Posted by admin on May 31, 2017 in |
Tea has been considered as a health promoting drink & stimulant. Globally 4842.1 thousand tons tea consume annually. But due to change in soil characteristics, indiscriminate use of pesticide & fertilizer lead to accumulation of toxic heavy metal like Lead(Pb), Arsenic(As), Copper(Cu), Nickel(Ni) & Cadmium(Cd) in tea leafs & bud. Tea market in India is not well regulated, an abundance of loose tea dust grade leaf very often sell in the local market without any proper labeling and regulatory license no. As this metal have high molecular weight and need more time to eliminate from our body, therefore, serious health ailment like teratogenicity, spontaneous abortion, renal failure & encephalopathy may happen if heavy metal presence in tea leafs & bud above the limit set by different regulatory authorities. In this review, we try to find out the source of heavy metal in the tea garden and differ limit for heavy metal set by major regulatory agencies. Soil, irrigation water, underground water, fertilizer, pesticide & anthropogenic factor influence the accumulation...
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Posted by admin on May 31, 2017 in |
Surgery, chemotherapy and radiation therapy has been the cornerstone of cancer management for decades. Since a decade or so, targeted therapies by way of Imatinib and Trastuzumab arrived that specifically target cancer cells and reply on specific molecular changes to identify them. These are in fact the standard treatment at present in several forms of cancer. But now in recent times, the fifth pillar of cancer treatment has gradually emerged where the patient’s immune system is hired to address and kill his own cancer cells. One such strategy for treatment is involving engineered immune cells of a patient to identify and kill his own tumours. Although this approach, often called adoptive cell transfer or ACT is now limited to small tests and trials, these are seen are true silver bullets in the days to come in treating cancer. This review discuss this new development in pharmaceutical science were living drugs are emerging through high end genetic engineering that exploit the specificity of an antibody and the unique cytotoxic effect...
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Posted by admin on May 31, 2017 in |
Compounds with teratogenic effects can cause genetic defects during pregnancy and subsequently lead to unwanted abortions. Unwanted abortions and postnatal genetic defects can impose economic and psychological burden on the community. This systematic review was conducted to report medicinal plants with teratogenic and abortion-inducing side effects that are used in Iran. To conduct this systematic review, all articles specifically on the teratogenic and abortion-inducing effects of Iranian medicinal plants were retrieved from the Institute for Scientific Information (ISI) and PubMed and their findings evaluated. Many plants have been reported to display teratogenic and abortion-inducing effects, but a limited number of them were experimentally examined and demonstrated to have such effects. Certain plants such as Perovskia abrotanoides and Lawsonia inermis can simultaneously exert teratogenic and abortion-inducing effects. Plants and their derivatives can cause teratogenic effects and lead to unwanted abortion through several action mechanisms. Such plants cannot be considered harmless solely because they are natural; therefore, they should be used during pregnancy cautiously, under physician’s supervision, and at specific...
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Posted by admin on May 31, 2017 in |
Tuberculosis (TB) remains one of the main causes of death from an infectious disease till date. Recent data shows that currently 9.6 million people are infected with TB. Over 95% of TB deaths occur in low- and middle-income countries and it is among the top 5 causes of death for women aged 15 to 44. TB is a leading killer of HIV-positive people and around 1 in 3HIV deaths was due to TB. Furthermore, multidrug-resistant (MDR)-TB and extensively drug-resistant (XDR)-TB is spreading and poses a major threat to progress in global TB control program. The emergence of drug resistant TB strains makes the invention of new molecular scaffold a priority. One of the possible strategies to overcome drug resistance in an economic and simple manner would involve re-engineering and repositioning of some old drugs to obtain derivatives that can work on resistant TB bacilli. These may have enhanced bioavailability, be more effective, and serve as cost-effective substitutes, as compared to new drugs identified through conventional methods of drug discovery and development....
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Posted by admin on May 31, 2017 in |
Liposomes have been established as a promising novel drug delivery vehicle in several different basic sciences. Liposomes are microscopic spheres with an aqueous core surrounded by one or more outer shells consisting of lipids arranged in a bilayer configuration. Liposomes are acceptable superior carriers having ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradation. It also has affinity to keratin of horny layer of skin and can penetrate deeper into skin and hence give better absorption. Liposomes may act as a solublizing matrix for poorly soluble drugs and penetration enhancer when applied on the skin as well as local depot at the same time diminishing the side effects of these drugs. Topical liposome formulations could be more effective and less toxic than conventional formulations. The liposome gel formulations could perform therapeutically better effects than the conventional formulations, as prolonged and controlled release topical dosage forms, may lead to improved efficiency and better patient...
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