Posted by admin on Aug 31, 2017 in |
Global market of generic drug has been propelled by new government initiatives to produce generic drugs and to promote the use of generic drugs; thus the use of generic pharmaceutical products represents over half of the total volume of pharmaceutical products used worldwide. India is the world’s largest exporter of cost effective generic medicines and leading Indian generic companies are generating more than fifty percent revenue from the export business of generic drugs. After the expiry of patent or marketing rights of the patented drug, generic drugs can be marketed. Generic drugs are available at affordable prices with assured quality and therapeutic value. The decision on drug approval is taken only after being assured of its pharmaceutically equivalent and bioequivalent properties. According to an estimate from the World Health Organization (WHO), the percentage of population without adequate access to essential medicines is less than 1% in high-income countries, 24% in middle-income countries, and 39% in low-income countries, due to their high cost. Recently Govt. of India has launched a...
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Posted by admin on Aug 31, 2017 in |
Coleus forskohlii is an herb historically used in Ayurvedic medicine. Nowadays Coleus forskohlii is used as a fat burning supplement in various formulations and available in the Indian market. Forskolin the main constituent of this plant is used to treat allergies, skin conditions such as eczema and psoriasis, painful menstrual periods, irritable bowel syndrome (IBS), urinary tract infection (UTI), bladder infections, advanced cancer, blood clots, sexual problem in men, insomnia, and convulsions. Healthcare providers sometimes give forskolin intravenously (by IV) for heart failure. Some people breathe in (inhale) forskolin powder for asthma. Forskolin drops are used in the eyes to treat glaucoma. Because of its wide use, this plant some time been adulterated with its species and other varieties. The standardisation parameters are important for this plant in every herbal formulation. With the developments in modern instrumental methods it is high time for the herbal drug manufacturers to come out with the standard level of this drug to be included in the formulation. An extensive study of phytochemical constituents...
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Posted by admin on Aug 31, 2017 in |
It is well known ionizing radiations produce deleterious effects on humans. In spite of research efforts for the past several years, today we do not have a radio protective agent that meets all the prerequisites like produces no cumulative and irreversible toxicity, offers effective long term protection, possess a shelf life of 2-5 years and can be easily administered. In recent years, attention has been turned to phytochemicals due to their antioxidant properties. This review focuses on the radio protective potential of resveratrol [trans-3, 5, 4’- trihydroxystilbene], a phytoconstituent, mainly found in Vitis vinifera. In particular, it aims to highlight the detailed studies, both in vitro and in vivo, that have been carried out on the radio protective capability of resveratrol. It also focuses on the different possible mechanisms through which resveratrol acts in response to ionizing radiations. Previous studies show both positive and negative aspects of resveratrol on radioprotection. But a thorough analysis including earlier studies and our own preliminary studies clearly support that resveratrol is an attractive...
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Posted by admin on Aug 31, 2017 in |
Quality by Design [QbD] is a science based approach widely used in industry to continually monitor and improve the quality of product. It is a modern risk based strategic framework of all the aspects related to quality. ICH guidelines Q8 to Q11 summarizes all the different perspectives of quality by design system in required depth along with ways to implement it. This review in all focuses on the general terms of QbD its meanings and application along with different wide range applications of the QbD to pharmaceutical fields like Analysis, Formulation, Design and Technology development, Control Strategies etc. Also it includes a short view over the application of Various QbD tools like PAT, CAPA and HACCP in Pharmaceutical industry along with their importance in the Quality aspect of Pharmaceutical products. It also tries to cover the major aspects to be concerned while selecting the wide ranges of designs and statistical tools while employing QbD to a Particular aspect of Pharmaceutical...
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Posted by admin on Aug 31, 2017 in |
In recent years more people throughout world are turning to use medicinal plant products in healthcare system. Worldwide need of alternative medicine has resulted in growth of natural product markets and interest in traditional systems of medicine. Proper integration of modern scientific techniques and traditional knowledge is important. There is a growing focus on the importance of medicinal plants in the traditional health care system (viz. Ayurveda, Unani, Homoeopathy, Yoga) in solving health care problems. Systematic approach and well-designed methodologies for the standardization of herbal raw materials and herbal formulations are developed. The stability testing of herbal products check the quality of herbal products which varies with the time under the influence of environmental factors, such as temperature, humidity, light, oxygen, moisture, other ingredient or excipient in the dosage form, particle size of drug, microbial contamination, trace metal contamination, leaching from the container, etc. and also provide statistics for the determination of shelf lives. Therefore evaluation of the parameters based upon chemical, physical, microbiological, therapeutic and toxicological studies can...
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