Posted by admin on Feb 28, 2019 in |
Drug as such, may not show the desired therapeutic effect; drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiasis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colon targeted drug delivery system (CTDDS) can deliver drugs as both local and systemic. Local delivery, in the treatment of inflammatory bowel disease (IBD). Treatment could be enhanced when drug delivered to the target site on the colon. Systemic side effects could also be reduced. Colon-specific systems are the most important delivery of those drugs which are normally inactivated in the upper parts of the gastrointestinal tract (GIT). Primary approaches for CTDDS (Colon Targeted Drug Delivery System), which includes prodrugs, pH and time-dependent systems, bacterial enzyme dependent colonic DDS and pH and bacterial enzyme dependent colonic DDS. The...
Read More
Posted by admin on Feb 28, 2019 in |
Lyotropic liquid crystalline systems, such as reversed bicontinuous cubic phases acquire progressive attention because of their unique microstructure and physicochemical properties. Cubosomes were nanostructured liquid crystalline particles, formed from a certain group amphiphilic lipids in definite proportions in water and was stabilized with a triblock copolymer. Substances in use were biocompatible. Cubosomes are curved bicontinuous lipid bi-layers which were organized in three-dimensional structures resembling honeycomb-like structure with distinct amphiphilic, hydrophilic and hydrophobic regions. They serve as a carrier in drug delivery for various bioactive molecules such as chemicals, drugs, peptides, and proteins to protect them from hydrolysis, oxidation or any other way of degradation. Furthermore, several studies have demonstrated the benefits of cubosomes in nanoparticle drug delivery, sustained release, controlled release, and also to provide improved bioavailability. This article gives an overview of initial work that took advancements till drug delivery, cubosomes types, structure, methods of preparation and primarily the applications of cubosomes in the formulation from the past in various categories drugs and...
Read More
Posted by admin on Feb 28, 2019 in |
Inflammatory bowel disease (IBD) refers to the inflammation of the colon and small intestine of the body, in which Crohn’s disease and ulcerative colitis are the principal types of IBD. This article covers most of the information related to a drug delivery system for treatment regarding intestinal diseases more emphasized to inflammatory bowel diseases. Currently, using delivery systems for targeting drugs to colon are osmotic drug delivery system, chronotropic system, pulsinicap system, multiparticulate system, port system, COLAL-Pred system, gas empowered drug delivery system have included in this article. An approach for targeting drugs to the colon is a probiotic approach has also included in this article. These delivery systems are being used to improve the bioavailability of the poorly absorbed drug. The purpose of this review article is to study about techniques employed in colon targeting for the prevention and treatment of...
Read More
Posted by admin on Feb 28, 2019 in |
Alzheimer disease (AD) is the most common cause of dementia which affects more than 44 million individuals worldwide. It has been noticed that there is only symptomatic treatments are available to treat AD, but no cure exists. It is a neurodegenerative disease characterized by Alois Alzheimer’s in 1906, and neuro-degenerative diseases are one of the major concerns facing by the modern health care system. It is a multifarious complex disease which pathology not clearly understood but it is generally characterized by neuronal damage, memory dysfunction, etc. main pathological hallmark factor for Alzheimer disease is deposition of amyloid-β (Aβ) plaques around the neurons, neurofibrillary tangles, and a decrease in acetylcholine concentration and some other neurotransmitter dysregulation. Different types of risk factors like oxidative stress, obesity, diabetes, hypertension, air pollution, smoking, hyper cholesterolemia etc. have a very significant role in the development of AD and in the development of its preventive measures. Physical exercise and nutritional factors have been shown as protective measures for it and help in its prevention. For...
Read More
Posted by admin on Feb 28, 2019 in |
Drug discovery and development plays a major role in the world and serves mankind. The major criteria to be considered and given importance in drug development is the solubility of a drug. Among all newly discovered chemical entities, about 40% of drugs fail to reach the market due to their poor aqueous solubility or lipophilicity. Poor solubility is not only a problem for formulation development and clinical testing but also an obstacle at the very beginning while screening new compounds for pharmacological activity. Nowadays oral route is considered as the preferred route of drug administration than other routes due to its convenience in terms of ease of administration and economy. The first requirement of drug which is supposed to be given by oral route is good aqueous solubility, as the poor solubility leads to low absorption, inadequate and variable bioavailability and also gastrointestinal mucosal toxicity. To prevent these crisis, several solubility enhancement techniques have been employed to enhance the solubility of poorly soluble drugs and hydrotropic solubilization is one...
Read More
