Posted by admin on Jun 30, 2018 in |
A diet rich in marine fishes and general seafood has long been recommended by several medical authorities as a long-term nutritional intervention to preserve overall health and wellbeing. An association between consumption of fish and seafood and beneficial effects on a variety of health outcomes has been reported in epidemiologic studies and clinical trials. These effects are mainly attributed to the omega-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) abundant in fish and seafood, and in particular to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Reports on health benefits have led to increased demand for products containing marine n-3 PUFAs. Since fish is a restricted resource, there is growing interest in exploiting alternative sources of marine n-3 PUFAs. Antarctic krill (Euphausia superba) is a rich source of n-3 PUFAs. Most of the health benefits provided by frequent seafood consumption come from adequate uptake of omega-3 and omega-6 polyunsaturated fatty acids, n-3/n-6 PUFAs, and antioxidants. Optimal n-3/n-6 PUFAs ratios allow efficient inflammatory responses that prevent the initiation and progression of many...
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Posted by admin on Jun 30, 2018 in |
The skin covers a total surface area of approximately 1.8 m2 and provides the contact between the human body and its external environment. Transdermal route of drug delivery has gained great interest in pharmaceutical research as it overcomes many problems associated with the oral route of administration. Although the skin, particularly the stratum corneum presents a barrier to most drug absorption, it provides a large (1.2 m2) and accessible surface area for drug diffusion. Recently, various strategies have been used to augment the transdermal delivery of bioactives. Mainly, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, magnetophoresis, microneedles, vesicular systems (liposomes, niosomes, elastic liposomes such as ethosomes, transfersomes and transethosomes). Among these transethosomes appear to be more promising as they possess both lipophilic and hydrophilic regions and can accommodate drug molecules with a wide range of solubility. Transethosomes can deform and pass through a narrow constriction that is 5 to 10 times less than its own diameter. This high deformability gives better penetration of intact vesicles. These vesicles can...
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Posted by admin on Jun 30, 2018 in |
Arsenic (As) is a metalloid. It occurs in almost every fraction of the environment. It is moving in each and every corner of our environment. Levels of arsenic (As) in the environment have become a global concern due to its toxicity and adverse effects on human health and other living beings. It is highly toxic even at low concentrations. It is also carcinogenic. Although, its natural sources are igneous and sedimentary rocks, the anthropogenic source of arsenic (As) plays an important role to maintain its concentration in our environment. The mining, smelting and refining, industrial processes, coal combustion, and waste incineration are released arsenic (As) in the environment. It may undergo cycling processes in the environment after release in the environment. This cycling process occurs depending upon few factors such as its oxidation state, speciation, concentrations and the presence of organic matter, competing ions, and other environmental factors (e.g., pH, redox). This paper reviews the natural and anthropogenic occurrence of arsenic in the environment, toxicity of arsenic and newly invented scientific low coast household and the other...
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Posted by admin on Jun 30, 2018 in |
The use of scorpion venom has a very old history in traditional medicine for thousands years ago in China, India and Africa worldwide. The inhibition of cancer progression and induce apoptosis have shown in an increasing number in-vitro and in-vivo studies. We accomplished this systematic review to evaluate the performance of scorpion venom and its components in the growth inhibition of cancer cell lines. To provide a full data for future researches, the in-vitro and in-vivo studies were adopted in this research. The literature search for the published articles from January 1st, 1968 to January 1th, 2018 was done in PubMed, ISI Web of Science, Scopus, and Science Direct. All the articles were independently screened by applying some predefined criteria by two reviewers in three consecutive steps. We identified 53 eligible studies from among 1,209 studies. So far, scorpion venom and its components have been discovered to inhibit the growth of 38 various types of cancer cell lines. This was the first systematic review includes some tables that provided...
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Posted by admin on Jun 30, 2018 in |
Chitin is the second most important natural amino polysaccharide polymer after cellulose in the world. The main sources exploited are marine crustaceans, shrimp, and crab apart from that some other lobstera, insects, sulphur butter and fungi. Chitosan is the most important natural based common cationic polymer got from chitin has gotten developing consideration for the most part due to their bio-degradable, bio-compatible, bio-renewable and non-lethal properties. The deacetylated chitin derivative chitosan is a useful and interesting bioactive polymer; it has a large pharmaceutical application either. It has numerous reactive amino side groups, which offer possibilities of chemical modifications, formation of a large variety of beneficial derivatives. Chitosan has been found to be used as a support material for pharmaceutical application, gene delivery, cell culture, and tissue engineering. This review is based on the various pharmacological activity of chitosan such as wound healing, anti-hypertensive, anti-cancer, blood coagulant, anti-coagulant, anti-ulcer, anti-microbial, anti-viral, hypolipidemic and hypocholesterolemic...
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