Posted by admin on Jun 30, 2019 in |
Benzothiazole derivatives have a wide interest because of their diverse biological activities and clinical use. This bicyclic compound consists of a fusion of benzene nucleus with a five-membered ring comprising nitrogen and sulphur atoms. It is a vital Pharmacophore and privileged structure in medicinal chemistry and exhibits various useful therapeutic activities such as anti-tubercular, antimicrobial, antimalarial, anticonvulsant, anthelmintic, anti-inflammatory, anti-tumor, anti-diabetic, analgesic, neurodegenerative disorders, local brain ischemia, and central muscle relaxant activities. Moreover, it can be easily found in a range of marine or terrestrial natural compounds that have tremendous biological activities. Benzothiazoles have a promising biological profile and are easy to access which makes this pharmacophore an interesting molecule for designing new bioactive benzothiazole...
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Posted by admin on Jun 30, 2019 in |
Dementia is a cognitive decline which interferes with normal psychological functioning and behavioral patterns. Dementia is as a group of neurodegenerative diseases, which affects about 1 to 4% of the world’s population over 65 years old. Several aetiologies are involved in the pathogenesis of dementia. Patient suffering or suffered from cardiovascular diseases (like hypertension, hypercholesteremia, diabetes, cerebral ischemia, and stroke) and neurodegenerative disorders are more vulnerable to dementia. Other factors like alcohol consumption and smoking further exacerbate this neurodegenerative disorder. Most common forms of dementia are Alzheimer’s dementia, vascular dementia, frontotemporal dementia, semantic dementia and dementia with Lewy body. Alzheimer’s dementia and dementia with Lewy bodies are more common in the elderly. Vascular dementia (VaD) is the second most common form of dementia after Alzheimer’s dementia (AD), which may precipitate as a result of long term CVS diseases. Semantic dementia involves a progressive decline in semantic memory (knowledge of objects, people, concepts and words). In Lewy body dementia (LBD), aggregation of α-synuclein inhibits the neuronal development and plays a...
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Posted by admin on Jun 30, 2019 in |
Macrotyloma uniflorum (Lam.) Verdc. also known as horse gram or Kulthi bean has been an underutilized legume crop with immense medicinal importance/potential. It is considered as a rich source of protein, vitamins, and minerals. It is characteristically known for its biotic and abiotic resistance, e.g., resistant to drought, salt, and insects. There are umpteen references available in the traditional medicinal system reverberating its medicinal significance. Its various bioactivities like anti-diabetic, analgesics, anticalcifying, anti-hypercholesterolemic, anti-obesity, antihelmintic, antioxidant, larvicidal and anorectic properties have already been reported. Despite being both sturdy and nutritive food crop, its consumption is very low. The present review attempts to compile medicinal uses of this crop to attract the people for its consumption. Its regular consumption not only adds to health benefits but also provides useful...
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Posted by admin on Jun 30, 2019 in |
Breast cancer (BC) is the foremost cause of deaths among women worldwide. Plants contain diverse bioactive phytochemicals which have been explored by researchers all over the world for their cancer preventive potential. The present review tabulates in-vitro tested plants during 2014-17 against breast cancer cell line. We have collected data of 56 angiosperm families (117 plant species) which was subjected to cluster analysis. On the bases of IC50 values of plant extracts were clustered using cluster analysis Cluster analysis showed a grouping of order Brassicales, Fabales, Lamiales, Caryophyllales, Myrtales, and Apiales. It has been found that most of the plants tested against BC belong to eudicot group of plants. Active plant extract obtained after 24 h, 48 h and 72 h treatment were Mimosa caesalpinnifolia, Ferulago angulat, Magydaris tomentosa, and Ipomea batatas respectively. These plants may further be characterized for active ingredients to check their prospects in breast cancer...
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Posted by admin on May 31, 2019 in |
Plasmodium knowlesi, a simian malaria parasite, is widely used as a malaria model and now characterized as a clinically significant parasite that can lead to outbreaks throughout most countries in Southeast Asia. Despite its importance, both fundamental and clinical studies of P. knowlesi have been impeded by the lack of a convenient in-vitro culture system partly due to the parasite’s preference for reticulocytes. Due to a limited number of reticulocytes that could be collected from fresh sources such as umbilical cord, bone marrow, and peripheral blood, scientists have opted reticulocytes generated from CD34+ hematopoietic stem cells (HSCs) that have been cultured in an in-vitro system. With sufficient growth factors (GFs) and differentiation factors (DFs), a higher number and more homogenous populations of reticulocytes could be obtained from HSCs in-vitro. Here, we review an approach to produce massive expansion of CD34+ HSCs and their differentiation into reticulocytes that could be used for the establishment of a continuous in-vitro culture of P. knowlesi or P. vivax. The successful development of the...
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