Posted by admin on Mar 31, 2018 in |
Cancer is a major public health burden in both developed and developing countries. It is actually a group of many related diseases that all have to do with cells. It is one of the major causes of death worldwide where the number of cancer patients is in continuous rise. It is a major public problem whose estimated worldwide new incidence is about 6 million cases per year. It is the second major cause of deaths after cardiovascular diseases. There is a constant demand for new therapies to treat and prevent this life-threatening disease. The plant kingdom produces naturally occurring secondary metabolites which are being investigated for their anticancer activities leading to the development of new clinical drugs. Worldwide effects are ongoing to identify new anticancer compounds from plants. In recent years owing to the fear of side effects people prefer more and more use of natural plant products for cancer. For these reasons, World Health Organization (WHO) supports the use of traditional medicines which are efficacious and non toxic....
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Posted by admin on Mar 31, 2018 in |
The process of drug development and drug discovery is very challenging, expensive and time consuming. It has been accelerated due to development of computational tools and methods. Over the last few years, computer aided drug design (CADD) also known as in silico screening has become a powerful technique because of its utility in various phases of drug discovery and development through various advanced features. In silico screening also paves path for the synthesis and screening of selected compounds for better therapeutics. This review focuses on computational chemistry and computer aided drug discovery which are aimed to cover a wide range of computational approaches including new methodologies as well as practical aspects in this area. This review provides an insight about the developmental chain, approaches and applications of CADD; various data sources; computational methods for the discovery of new molecular entities; clinically approved drugs developed through CADD; and also summarizes the crucial steps of in silico drug designing like homology modelling, docking, multi-target searching and design, pharmacophore development, conformation generation...
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Posted by admin on Feb 28, 2018 in |
Lycopene, a non-provitamin a carotenoid, found in tomatoes, processed tomato products and other fruits, due to which red to pink coloration is observed. Among all the dietary carotenoids, lycopene is one of the most potent naturally and abundantly occurring antioxidant. Lycopene has unique structural features and chemical features which contribute to specific biological properties and pharmacological activities. The antioxidant potential of lycopene may be responsible for its associated health benefits. Dietary consumption of tomatoes and tomato products rich in lycopene are reported to be associated with a decreased risk of chronic diseases, like cancer and various cardiovascular diseases. Further investigations will be required to understand and evaluate mechanism whereby lycopene and its metabolites are proven to possess biological activities in human. This review summarizes the current understanding of lycopene with respect to its role in human health and prevention of various...
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Posted by admin on Feb 28, 2018 in |
Solid lipid nanoparticle is the forfront of the rapidly developing field of nanotechnology and as an alternative to other traditional colloidal carriers like liposomes, polymeric nanoparticles and emulsions as they have advantages like controlled drug release and targeted drug delivery with increased stability. Objective: Solid lipid nanoparticles (SLNs) consist of spherical solid lipid particles in the nanometer size range, which are dispersed in water or in an aqueous surfactant solution. SLN technology represents a promising new approach to deliver hydrophilic as well as lipophilic drugs. Due to their unique size dependant properly, lipid nanoparticles offer to devlop the new therapeutics. Method: The incorporation of drugs into nanocarriers offers a new prototype in drug delivery that could be used for several levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site-specific drug delivery and hence have attracted the wide attention of researchers. Conclusion: The present review article focus on overview about the potential advantages, disadvantages, the excipients and all the different...
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Posted by admin on Feb 28, 2018 in |
Glipizide is second generation Short acting sulfonylurea prescribed for treatment of type II diabetes Mellitus. It is with short biological half-life of 3.4 ± 0.7 hrs and metabolized in the liver and excreted in the urine largely as inactive metabolites. The clinical and pharmaceutical analysis of drug requires analytical procedures along with pharmacokinetic and pharmacodynamic data with stability study for any analysis of drug. In the present review we have compiled different published analytical methods for determination of glipizide in pharmaceutical methods. The table no 1 indicate Analytical method development and validation of single Glipizide drug by HPLC method; while table no 2 indicates Analytical method development and validation of glipizide with combination of other drugs by HPLC method. In the literature review table no 3 and 4 indicates Analytical method development and validation of glipizide as well as other drugs in combined forms by UV spectrophotometer. This literature review also involved tabulated information about various formulations available of glipizide along with their method of formulation and polymers used...
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