Posted by admin on Jun 30, 2018 in |
Neurodegenerative disorders particularly Parkinson’s disease are serious threat for heath society. In addition, treatment, control and managing of Parkinson’s disease burden high cost to these patients. Therefore, an efficacy and available treatment strategy is required so that herbs and their bioactive compounds could be good candidates. It has well been demonstrated the herbs are a potential source of antioxidant and have anti-inflammatory property. Interestingly, oxidative stress and inflammation are main reasons neurodegeneration in substantia nigra pars compacta. Here, we review the studies conducted on effects of extracts and compounds obtained from herbs in treatment of Parkinson’s disease until 2000 to now by to focus on their effects on different animal model of Parkinson’s...
Read More
Posted by admin on Jun 30, 2018 in |
The first case of middle east respiratory syndrome (MERS) was identified in a mid-aged Saudi Arabian resident in 2012. The syndrome is analogous to severe acute respiratory syndrome (SARS) in its clinical course, with a male predominance in incidence. MERS virus is disseminated as a result of close proximity of people to camels, person to person transmission being uncommon and confined to hospital settings. The incubation period usually lasts for 2 – 14 days. MERS-CoV appears to be an enzootic virus, tracing its origin to bats, whereas camels may act as intermediate hosts. Typical flu-like symptoms are observed, which include pyrexia, myalgia, apnoea and cough. Symptoms advance over time leading to multiple organ failure, septic shock and eventually death. Diagnosis can be done with the aid of recombinant IgA and IgG ELISAs, and other specific assays such as upE and real-time Reverse Transcription (rt-RT) PCR assay. Currently, neither an authorized vaccine nor a definitive treatment is available for human use. However, adenosine deaminase, mycophenolic acid (MPA), cyclosporine A, nelfinavir,...
Read More
Posted by admin on May 31, 2018 in |
Vesicular systems have gained immense importance in the last few years as a means for sustained and efficient drug delivery. This article was designed to review all aspects of a novel class of vesicles, transfersomes. Tranfersomes and the fundamental concept of transfersomes were launched by Gregor Cevc in the year 1991. It exists as an ultra-deformable complex having a hydrated core surrounded by a complex layer of lipid. The carrier aggregate is composed of at least one amphipathic molecule (like phospholipids) which when added to aqueous systems self-assemble into a bilayer of lipid which eventually closes into a lipid vesicle and one bilayer softening agent which is generally a surfactant which is responsible for the flexibility of the vesicle. Transfersomes provide the primary advantage of higher entrapment efficiency along with a depot formation which releases the contents slowly. The characterisation of transfersomes is similar to that of other vesicles like liposomes, niosomes and micelles. Transfersomes can be used for delivery of insulin, corticosteroids, proteins and peptides, interferons, anti-cancer drugs,...
Read More
Posted by admin on May 31, 2018 in |
Low temperatures have been reported to be having far reaching effects on all plant species. The effects, in turn depend on the low temperature sensitivity of each and every plant species. In nature, the effects of various stresses may be seen overlapping thus the effects may be specific or non-specific. The effects in response to low temperature can be well ameliorated by the exogenous application of various protective molecules viz., proline, glycine betaine, trehalose. Various cold tolerant transgenic crops over-expressing these molecules have also been...
Read More
Posted by admin on May 31, 2018 in |
It has been reported that mortality associated with diabetes is about 2.9 million cases in World. The most common diabetes complications consist of cardiovascular disease, renal failure and blindness. The increase of lipid oxidation and reduction of antioxidants in mitochondrial dysfunction were showed. The role of investigation on mitochondria damage is requiring for evaluation of insulin resistance. In this study, we reviewed the relationship between mitochondrial function to diabetes and its complications according to latest study during 2011 – 2015 using databases such as pubmed, science direct and web of...
Read More
