Posted by admin on Jul 31, 2017 in |
Targeted drug delivery, known as smart drug delivery focuses on targeting the medicaments by increasing the residence time and the concentration of drug at the target site of the body (organs, cells, tissues) thus improving the efficacy of treatment and reducing the side effects. Various carriers that can be used in this type of delivery are liposomes, nanoshells, erythrosomes and resealed erythrocytes. In this Innovation era, resealed erythrocytes have become the choice of drug delivery system because of its excellent biocompatibility, biodegradability and ability to entrap several molecules. The promising aspect of resealed erythrocytes makes them useful as a drug carrier. They have reduced toxicity, improved pharmacokinetic properties that help in transport of active ingredient to the targeted site. This property makes them superior as compared to the conventional drug delivery system. The method of isolation involves collection of sample from the interest, then separating the plasma and finally resealing it. Erythrocytes are prepared by using methods like hypotonic dilution, hypotonic dialysis, pre-swelling, osmotic lysis, endocytosis and chemical penetration....
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Posted by admin on Jul 31, 2017 in |
Seaweeds are not a common weed, its valued marine plants. In Indian coast around around 800 seaweed species belonging to Chlorophyta, Phaeophyta and Rhodhophyta. Seaweeds constitute one of the commercially important renewable marine living resources. Seaweeds have various commercially valuable products such as pharmaceutical and cosmaceutical compounds, plant growth pro-moters, Nitrogen fixers, bio-energy and functional foods. The seaweeds are very rich in nutrition level, because of their low content in lipids, high concentration in polysaccharides, minerals, poly-unsaturated fatty acids and Vitamins as well as their content in bioactive molecules, marine algae are known to be a good source of healthy food. The need for marine natural products like Carrageenan, Kainoids, Polycavernoside A, chondriamides A, B and C have grown enormously in the last fifty years. Especially marine macro algae are wonderful salubrious sources of biologically active natural products. This review highlights the current knowledge of seaweed biotech-nology in the...
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Posted by admin on Jul 31, 2017 in |
Heparin-induced thrombocytopenia (HIT), a devastating immune mediated adverse drug reaction, is triggered by the development of antibodies that stimulates the platelet activation in presence of heparin. Bleeding is infrequent in HIT patients regardless of thrombocytopenia; however, HIT is strongly associated with thromboembolic complications involving both venous and arterial systems. Numerous novel oral anticoagulants exist that may be beneficial for HIT, principally in cases refractory to standard therapies. However, these agents have not been fully evaluated for treatment of patients with HIT and hence none have FDA approval for use in HIT. Diagnosis of HIT is a bit challenging because of the routine use of heparin in hospitalized patients, which is one of the common consequences of thrombocytopenia. Numerous laboratory tests are available to confirm the diagnosis of HIT, but its clinical suspension remains crucial to the early cessation of heparin and initiation of alternative therapy. Treatment includes the initiation of alternative anticoagulants resulting in the reduced prevalence of...
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Posted by admin on Jul 31, 2017 in |
The tradition of home treatment is found in all cultures throughout the world whether in developed or developing countries. Few herbal drugs commonly appear in the home use as a medicine. One such drug is Zanjabeel, it is the rhizome of Zingiber officinale Rosc. It is a popular culinary spice that was used as an important medicine by ancient Unani physicians. It is a very important drug of house hold medicine kit used mainly as antiflatulant, digestive, anti cough and other indications mentioned in traditional Unani text. Beside its traditional uses its new indications are as an, ant-emetic, hypocholesterolaemic antioxidant, antimicrobial, cardioprotective etc. Unani medicine has provided lot of information regarding this drug. Fresh look on the indications of Zanjabeel is needed in the light of current research performed on it and further scope of research can also be explored with the help of traditional knowledge exist in Unani medicine. This review is an attempt in this direction, so that Zanjabeel can become more beneficial to ailing people and...
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Posted by admin on Jul 31, 2017 in |
Now a day the recent development in new drug delivery systems plays a vital role in pharmaceutical industries. The drug delivery practice has been modified in the last decades and even many advanced innovations happened in recent times. Newer drug delivery systems are largely influencing the current medical practice. Alterations of a traditional or conventional drug delivery into a new drug delivery system can absolutely changing the bioavailability, safety and efficacy of the drug and also it can produce improved patient compliance. Now a day, the scope of controlled drug delivery system is tremendously influencing the pharmaceutical dosage forms because it offers a wide range of products. Out of all controlled release products, Microspheres is one among all because of the controlled release and sustained release properties. This paper focus on the various types of microspheres along with their method of preparation and basic technique to evaluate its efficiency with most important emphasizes on pharmaceutical application of microspheres by means of microspheres taken by various routes of system such...
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