Posted by admin on Jan 31, 2018 in |
The mitochondrion, the “power house of cell”, plays a central role in energy-generating processes so called as ‘‘master of life and death’’. A decline in mitochondrial function plays a key role in the aging process and increases the incidence of age-related disorders. With advanced age, mitochondrial DNA volume, integrity and functionality decrease due to accumulation of mutations and oxidative damage induced by reactive oxygen species (ROS). In aged subjects, mitochondria are characterized by impaired function such as lowered oxidative capacity, reduced oxidative phosphorylation, decreased ATP production, significant increase in ROS generation, and diminished antioxidant defense. Antioxidant defense system, which is responsible for eliminating a wide range of oxidants, especially reactive oxygen species (ROS). As mitochondria are the major site for production of large amount of ROS, mitochondria-targeted antioxidant therapies have shown great effectiveness against the damage caused by enhanced ROS generation, is discussed in this review...
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Posted by admin on Jan 31, 2018 in |
Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules. Coccinia indica belongs to the family Cucurbitaceae. It is a rapidly growing, perennial climber or trailing vine. Traditionally different parts of this plant namely the roots, leaves and fruits are used in folklore medicine for several purposes like jaundice, diabetes, wound healing, ulcers, stomach ache, skin disease, fever, asthma, cough. The leaf and its constituents have been reported to possess anthelmintic activity, antioxidant activity, anti-inflammatory, analgesic and antipyretic activity, antimicrobial activity, antihyper-glycemic activity, hepatoproetcective activity. This review provides adequate information to develop suitable therapeutics out of these plant...
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Posted by admin on Jan 31, 2018 in |
The bio-plastics that are produced either from fossil material or can be synthesized from biomass or renewable resources, such as Poly-lactic acid (PLA), Polyethylene glycol (PEG) and Poly – ε – caprolactone (PCL) are been reported as a material of choice for biomedical applications due to their good physical properties such as crystallinity, storage modulus, glass transition temperature and bioresorbable property. These biodegradable polymers have wide applications in tissue engineering, wound management, drug delivery, orthopedic devices, manufacturing of fibrous and porous scaffolds. Co-polymerizing these biodegradable monomers in varying proportions with other polymer has extended stiffens and physico-chemical properties. Depending on the origin of their materials, bio-plastics are different in their monomer composition and physical property, which make them interesting from medical point of view. This review thus highlights the synthesis and blending of bio-plastics along with their degradation process when used as in biomedical devices. These biodegradable plastics have hydrolysable linkages in the backbones such as esters, orthoester, anhydride, carbonate, amide, urea and urethane that make them biocompatible to...
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Posted by admin on Dec 31, 2017 in |
Pyrimidine is a 5-membered heterocyclic ring which is versatile lead compound for designing potent bioactive agents. This interesting group of compound has diverse biological activities such as antimicrobial, CNS depressant, anti-inflammatory, analgesic, anti-convulsant, anticancer, antihelmentic, antioxidant and herbicidal. Available data represents that pyrimidine being heterocyclic planar five membered ring systems has various pharmacological actions and Synthesis of various pyrimidine derivatives and their pharmacological actions discussed below. These derivatives of pyrimidine are analysed in this article for varying pharmacological activities. This review describes various Pyrimidine derivatives have potent biological and pharmacological...
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Posted by admin on Dec 31, 2017 in |
Lantana camara Linn. is considered as a notorious weed and a popular ornamental plant. It is noted from ancient time that plants have been an excellent source of medicine. Since very long time Lantana camara has been reported as one of the most important medicinal plants in the world. Lantana camara is used in traditional medicine system for the treatment of cuts, swellings, ulcers, cataract, bilious fever, itches, eczema, and rheumatism. Various parts of Lantana camara plant are used in the treatment of cold, headache, whooping cough, asthma, chicken pox, bronchitis, eye injuries, and arterial hypertension. L. camara has scientifically studied for various therapeutic activities like antibacterial, antioxidant, antipyretic, insecticidal, antimicrobial, wound healing, etc. Nowadays this plant Lantana camara is worked in several recent advanced techniques like phyto-extraction of heavy metals, phytoremediation of particulate pollution and many others. Various literature has reported the phytoconstituents present in all parts of Lantana camara. In last few decades, scientist and researchers throughout the globe have elaborately examined the chemical composition of the...
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