Posted by admin on Aug 31, 2017 in |
Retinoids are the derivatives of Vitamin A and have similar action to that of Vitamin A. Sources of Vitamin A such as eggs and meat are known to contain a chemical, retin-A which is known to be useful for treating various dermatological disorders. Tretinoin, a first generation retinoid was first used orally for the treatment of acne in 1940s. Topical tretinoin was later developed as a result of potential adverse effects when given orally and it showed promising therapeutic effect for keratinizing disorders such as actinic keratosis and ichthyosis. Other systemic retinoids such as isotretinoin, acitretin and bexarotene were also studied consecutively which gained approval from US-Food and Drug Administration for a number of keratinisation disorders like acne vulgaris, psoriasis and mycosis fungoides respectively. Along with these disorders, systemic retinoid are widely used for various off label dermatological conditions but due their potentially serious adverse effects, their use has been contraindicated in a number of conditions, especially for pregnant women where it is reported to cause serious embryo-foetal abnormalities....
Read More
Posted by admin on Aug 31, 2017 in |
Norfloxacin is one of the 4-quinolone antibacterials and have many applications in veterinary and human medicine. It is extensively used antibiotic among fluoroquinolone antibiotics in both human and animal welfare. Therefore, the estimation and monitoring of norfloxacin in pharmaceutical preparations and effluents has become a topic of interest for researchers and industries. Existing methods require much time, expenses and sophisticated laboratory facilities. Most of the methods suggest the simultaneous determination of the drug along with the similar groups. There is a thirst among researchers for the development of simple, specific, sensitive and reliable methods suitable for routine laboratory facilities. Most of the methods are based on association of the drug either with metal complexes or reaction with pigments. The main objective of this paper is to review various existing methods for spectrophotometric determination of norfloxacin in order to explore the possibilities to overcome their drawbacks to develop new methods with enhanced simplicity, sensitivity, reproducibility,...
Read More
Posted by admin on Jul 31, 2017 in |
Eessential oils are known to possess antimicrobial activity. This review article explains the antimicrobial reaction, application, effects, and characteristics of cinnamaldehyde. Amongst the different essential oils, Cinnamaldehyde is observed to be the most effective antimicrobial agent. The current studies on cinnamaldehyde in the field of microbiology have been highlighted. This review explains the different methods, those are used for antimicrobial evaluation. Additionally, the anti-physiologic effect of antimicrobial agents using microbial respiration rate is also...
Read More
Posted by admin on Jul 31, 2017 in |
Targeted drug delivery, known as smart drug delivery focuses on targeting the medicaments by increasing the residence time and the concentration of drug at the target site of the body (organs, cells, tissues) thus improving the efficacy of treatment and reducing the side effects. Various carriers that can be used in this type of delivery are liposomes, nanoshells, erythrosomes and resealed erythrocytes. In this Innovation era, resealed erythrocytes have become the choice of drug delivery system because of its excellent biocompatibility, biodegradability and ability to entrap several molecules. The promising aspect of resealed erythrocytes makes them useful as a drug carrier. They have reduced toxicity, improved pharmacokinetic properties that help in transport of active ingredient to the targeted site. This property makes them superior as compared to the conventional drug delivery system. The method of isolation involves collection of sample from the interest, then separating the plasma and finally resealing it. Erythrocytes are prepared by using methods like hypotonic dilution, hypotonic dialysis, pre-swelling, osmotic lysis, endocytosis and chemical penetration....
Read More
Posted by admin on Jul 31, 2017 in |
Seaweeds are not a common weed, its valued marine plants. In Indian coast around around 800 seaweed species belonging to Chlorophyta, Phaeophyta and Rhodhophyta. Seaweeds constitute one of the commercially important renewable marine living resources. Seaweeds have various commercially valuable products such as pharmaceutical and cosmaceutical compounds, plant growth pro-moters, Nitrogen fixers, bio-energy and functional foods. The seaweeds are very rich in nutrition level, because of their low content in lipids, high concentration in polysaccharides, minerals, poly-unsaturated fatty acids and Vitamins as well as their content in bioactive molecules, marine algae are known to be a good source of healthy food. The need for marine natural products like Carrageenan, Kainoids, Polycavernoside A, chondriamides A, B and C have grown enormously in the last fifty years. Especially marine macro algae are wonderful salubrious sources of biologically active natural products. This review highlights the current knowledge of seaweed biotech-nology in the...
Read More
