Posted by admin on Feb 28, 2019 in |
In recent times, the use of herbal products has increased tremendously in the developing as well as in developed countries. Bacopa monnieri is one of the most important medicinal plant that has been consumed for thousands of year as a memory enhancing, anti-inflammatory, analgesic, antipyretic, sedative and anti-epileptic agent. For many years, a lot of commercial and medicinal researches have been focusing their resources on this plant. The plant has been known to possess various activities such as, anti-bacterial, anti-fungal, anti-cancer, anti-oxidant, anti-inflammatory, anti-hyperglycemic, anti-depressant, anti-epileptic, memory enhancer, anti-ulcer, hepatoprotective, analgesic, anti-diarrheal, anti-hypertensive, anti-toxicity etc. Therefore step should be taken for its sustainable use and conservation. This review describes the phytoconstituents, traditional uses, and pharmacological activities of Bacopa monnieri. In brief, the biotechnological applications such as tissue culture, elicitation, genetic transformation for the advancement of this plant and its active components production have also been...
Read More
Posted by admin on Feb 28, 2019 in |
Childhood is characterized by periods of rapid growth, maturation, and development. There is a change in the magnitude of the dose required during childhood and adolescence. Thus, Paediatric practice requires a range of dosage forms that are acceptable at different ages and abilities and a range of strengths or concentrations allowing administration of the correct age-related dose. Literature shows that a significant percentage of products suitable for children have inadequate dosing information and the products licensed for children, dosage forms are unsuitable for the intended ages. The development of multiple dosage forms for different ages will rarely be commercially viable and liquid formulations, which can be given to a broad age group, present particular pharmaceutical challenges. However, if there is the commercial incentive of a large market for common illness such as pain or vomiting a complete and varied portfolio of products can be made available. Dispersible drug delivery treatment is one of the breakthroughs that modify the conventional dosage forms (swallowing and chewing) for infants and children. In...
Read More
Posted by admin on Feb 28, 2019 in |
QbD decrees the definition of a goal for the method and accentuates thorough evaluation and scouting of alternative methods systematically to obtain ideal method performance. QbD tools like risk assessment and design of the experiment, empowers better quality to be instilled into the analytical method and facilitate prior understanding and identification of variables affecting the method performance. Analytical quality by design (AQbD) permits the analytical method for movement within a method operable design region. Unlike current methods, analytical method development using AQbD approaches diminishes the number of out of trend results and out of specification results due to the robustness of the method. It is a current inclination among pharmaceutical industry to implement AQbD in method development processes as a part of risk management, pharmaceutical development and pharmaceutical quality systems (ICHQ10). It owes to the lack of explanatory reviews. The objective of this review article is to provide a comprehensive understanding of various aspect of...
Read More
Posted by admin on Feb 28, 2019 in |
Drug as such, may not show the desired therapeutic effect; drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoebiasis, colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colon targeted drug delivery system (CTDDS) can deliver drugs as both local and systemic. Local delivery, in the treatment of inflammatory bowel disease (IBD). Treatment could be enhanced when drug delivered to the target site on the colon. Systemic side effects could also be reduced. Colon-specific systems are the most important delivery of those drugs which are normally inactivated in the upper parts of the gastrointestinal tract (GIT). Primary approaches for CTDDS (Colon Targeted Drug Delivery System), which includes prodrugs, pH and time-dependent systems, bacterial enzyme dependent colonic DDS and pH and bacterial enzyme dependent colonic DDS. The...
Read More
Posted by admin on Feb 28, 2019 in |
Lyotropic liquid crystalline systems, such as reversed bicontinuous cubic phases acquire progressive attention because of their unique microstructure and physicochemical properties. Cubosomes were nanostructured liquid crystalline particles, formed from a certain group amphiphilic lipids in definite proportions in water and was stabilized with a triblock copolymer. Substances in use were biocompatible. Cubosomes are curved bicontinuous lipid bi-layers which were organized in three-dimensional structures resembling honeycomb-like structure with distinct amphiphilic, hydrophilic and hydrophobic regions. They serve as a carrier in drug delivery for various bioactive molecules such as chemicals, drugs, peptides, and proteins to protect them from hydrolysis, oxidation or any other way of degradation. Furthermore, several studies have demonstrated the benefits of cubosomes in nanoparticle drug delivery, sustained release, controlled release, and also to provide improved bioavailability. This article gives an overview of initial work that took advancements till drug delivery, cubosomes types, structure, methods of preparation and primarily the applications of cubosomes in the formulation from the past in various categories drugs and...
Read More
