Posted by admin on Dec 31, 2017 in |
Cardiotoxicity associated with the clinically used drugs is a global concern of safety for healthcare professionals. Various animal models have been used to study the drug-induced cardiotoxicity but the exact molecular involvement of toxicity is not much clear. Despite the recurrent occurrence of toxicities, drugs such as doxorubicin, calcium channel blockers, antiarrhythmics and immunomodulators are regularly used. Anticancer drugs mainly anthracyclines, 5- fluorouracil and cyclophosphamide exert prominent cardio-toxicity. Till date, there is only one drug approved for doxorubicin-related cardiotoxicity i.e. dexrazoxane. Few other drugs are used routinely by clinicians to reduce the severity of toxicity which includes ACE inhibitors, L-carnitine, probucol, CoQ10, N-acetylcysteine, Vitamin E and deferoxamine, whereas antidepressants drugs, specifically tricyclic antidepressants are potential candidates for cardiotoxicity. Calcium channel blockers, antiarrhythmic and beta receptor antagonist aggravate cardiac heart failure (CHF) and left ventricular arrhythmia. Interferons, mainly interferon-α is also associated with prominent and dose-dependant toxicity. Some other drugs like zidovudine, chloroquine, cocaine, minoxidil, ketoconazole, prostaglandin E2 and anagrelide are also reported to have cardiotoxic effects. A complication associated...
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Posted by admin on Dec 31, 2017 in |
Biophytum sensitivum DC. (Family – Oxalidaceae), commonly known as “Lajjalu” in Northern India, is an annual herb that grows at the foothills of the Himalayas. It is an indigenous medicine, used against “Madhumeha” (Diabetes mellitus) apart from being used as tonic, stimulant, and in the treatment of stomach ache, asthma, insomnia, convulsions, cramps, chest-complaints, inflammations, tumours and chronic skin diseases. It has been scientifically screened for various pharmacological activities such as anti-tumour, antipyretic, immunomodulatory, antidiabetic, antiulcer, radio-protective, larvicidal, antibacterial and antioxidant. Phytochemical investigations showed the presence of flavonoids and phenolic compounds as the major constituents. The present work attempts to compile a review on macroscopic characteristics, chemical constituents, pharmacological reports, clinical studies, formulations and patents listed for this plant. The data has been collected from major databases like Chemical Abstracts, Medicinal and Aromatic Plants Abstracts, PubMed, Scirus, Science Direct, and other online and electronic databases’ which has then been systematically collated for a holistic review about Biophytum...
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Posted by admin on Dec 31, 2017 in |
Endometrial thickness is one of the determinant factors in fertility success. This study was carried out to determine the effects of plants on increasing endometrial thickness and ultimately increasing fertility preservation. Key terms of “endometrium thickness” or “endometrial thickness” or “endometrial lining thickness” in combination with the words “Medicinal plant”, “Herb” and “Phyto” were searched on the ISI, PubMed and Scopus databases. Then, the abstracts of the articles, as well as information obtained from other sources about medicinal plants and their derivatives from which their effects directly on endometrial thickness and pregnancy were studied, were selected. Besides, only clinical trials and laboratory studies between 2007 and 2017 were included. The results from this study showed that plants such as Cimicifuga racemosa and Aspalathus lineararis and plant derivatives such as Klimadynon and Icariin and plant formulations such as Xiaoyao powder, Erzhi pill and Siwu decoction can increase fertility in humans or animals by increasing endometrial thickness. Medicinal plants and their derivatives affect the thickness of the endometrium, mainly due to...
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Posted by admin on Nov 30, 2017 in |
Antimicrobial resistance has been called one of the world’s most pressing public health problems. Addressing the issue of antimicrobial resistance is one of the most urgent priorities in the fields of public health today. Alarmingly, the development of resistance such as multi-drug resistance towards a number of antibiotics poses a challenge to the scientific community in the discovery of new therapies. Thus, there is a need to develop newer and effective molecules with high safety profile. Benzothiazoles are fused membered rings, which contain heterocycles bearing thiazole. Sulphur and nitrogen atoms constitute the core structure of thiazole and many pharmacologically and biologically active compounds. Benzothiazole is an interesting pharmacophore exhibiting diverse pharmacological activities like antimicrobial, anticancer, anthelminthic, antidiabetic, antitubercular, anticonvulsant, antioxidant, anti-inflammatory, antifungal, antipsychotic etc. The present article extensively covers various procedures of synthesis of 2-substituted benzothiazole core and its analogs – by utilizing distinctive catalysts, solvent conditions, reactants immobilized on solid support and microwave irradiation. Variations in synthetic procedures are studied to explore chemo-selectivity of the reactions, in-expensive, eco-friendly,...
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Posted by admin on Nov 30, 2017 in |
A variety of Nano-biomaterials are synthesised, characterised and tested to find out their potentialities by global scientific communities, during the last three decades. Among those, nanostructured ceramics, cements and coatings are being considered for major use in orthopaedic, dental and other medical applications. The development of novel biocompatible ceramic materials with improved biomedical functions is at the forefront of health-related applications, all over the world. Understanding of the potential biomedical applications of ceramic nanomaterials will provide a major insight into the future developments. This study reviews and enlists the prominent potential biomedical applications of ceramic nanomaterials, like Calcium Phosphate (CaP), Tri-Calcium Phosphate (TCP), Hydroxy-Apatite(HAP), TCP+HAP, Si substituted HAP, Calcium Sulphate and Carbonate, Bioactive Glasses, Bioactive Glass Ceramics, Titania-Based Ceramics, Zirconia Ceramics, Alumina Ceramcis and Ceramic Polymer...
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