Posted by admin on Sep 30, 2025 in |
Ocular monkeypox, a rare but severe consequence of monkeypox virus infection (an Orthopoxvirus), presents with various ophthalmic issues, from conjunctivitis and keratitis to, in severe cases, corneal ulcers and vision loss. Transmission occurs via Close contact with sick people, contaminated objects, or respiratory droplets can spread the infection. Among the symptoms include inflamed eyes, swelling, pain, and discharge, often alongside systemic symptoms like fever, rash, and swollen lymph nodes. Prompt diagnosis and treatment, including supportive care, antiviral medications (e.g., tecovirimat or cidofovir), and management of secondary bacterial infections, are crucial to prevent permanent damage. Corneal transplantation may be considered in vision-threatening cases due to corneal damage. Vaccination, especially with the modified vaccinia Ankara (MVA) vaccine, offers protection and lessens the risk of severe complications, including ocular involvement. Public health strategies, like immunization drives and instruction, are vital for outbreak control and minimizing the impact of ocular and systemic monkeypox. More investigation is required to improve and understand the disease’s mechanisms and improve treatment, prevention, and surgical...
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Posted by admin on Sep 30, 2025 in |
Tremors are a neurodegenerative disorder (ND) characterized by the involuntary movement of body parts such as the soft palate, hands, jaw, tongue, and head. As of February 2020, the Online Mendelian Inheritance in Man (OMIM) database contained over 594 genetic conditions. Tremors can originate due to improper functioning of certain areas of the brain or due to genetic inheritance and is prominently observed in people above 60 years of age and mostly in males. It is present as symptoms in many neurodegenerative disorders like stroke, Parkinson’s, and multiple sclerosis. Many dosage forms have been developed for the treatment of tremors, which include tablets, transdermal patches, sustained release, injectables, and sublingual. The intranasal route of drug delivery is an emerging type of novel delivery system and can be a useful tool for treatment. By following pathways like the trigeminal and olfactory nerve pathways, prominent drug bioavailability in the brain, rapid absorption of drugs, and reduced side effects are achieved. In this review, we have discussed the classification of tremors, the...
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Posted by admin on Sep 30, 2025 in |
Tinospora cordifolia (TC), family Menispermaceae, a widely used herb in Ayurvedic formulations, is known for its therapeutic advantages in the treatment of fever, urinary problems, managing diabetes, metabolic disorders, dysentery, and enhancing immune function. However, its concurrent intake with commonly prescribed drugs raises alarms about potential herb-drug interactions. This review objectives to provide a guide to healthcare professionals (HCP) providing comprehensive knowledge of common pharmacokinetic and pharmacodynamic interactions of TC, focusing on its effects on cytochrome P450 (CYP) enzyme metabolisms, which is critical for the biotransformation of various commonly prescribed drugs. This review also highlighted the mechanism of interaction and clinical implications. By referring to this review, HCP can manage concurrent administration of TC and commonly prescribed medicines, ensuring education to the patient for their safety. Despite the frequent claims that herbal products are natural and safe, it is incorrect to undervalue clinically significant herb-drug interactions or ineffectiveness. Therefore, a careful clinical implication examination has been conducted to assess the effects of TC when used together with commonly prescribed...
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Posted by admin on Aug 31, 2025 in |
Invasomes, within the scope of transdermal medication delivery and cosmetic formulations, nowadays have emerged as impressive technology and are described in comprehensive detail in this review paper. Essentially, invasomes are built from a unique substance, techniques, and processes that can enable active compounds to penetrate easier into the skin than standard liposomes, with the help of phospholipids, ethanol, and terpenes while remaining within the skin boundaries and decreasing systemic absorption. This paper discusses the advantages of invasomes over the conventional delivery systems, including enhanced bioavailability and targeted delivery of therapeutic agents. Other aspects discussed include advancements in nanotechnology and process automation to reduce the production cost and enhance the scalability without any compromise on quality. Review of applications of invasomes in dermo-cosmetic products focuses on their role in treating skin dysfunctions. In summary, it is underscored in this paper that invasomes can revolutionize skincare formulations and hence help overcome multiple dermatological...
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Posted by admin on Aug 31, 2025 in |
It is leukaemia, where immature white blood cells keep growing at a very fast pace and disrupt normal blood production. While there are many advances in treatment, genetics diversity, drug resistant and technological limits remain. Likewise, such AI combined with multi dimension approaches (genetics, transcriptomics, proteomics, metabolism, and epigenetics) has altered leukaemia research. Divining the diagnosis, risk assessment and precise plan for effective treatment from vast amounts of data allowed by AI is possible. In addition, it shortens the time of diagnosis, predicts responses to therapy, and explains how it fails. By integrating AI into mitigation of CML, tyrosine kinase inhibitor is first identified and targeted therapy is guided by other key biomarkers. Same is the case for AML which is mitigated by CK inhibitors and FLT3 inhibitors. Interruption and identification of various pathways by metabolomics and proteomics provide new therapeutic targets. More and more clinical studies show that AI assisted multi-omics strategies add value in making personalized care, reducing relapse, and increasing survival. Since challenges such as data...
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