Posted by admin on Mar 31, 2017 in |
Scavenger receptor class B member 1 also known as SR-B1 is a receptor that in human is encoded by the SCARB1 gene. SR-B1 functions as a receptor for high density lipoprotein. SR-B1 receptor is mostly found in liver and is best known for its role in facilitating the uptake of cholesteryl ester from HDL in liver. This movement of cholesterol is known as reverse cholesterol transport. Cancerous cells generally have high requirement for cholesterol as they are rapidly dividing cells. HDL acts as carrier for cholesteryl esters and triglycerides. The high affinity of cancer cells for HDL has made HDL useful as carrier for delivering anti-cancer drugs into cancerous cells. So synthetic rHDL particles are designed as carrier for anti-cancer drug owning to their structural features, biocompatibility and targeting capability via receptor mediated mechanism due to which cytotoxic effect of cancer chemotherapeutic drugs on healthy organs can be significantly diminished by employing rHDL as carrier. Drugs incorporated into rHDL were 2.5-23 times cytotoxic to cancer cell than the free...
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Posted by admin on Mar 31, 2017 in |
Asthma is a chronic obstructive disease of airways affecting bronchi, resulting in bronchoconstriction, tightening of chest and airway inflammation. Asthma remains a disease with clearly unsatisfactory therapeutics. With the mounting evidence in support of asthma being an inflammatory illness, anti-inflammatory agents have now become prerequisite for the long-term management of asthma. Along with anti-inflammatory agents, there is a need to search for other effective therapies to treat every aspect of the disease. The present review gives an insight of various approaches available for the management of asthma. A number of drugs are available with chemical diversity as on date for the treatment of bronchospasmolytic conditions. The different sites or receptor involved in this intervention is adrenoceptor, steroid receptor, phosphodiesterase and many more. The agents such as β-agonist, antihistaminics, anticholinergics and inhalation steroids, only treat symptoms and do not cure the underlying inflammation. On the other hand, adenosine receptor modulators, selective PDE4 inhibitors, leukotriene modifiers and lipoxygenase inhibitors represents other therapeutic interventions with more targeted control by acting on different...
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Posted by admin on Feb 28, 2017 in |
The marine environment is a rich source of both biological and chemical diversity. This diversity has been the source of unique chemical compounds with potential for drug development. In recent years, a significant number of novel metabolites with potent pharmacological properties have been discovered from the marine organisms. Specifically, the Red Sea is a natural source of these bioactive compounds. The Red Sea is a rich source of marine organisms that contain bioactive substances with intriguing and unique structural features. Examples of marine organisms commonly found in the Red Sea are sponges, soft corals, and algae. Secondary metabolites obtained from Red Sea marine organisms have been reported to show various biological activities such as: cytotoxic, antiproliferative, antiviral and anti-inflammatory activities. This review emphasizes the bioactivity of marine natural products specifically those isolated from the Red Sea. The present article highlights the latest progress in both chemistry and biological activities of metabolites isolated from Red Sea organisms till year 2014, also it provides a perspective on future areas of research...
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Posted by admin on Feb 28, 2017 in |
Nasal drug delivery has been recognized as a promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that absorption of drugs can enhanced by using absorption enhancers or increasing the drug residence time in the nasal cavity. Mucoadhesive polymers can serve both functions. The residence time in the nasal cavity is considerably increased for microspheres compared to solutions. However, this is not the only factor to increase the absorption of large hydrophilic drugs. Microspheres also exert a direct effect on the mucosa, resulting in the opening of tight junctions between the epithelial cells. This review focuses on the background of nasal mucoadhesive drug delivery with special references to the biological and pharmaceutical considerations for nasal mucoadhesive drug...
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Posted by admin on Feb 28, 2017 in |
Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, during the last forty years. In these analyses, the prominent biomedical applications of ten metallic nanobiomaterials have been reviewed from various sources and works. It has been found that almost nine of them are used in a very wide spectrum of medical and theranostic...
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