulago angulat, Magydaris tomentosa, and Ipomea batatas respectively. These plants may further be characterized for active ingredients to check their prospects in breast cancer...
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Posted by admin on May 31, 2019 in |
Plasmodium knowlesi, a simian malaria parasite, is widely used as a malaria model and now characterized as a clinically significant parasite that can lead to outbreaks throughout most countries in Southeast Asia. Despite its importance, both fundamental and clinical studies of P. knowlesi have been impeded by the lack of a convenient in-vitro culture system partly due to the parasite’s preference for reticulocytes. Due to a limited number of reticulocytes that could be collected from fresh sources such as umbilical cord, bone marrow, and peripheral blood, scientists have opted reticulocytes generated from CD34+ hematopoietic stem cells (HSCs) that have been cultured in an in-vitro system. With sufficient growth factors (GFs) and differentiation factors (DFs), a higher number and more homogenous populations of reticulocytes could be obtained from HSCs in-vitro. Here, we review an approach to produce massive expansion of CD34+ HSCs and their differentiation into reticulocytes that could be used for the establishment of a continuous in-vitro culture of P. knowlesi or P. vivax. The successful development of the...
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Posted by admin on May 31, 2019 in |
Dapagliflozin (DAPA) is a drug of gliflozin class. It is a white crystalline solid. Dapagliflozin is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity. Dapagliflozin blocks glucose reabsorption into the kidney, resulting in the elimination of blood glucose through the urine. DAPA is not official in any pharmacopeia. It comes under EU Pharmaceutical Product Classes, as per literature survey. Till date officially no analytical method has been developed or reported for this drug. This review focuses on collective literature on the analytical methods developed for...
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Posted by admin on May 31, 2019 in |
The fruit of Terminalia chebula is an essential drug used in single and in many compound formulations of Indian traditional systems like Ayurveda & Siddha and Unani systems of medicine. This herbal drug is referred to as ‘The king of medicines’ which denote it’s efficacy and potency in treating diseases. The TCF is the richest source of phenols among other plants and is cherished with lead active ingredients with high scope for drug discovery for a spectrum of diseases because of the five tastes except for the salty taste in it. As global acceptance of traditional drugs increase in the past decades, compliance with the quality in terms of standard parameters and regulatory laws on the drugs also are sharpened. Drugs of poor quality degrade the clinical efficacy and also create a query on safety concerns. Authentication of a drug to be a genuine variety is of prime importance in standardization. Terminalia sps. are numerous. Seven types of medicinally useful TCFs are mentioned by the Siddhar (sage) Agathiyar based...
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Posted by admin on May 31, 2019 in |
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders in the population above 60 years of age. The movement abnormalities in PD are credited due to an imbalance between the acetylcholine and dopamine which results in uncontrolled movements. It is characterized using resting tremor, postural impairment, bradykinesia, and rigidity. The degeneration of midbrain dopaminergic neurons and accumulation of inclusions containing α-synuclein (termed “Lewy bodies”) throughout the nervous system are few of the most prominent features of PD. Still, there is no cure; we have several management options for the early treatment of PD. Several objective methods have been proposed for improving the diagnostic accuracy of PD, for enabling earlier diagnosis, to quantify the severity of disease and progress of treatment given. These methods include motor performance tests, olfaction tests, imaging techniques, and biochemical tests of blood and cerebrospinal fluid. None of the proposed methods is widely available or clinically used for PD. The validation of the objective methods takes time, and a large number of regulatory requirements...
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