Posted by admin on Mar 31, 2019 in |
Heterocyclic chemistry plays a very most important role in medicinal chemistry as well as in organic chemistry. Most of the drug molecule formed and possesses therapeutic activity due to the heterocyclic scaffold. A slight change in heterocyclic moiety leads to the major therapeutic change in the drug molecule. Benzothiazole can serve as a unique and versatile moiety for experimental drug design. Benzothiazole and its derivatives are the essential chemical compounds with tremendous application in research area especially in synthetic as well as in pharmaceutical chemistry because of its potent and significant pharmacological activities. As we know that benzothiazole is a combination of two rings six-membered and five-membered and it is also known that both rings are responsible for the therapeutic activity. The main objective of our study is to find what changes lead to a better corrective benzothiazole shift moiety. A well-known approach to design new drug-like molecules, which allows achieving new pharmacological profile, action, toxicity lowering, is the development of a combination of 2- aminobenzothiazoles with another heterocyclic...
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Posted by admin on Mar 31, 2019 in |
About 5-10% of individuals with the condition of prediabetes or intermediate hyperglycemia develop diabetes annually. Prediabetes can revert to normal glycaemic state as well. Reversion to normal glucose, even when transient, is associated with a significant 56% reduced risk of future diabetes independent of previous treatment. Prediabetes is associated with many microvascular as well as macro-vascular complications. Micro-vascular complications include retinopathy, neuropathy, and micro-albuminuria while another complication like heart disease, stroke, and peripheral vascular diseases comes under the macrovascular category. These complications are directly proportional to the succession of hyperglycemia in prediabetes. Detection of the condition prediabetes / intermediate hyperglycemia is a fundamental strategy to keep people from transitioning to diabetes. Lifestyle modification is the mainstay for the management of intermediate hyperglycemia as per various research conducted on the same. The benefit of lifestyle modification with or without pharmacotherapy to prevent or delay the progression of diabetes in patients with prediabetes. When lifestyle modification is ineffective, pharmacologic treatment should be considered although there are no approved pharmacologic treatments for...
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Posted by admin on Mar 31, 2019 in |
Stability of pharmaceuticals is defined as the ability to retain the quality, purity, Identity, and safety throughout the shelf life of products. It is of main concern because drug substance and products lose its Potency and quality after the time passes, due to change in environmental conditions such as temperature, light, and humidity. It is essential that quality of drugs should maintain throw out the life cycle of drug products for their safe and effective use. The need for constant monitoring of the drug substance and product for their quality and purity has the origin of the development of various stability testing methods. Stability testing now becomes a regulatory requirement for filing NDA and ANDA to USFDA and various regulatory agencies. Stability indicating methods had originated from advancement in various analytical instrument technologies. Stability indicating methods of drug substance and products have the ability for separation, identification, qualification, and quantification of all impurities associated with drug substance and drug product at any storage Conditions to give the exact concentration...
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Posted by admin on Mar 31, 2019 in |
Traditional medicine is finding more significance and application today, particularly when we are facing difficulty in the management of numerous medical conditions. More effective and palatable drug dosage forms are needed in the modern era. The recent trend in traditional medicine dosage forms is to enhance the solubility, bioavailability, pharmacological activity, stability, reduce the toxicity and increase the compliance, etc. Oral dosage form which can address these factors are granules (effervescent and rapid release granules), tablets (fast dissolving and rapid disintegrating tablet), capsules, suspension, syrups, etc. and topical dosage form includes toothpaste, natural hair dye, face pack, hand wash, liniment spray and roll-on, gel, creams (emulsion), shampoo, etc. Contemporary, traditional pharmacies including several Ayurvedic pharmacies have already implemented these new trends and launched several new dosage forms apart from traditional under cover of conventional knowledge; few of such Unani products have also been launched. There is an immense need to adopt these recent trends in respect of the dosage form in Unani and another Indian traditional medicine pharmacy for...
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Posted by admin on Mar 31, 2019 in |
To develop a standard conventional solid dosage form like tablets it include the operations involving like milling, mixing, granulation, drying and compression which able to result in different qualities of the final products concerning the loading of the drug, the release of the drug, stability of the drug and pharmaceutical dosage form stability. To overcome some challenges of conventional pharmaceutical unit operations, 3DP is gaining more attention in the pharmaceutical formulation in the future. 3DP can successfully overcome the issues relating to the drug delivery of peptides, potent drugs, water-soluble drugs, and the release of multi-drugs, etc. The ideal opportunity of this technology is the preparation of personalized doses to state individual patient needs. This technology can be seen as the future of solid dosage forms produced on demand, with lower in cost and it also helps in minimizing side effects caused by excessive doses. However, some problems that limit the applications of 3DP in the commercial market, such as selections of binders which are suitable and excipients and...
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