Posted by admin on Nov 30, 2017 in |
Peptide drugs are poorly absorbable and are also susceptible to enzymatic degradation in the gastrointestinal tract (GIT). To overcome the physiological and morphological barriers for the peptide / poorly absorbable drug delivery, mucopenetrative and mucoadhesive properties of drug carriers have to be considered. Mucoadhesion can prolong the residence time of drug carriers at the absorption sites, improved drug absorption and controlled release of drug from the device used. The particles with smaller size were likely to diffuse much faster into the mucus layer, provided that diffusion of the particles into the mucus layer should obey Stokes-Einstein equation. The adhesiveness of the nanoparticles (NPs) in suspension form helps to improve bioavailability. Chitosan (CS) based or CS-coated NPs represent another common group of mucoadhesive systems. Moreover, NPs made of such polymers were used to enhance the bioavailability, and also the mucoadhesion of proteins, peptides and DNA to the mucosal tissues. This review focuses on the mechanism of gastrointestinal mucoadhesion of NPs for peptide/poorly absorbable...
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Posted by admin on Nov 30, 2017 in |
India is a focus for development of Ayurveda, Unani, Siddha, Homoeopathy and another natural herbs based health science (AYUSH). Ayush Pharmaceutical industry having great possible and contingency for saundarya prasadka category (herbal cosmetic) development in future. Natural beauty is blessing and cosmetics help in presenting and increaning the beauty and personality aspects of human beings. Saundarya prasadak are the preparation, which represent cosmetic base correlate with known Ayurveda, Siddha and Unani (ASU) drugs active ingredient (which reference are readily available in schedule 1st book of Drug and cosmetic act 1940 and rule 1945). In traditional era people were used to various lepa, Alepa, Pralepa, Udavartan, Prakshalan etc for saundrya prasadan karma. Nature has offered the way to keep up that parity. Herbs! Yes herbs are one such means. An herb is a plant or plant extract, including leaves, bark, berries, roots, gums, seeds, stems and flowers which are favour with nourishing and healing elements. Cosmetics alone are not competent to take care of skin and others body parts, it...
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Posted by admin on Nov 30, 2017 in |
The aim of this review is to assess the efficacy of treatments for postmenopausal osteoporosis in women with low bone mass or with an existing vertebral fracture. Osteoporosis is a worldwide health problem related to the aging of the population, and it is often under diagnosed and undertreated. It is related to substantial morbidity, mortality and impairment of the quality of life. Estrogen deficiency is the major contributing factor to bone loss after menopause. Postmenopausal osteoporosis is a silent disease in most cases, with no symptoms until fractures occur. It is characterized by low bone mineral density (BMD) and changes in bone micro architecture that reduce bone strength and increase fracture risk. The objective of this study was to present a systematic review of drugs for treatment of osteoporosis, focusing on the adequacy of clinical protocols based on existing evidence in the scientific literature. So, our study recommends that postmenopausal women should be screened for osteoporotic fracture risk which may be important strategy in the management of postmenopausal...
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Posted by admin on Nov 30, 2017 in |
Allergic Rhinitis (AR) represents a common and serious health problem in pediatric age group in term of outpatient visit. The chronic nature of disease and its association with other comorbid conditions like asthma, eczema etc. has shown significant negative impact on quality of life, school performance and cognitive functioning in children which has influenced many parents to seek alternative therapies. Moreover there is a growing concern of long term use of dose related side effects of corticosteroids, antihistaminic etc. Considering etiopatho genesis of AR, Ayurvedic herbal drugs possessing properties of antihistaminic, mast cell stabilizer and immunomodulators, alone or in combination can show positive effects in relieving the symptoms of AR. Thus in this review paper, an attempt has been made in this direction to prepare a comprehensive list of herbal drugs with above aforementioned properties that can help in the management of AR in pediatric age group with better clinical efficacy and safety...
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Posted by admin on Nov 30, 2017 in |
It is well known that some plants have medicinal properties and their knowledge has been accumulated in the course of many centuries, based on different medicinal systems such as Ayurveda, Unani and Siddha. In India, it is reported that traditional healers use nearly 2,500 plant species and 100 plant species serve as regular sources of medicine for the treatment of various diseases. Alzheimer’s disease is globally recognized as the most common form of dementia and it disrupts critical metabolic processes which keep neurons healthy. These disruptions cause nerve cells in the brain to stop working, lose connections with other nerve cells and finally die. The destruction and death of nerve cell causes the memory failure, personality changes and problems in carrying out daily activities. The Alzheimer’s disease has an abundance of two abnormal structures- amyloid plaques and neurofibrillary tangle. The Alzheimer’s disease is caused by a mixture of genetic, environmental, and life style factors. The current review methodically summarizes the Alzheimer’s disease and the effects of phyto-chemicals of medicinal...
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