Posted by admin on Apr 30, 2018 in |
Dietary nitrate has been demonstrated to have a range of beneficial vascular effects, including reducing blood pressure, reduction in pulse wave velocity, regulation of cerebral blood flow, enhancing exercise performance in healthy individuals, stimulating angiogenesis and vasculogenesis etc. Earlier studies with nitrate or nitrite also demonstrate the synergistic effects against ischaemia-reperfusion injury and reduce arterial stiffness, inflammation and intimal thickness. However, there is a need for scientific evidences for hard endpoints beyond epidemiological studies. Although studies have suggested reduction in cardiovascular risk and cancer with diets high in nitrate-rich vegetables but still a lot remains to be elucidated. Moreover various therapeutic effects have reported that the nitrate and nitrite have more affluent biological actions till now, and numerous attempts are currently ongoing for the consideration of potential useful effects in the clinical uses. Here we corroborated a brief data regarding clinical uses of nitrite and nitrate that may serve as potential therapeutic...
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Posted by admin on Apr 30, 2018 in |
Oral modified or controlled dosage forms have always proven to be more effective alternative to conventional or immediate release dosage forms. Controlled or modified drug delivery systems offer numerous advantages of delivering a drug to the body in a précised manner with an aim to minimize its unwanted side effects and maximize its benefits. Targeted drug delivery systems target a particular site in the body to maximize the drug concentration in a specified tissue or organ of the body which improves therapeutic efficacy of the drug, decrease toxicity and with better patient compliance and convenience. In past few decades, microspheres have promised targeted or controlled delivery of drugs in the body which has proved to be better than the conventional drug delivery. Recently microspheres have been used to deliver drugs, vaccines, antibiotics and hormones in a controlled manner. The present study aims to review different aspects of the microparticulate drug delivery system along with types of microspheres, methods of preparation and different applications as targeted or controlled drug delivery...
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Posted by admin on Apr 30, 2018 in |
Tea (Camellia sinensis) is one of the most widely consumed beverages in the world. Tea extracts are source of polyphenols, which are antioxidant components. Green tea phenolic compounds are predominately composed of catechin derivatives, although other compounds such as flavonols and phenolic acids are also present in lower proportion. The main catechin compounds found in green tea are (-) Epigallocatechin Gallate (EGCG), (-) Epigallocatechin (EGC), (-) Epicatechin Gallate (ECG) and (-) Epicatechin (EC) and other compounds. An antioxidant is a molecule capable of inhibiting the oxidation of other molecules. Oxidation is a chemical reaction that transfers electrons from the substance to an oxidizing agent. Oxidation reactions can produce free radicals. A molecule with one or more unpaired electron in its outer shell is called a free radical. Free radicals are formed from molecules via breakage of a chemical bond such that each fragment keeps one electron, by cleavage of a radical to give another radical and, also via redox reactions. In turn, these radicals can start chain reactions that...
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Posted by admin on Apr 30, 2018 in |
Alterative medication and natural remedies have been used from ancient time for the treatment and wellbeing of human. Medicinal plants are considered to be effective and for most important for the human health. Some of the natural medicinal plants are so common that we use them in daily life without knowing their medicinal importance. Annona squamosa belonging to the family Annonaceae is the best example of it. It is a multipurpose tree with edible fruits. Its fruits are commonly known as custard apple which is eatable. The pulp can be used as flavouring in ice cream. Between 50-80% of the fruit is edible. The Vitamin C content is appreciable (35-42 mg/100 g) and slightly higher than in grapefruit. The nutrient value of thiamine, potassium and dietary fiber is also significant. It is reported to contain various chemical compounds such as alkaloid, isomeric hydroxyl ketones from leaf, acetogenin, samaquasine, annonacin and annonastatin from seeds, acetogenin, squamone from bark of it. Various studies have been reported as an antibacterial, antidiabetic, antitumor,...
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Posted by admin on Mar 31, 2018 in |
Aloe vera belongs to the family Liliaceae commonly known as Ghrit Kumari, is the ever known oldest and the most applied medicinal plant worldwide. Aloe Vera is used for vigor, wellness and medicinal purposes since rigvedic times. Health benefits of Aloe vera include its application in wound healing, treating burns, minimizing frost bite damage, protection against skin damage from x-rays, lung cancer, intestinal problems, increasing high density lipoprotein (HDL), reducing low density lipoprotein (LDL), reducing blood sugar in diabetics, fighting against acquired immuno deficiency syndrome (AIDS), allergies and improving immune system. Phytochemistry of Aloe vera gel has revealed the presence of more than 200 bioactive chemicals. Commercially, aloe can be found in pills, sprays, ointments, lotions, liquids, drinks, jellies, and creams, to name a few of the thousands of products available. In the present scenario, the aloe industry is blooming but the consumers are misguided leading to unfavorable outcome due to reasons like unawareness about its proper and adequate medicinal and health value, improper marketing and unavailability of processing units...
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