Posted by admin on Aug 31, 2018 in |
Bioanalysis is a sub-discipline of analytical chemistry covering the quantitative measurement of xenobiotics (drugs and their metabolites and biological molecules in unnatural locations or concentration) and biotics (macromolecules, proteins, DNA, large molecule drugs, metabolites) in biological system. The focus of bioanalysis in the pharmaceutical industry is to provide as quantitative measure of the active drug and/or its metabolite(s) for the purpose of pharmacokinetics, toxicokinetics, bioequivalence and exposure response (pharmacokinetics / pharmacodynamics studies). Over the past several years dried matrix spot (DMS) sampling technique has emerged as a pertinent method in both qualitative and quantitative bioanalysis context. There are many types of DMS techniques such as dried blood spot (DBS), dried plasma spot (DPS), dried urine spot (DUS) and dried breast milk spot (DBMS). The most commonly used technique is DBS wherein the blood sample is directly soaked on to a paper (with or without treatment) and after drying it can be analyzed by modern analytical, immunological or genomic detection systems. Several advantages of DMS techniques such as low sample...
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Posted by admin on Aug 31, 2018 in |
Syzygium cumini (L.) is a widely used medicinal plant for the management of various diseases. Syzygium cumini posses various chemical constituent which are responsible for pharmacological activity. This plant reported to possess many pharmacological activities like anti- diabetic activity, anti-oxidant, anti-inflammatory, anti-diarrhoeal activity, antiviral, antifertility activity, gastroprotective, antipyretic, anti-histaminic, antimicrobial and antiplaque. The present review presents specific information on morphology of plant, cultivation of plant, traditional uses and pharmacological actions of S. cumini (L.). Further applications of Syzygium cumini (Linn.) in the field of novel drug delivery has been also elaborated in the review. Apart from its application in the management of various ailments there is need to explore chemical and toxicity concern of Syzygium cumini...
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Posted by admin on Aug 31, 2018 in |
Cerebral palsy is main general motor disability in the infancy and 2 to 2.5 per 1000 live births affected by the cerebral palsy. The movement restrictions in the cerebral palsy are credited to non-progressive interruption that occurs in developing brain of the infants. It is characterized by means of spasticity, weakness of muscle, primitive reflexes loss, interfering of growth of normal motor control. The motor disorders of the cerebral palsy are frequently accompanied as a result of disturbances of the cognition, sensation, perception, communication and behaviour. The frequent threat factors are, multiple pregnancy, prematurity, small-for-gestational age and infections of the maternal genitourinary. The causal pathways, classification of cerebral palsy and prognostication can play a role in development to prevent the cerebral palsy and arrangement of health services to assemble the desires of the affected infants with disease. This paper covers the causes, clinical features, types, risk factors, pathophysiology and complications of cerebral...
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Posted by admin on Jul 31, 2018 in |
Nipah virus infection (NiV) is a viral infection caused by the Nipah virus. Nipah virus provides one of the most striking examples of an emerging virus and illustrates many of the pathways leading from a wildlife reservoir to human infections. Prior to 1998 there had been no reports of a disease of wildlife, domestic animals or humans that would subsequently be considered infection with Nipah virus. Despite the emergence of the related virus, Hendra, a number of years before Nipah virus, there was nothing to herald the sudden appearance of this virus, which in itself is surprising given the regularity of outbreaks since it appeared. However, the characterization of Hendra virus paved the way for the identification of the causative agent of disease in Malaysian pigs and farm workers and assisted in the recognition of the source of the infection and the pathway from the wildlife reservoir to humans. The symptoms start to appear within 3 – 14 days after exposure. The risk of exposure is high for hospital workers and caretakers...
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Posted by admin on Jul 31, 2018 in |
Now a day’s urogenital cancer is the life threatening disease in worldwide, among them most four life threatening urogenital cancers are kidney cancer, bladder cancer, prostate cancer and testicular cancer. Kidney cancer or renal cell carcinoma (also called adenocarcinoma) is a disease in which malignant cancer cells are found in the living of tubules (renal epithelium). The kidney cancer has the highest mortality rate of the genito urinary cancers and the incidence of kidney cancer has risen steadily. Bladder cancer is a disease in which malignant cancer cells form in the tissues of the bladder. The bladder is a hollow organ in the lower part of the abdomen. Bladder cancer is seventh most basic cancer worldwide and fourth basic growth in men. Prostate cancer is a disease in which cancer cells shape in the tissues of the prostate. Prostate cancer is the fourth most common cancer in the world and more than 1.1 million cases of prostate cancer recorded in 2012. Testicular cancer is a disease when testicular cells...
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