Posted by admin on Aug 31, 2017 in |
Quality by Design [QbD] is a science based approach widely used in industry to continually monitor and improve the quality of product. It is a modern risk based strategic framework of all the aspects related to quality. ICH guidelines Q8 to Q11 summarizes all the different perspectives of quality by design system in required depth along with ways to implement it. This review in all focuses on the general terms of QbD its meanings and application along with different wide range applications of the QbD to pharmaceutical fields like Analysis, Formulation, Design and Technology development, Control Strategies etc. Also it includes a short view over the application of Various QbD tools like PAT, CAPA and HACCP in Pharmaceutical industry along with their importance in the Quality aspect of Pharmaceutical products. It also tries to cover the major aspects to be concerned while selecting the wide ranges of designs and statistical tools while employing QbD to a Particular aspect of Pharmaceutical...
Read More
Posted by admin on Aug 31, 2017 in |
In recent years more people throughout world are turning to use medicinal plant products in healthcare system. Worldwide need of alternative medicine has resulted in growth of natural product markets and interest in traditional systems of medicine. Proper integration of modern scientific techniques and traditional knowledge is important. There is a growing focus on the importance of medicinal plants in the traditional health care system (viz. Ayurveda, Unani, Homoeopathy, Yoga) in solving health care problems. Systematic approach and well-designed methodologies for the standardization of herbal raw materials and herbal formulations are developed. The stability testing of herbal products check the quality of herbal products which varies with the time under the influence of environmental factors, such as temperature, humidity, light, oxygen, moisture, other ingredient or excipient in the dosage form, particle size of drug, microbial contamination, trace metal contamination, leaching from the container, etc. and also provide statistics for the determination of shelf lives. Therefore evaluation of the parameters based upon chemical, physical, microbiological, therapeutic and toxicological studies can...
Read More
Posted by admin on Aug 31, 2017 in |
Retinoids are the derivatives of Vitamin A and have similar action to that of Vitamin A. Sources of Vitamin A such as eggs and meat are known to contain a chemical, retin-A which is known to be useful for treating various dermatological disorders. Tretinoin, a first generation retinoid was first used orally for the treatment of acne in 1940s. Topical tretinoin was later developed as a result of potential adverse effects when given orally and it showed promising therapeutic effect for keratinizing disorders such as actinic keratosis and ichthyosis. Other systemic retinoids such as isotretinoin, acitretin and bexarotene were also studied consecutively which gained approval from US-Food and Drug Administration for a number of keratinisation disorders like acne vulgaris, psoriasis and mycosis fungoides respectively. Along with these disorders, systemic retinoid are widely used for various off label dermatological conditions but due their potentially serious adverse effects, their use has been contraindicated in a number of conditions, especially for pregnant women where it is reported to cause serious embryo-foetal abnormalities....
Read More
Posted by admin on Aug 31, 2017 in |
Norfloxacin is one of the 4-quinolone antibacterials and have many applications in veterinary and human medicine. It is extensively used antibiotic among fluoroquinolone antibiotics in both human and animal welfare. Therefore, the estimation and monitoring of norfloxacin in pharmaceutical preparations and effluents has become a topic of interest for researchers and industries. Existing methods require much time, expenses and sophisticated laboratory facilities. Most of the methods suggest the simultaneous determination of the drug along with the similar groups. There is a thirst among researchers for the development of simple, specific, sensitive and reliable methods suitable for routine laboratory facilities. Most of the methods are based on association of the drug either with metal complexes or reaction with pigments. The main objective of this paper is to review various existing methods for spectrophotometric determination of norfloxacin in order to explore the possibilities to overcome their drawbacks to develop new methods with enhanced simplicity, sensitivity, reproducibility,...
Read More
Posted by admin on Jul 31, 2017 in |
Eessential oils are known to possess antimicrobial activity. This review article explains the antimicrobial reaction, application, effects, and characteristics of cinnamaldehyde. Amongst the different essential oils, Cinnamaldehyde is observed to be the most effective antimicrobial agent. The current studies on cinnamaldehyde in the field of microbiology have been highlighted. This review explains the different methods, those are used for antimicrobial evaluation. Additionally, the anti-physiologic effect of antimicrobial agents using microbial respiration rate is also...
Read More
