Posted by admin on May 31, 2017 in |
Tuberculosis (TB) remains one of the main causes of death from an infectious disease till date. Recent data shows that currently 9.6 million people are infected with TB. Over 95% of TB deaths occur in low- and middle-income countries and it is among the top 5 causes of death for women aged 15 to 44. TB is a leading killer of HIV-positive people and around 1 in 3HIV deaths was due to TB. Furthermore, multidrug-resistant (MDR)-TB and extensively drug-resistant (XDR)-TB is spreading and poses a major threat to progress in global TB control program. The emergence of drug resistant TB strains makes the invention of new molecular scaffold a priority. One of the possible strategies to overcome drug resistance in an economic and simple manner would involve re-engineering and repositioning of some old drugs to obtain derivatives that can work on resistant TB bacilli. These may have enhanced bioavailability, be more effective, and serve as cost-effective substitutes, as compared to new drugs identified through conventional methods of drug discovery and development....
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Posted by admin on May 31, 2017 in |
Liposomes have been established as a promising novel drug delivery vehicle in several different basic sciences. Liposomes are microscopic spheres with an aqueous core surrounded by one or more outer shells consisting of lipids arranged in a bilayer configuration. Liposomes are acceptable superior carriers having ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradation. It also has affinity to keratin of horny layer of skin and can penetrate deeper into skin and hence give better absorption. Liposomes may act as a solublizing matrix for poorly soluble drugs and penetration enhancer when applied on the skin as well as local depot at the same time diminishing the side effects of these drugs. Topical liposome formulations could be more effective and less toxic than conventional formulations. The liposome gel formulations could perform therapeutically better effects than the conventional formulations, as prolonged and controlled release topical dosage forms, may lead to improved efficiency and better patient...
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Posted by admin on May 31, 2017 in |
Medicinal plants used in traditional medicine and various cultures can be valuable resources for discovering new drugs. This review was conducted to report Iranian medicinal plants effective on sexual dysfunction (sexual desire disorders, erectile dysfunction, and premature ejaculation). To conduct this systematic review, the search terms Sexual*, Aphrodisiacs, Erectile, and Libido* combined with Medicinal plants, Herb*, and Phyto* were used to retrieve relevant publications from the databases International Scientific Institute, PubMed, Scopus, and EBSCO. Tribulus terrestris, Rosa damascena, Crocus sativus L., rosmarinic acid, and crocin are a number of medicinal plants and their derivatives that have libido-boosting properties. C. sativus, Zingiber officinale, and Peganum harmala are some of the plants that exert therapeutic effects on erectile dysfunction. Boswellia serrata and Lavandula angustifolia are two plants used to treat premature ejaculation. Medicinal plants that are used to treat sexual dysfunctions in Iran can help to improve sexual desire disorders, erectile dysfunction, and premature ejaculation through certain mechanisms such as affecting the cerebral neurotransmitters and sex cells, increasing physical strength, causing...
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Posted by admin on May 31, 2017 in |
Syzygium cumini (L.) is a widely used medicinal plant for the treatment of various ailments. The plant contains anthocyanins, glucoside, ellagic acid, isoquercetin, kaempferol, and myricetin as its chief active constituents. These active cons isoquercetin, kaempferol tituents impart multiple pharmacological activities to the plant which includes antidiabetic, anticancer, antioxidant, antibacterial, antifungal and antidiarrhoeal activity. The present review presents specific information on botany, phytochemical constituents, traditional uses and pharmacological actions of S. cumini (L.). Further applications of Syzygium cumini (L.) in the field of novel drug delivery has been also elaborated in the review. Apart from its application in the treatment of various diseases there is need to explore chemical and toxicity concern of S. cumini...
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Posted by admin on May 31, 2017 in |
Cinnamaldehyde is derived from the cinnamon essential oil (EO) having many biological and pharmacological significance. This review article explains the source, chemistry, physico-chemical characteristics of the molecule. The synthesis of its different analogous has been duly highlighted. The different applications narrating the various usage have been reported. It is expected that this review shall serve as a base material for future research in various...
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