Posted by admin on Nov 30, 2019 in |
Schizophrenia is a chronic and severe mental disorder that affects how a person thinks, feels, and behaves. People with schizophrenia may seem like they have lost touch with reality. Schizophrenia is a split personality disorder which is related to mental illness. Generally, schizophrenia affects approximately 1 percent of all adults’ population. Schizophrenia is different types such as paranoid in which auditory hallucinations occur, some time disorganized schizophrenia occurs in which disorganized speech and behavior are shown. The hypothesis of schizophrenia included dopamine hypothesis, glutamatergic hypothesis, GABAergic hypothesis. Pharmacologically, they are characterized as dopamine receptor antagonists, though many of them also act on other targets, particularly 5-hydroxytryptamine (5-HT) receptors. The antipsychotic agents are used for the treatment of schizophrenia. Based on pharmacologic action, the chemical structures of antipsychotic agents contain reserpine- like compounds, phenothiazines derivatives and compounds include various tricyclic derivatives with a central 7-membered ring to which methyl piperazine is linked. The activity of this group is widely scattered, containing among the weakest and more potent of the apomorphine...
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Posted by admin on Nov 30, 2019 in |
Inflammation is the vascular event shown by the body against the external material by activating different cells and releasing various chemical mediators to prevent noxious effects. Many drugs like steroidal and non-steroidal drugs are available till the date to treat inflammation but have a number of side effects and centralized on to counteract the COX and LOX pathways. This perspective will use to search for new drugs that can work to target other pro-inflammatory mediators involve in inflammation and act as target for the inhibition of inflammatory processes and minimize the side effects. The therapeutic targets are any proteins, receptors, pro-inflammatory mediators or enzymes that can be involved in the inflammatory reaction. The targeted therapy acts on it and inhibits targets to combat the inflammation. The recent study assembles the data on novel targets and future anti-inflammatory drugs and the best treatment for incurable inflammatory...
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Posted by admin on Nov 30, 2019 in |
The skin is the largest organ of the human body and easily accessible. It’s potential as an alternative route for administering drugs for both systemic and local effects has attracted considerable interest. Most of the topical medications which are applied on the skin or mucous membrane to treat ailments include a wide range of creams, foams, gels, lotions, ointments, eye drops, ear drops, etc. Topical drug delivery provides a convenient and effective system for the treatment of local pathological conditions (dermal drug delivery) or as the site for systemic drug administration (transdermal drug delivery). Nanostructured Lipid Carriers (NLCs) are drug-delivery systems composed of both solid and liquid lipids as a core matrix. It has been shown that NLCs exhibit several advantages for drug therapy over conventional carriers including increased solubility and stability, improved permeability and bioavailability, reduced adverse effects, prolonged half-life, and tissue-targeted delivery. NLCs have attracted expanding scientific and commercial vigilance in the last couple of years as alternate carriers for the pharmaceuticals. A new generation of NLCs...
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Posted by admin on Nov 30, 2019 in |
Osteomyelitis is a very serious disease caused by bacteria, especially Staphylococcus aureus, which directly attacks the bones tissues. Many physicians and surgeons are still looking for the basic cure of the disease. This article mainly focuses on the different kinds of treatments using new drug formulations. Vancomycin coated with chitosan polymers, biodegradable scaffolds, use of major limb amputations with a modified Lautenbach technique, and use of telavancin drug for outpatients is currently used for the treatment of osteomyelitis. Osteomyelitis is classified based on the cause of the disease and also the treatment. Many research works have been carried out which gives us prospects for the treatment of the disease. The pros and cons associated with different methods used for the treatment of the disease are discussed. These methods give us a better idea about the treatment of the disease and also helps in restricting the disease without causing larger damage. The usage of PMMA beads has shown better results for the treatment of Chronic...
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Posted by admin on Nov 30, 2019 in |
Hyperhomocysteinemia is a metabolic catastrophe characterized by an elevated level of homocysteine above 15 mmol/L in blood. It is an established risk factor for cardiovascular anomalies. The illness has also crucial impact on other organs and tissues of body. Its morbid effects have been seen during many chronic conditions. It is also considered as a metabolic crunch during gestation as well as geriatric conditions. Increased homocysteine has also been seen to play a critical role and key factor in development of many health issues including stroke, cancer, and neurodegenerative diseases. Although, it is an autosomal recessively inherited defect, but can also be developed during intake of vitamin deficient high protein diet. This illness causes many ill effects on our vital organs and becomes a risk factor for several health complications such as venous thrombosis and vascular damage. The existing treatment includes vitamin B12, B6, and folic acid, but based on the mechanism of this disease methyl donor substance (natural product or synthetic moiety) may also be utilized in order...
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