Posted by admin on Nov 30, 2016 in |
Aim: The aim of this review is to provide a detailed documentation and main features such as prevalance, manifestations and management regarding Kawasaki syndrome. Background: Kawasaki Syndrome was first described by Dr Tomisaku Kawasaki in Japan in 1967, since then prevalence of Kawasaki syndrome is increasing in all countries as per the reports in journals. This is more prevalent in Asian pacific regions. Kawasaki Syndrome is the most common cause of acquired heart disease in the U.S. and Japan with a high endemic rate of 150 per 100,000 in children less than 5 years. Materials and methods: This is a review based article, thus information regarding the topic was collected from different journals like European journal of paediatrics, Indian paediatrics , AHA scientific council etc. Reason: The purpose of this review is to put forward a well explained article about Kawasaki...
Read More
Posted by admin on Nov 30, 2016 in |
Buddleja asiatica commonly called as butterfly bush is a tender deciduous plant. It is endemic to Asia and found in most parts of India. Traditionally it is used in the treatment of many health disorders such as inflammation, rheumatism, skin disease, malaria etc. In view of pharmacological aspect, Buddleja asiatica is screened for antihepatotoxic, antibacterial, hypotensive, anticancer, antifungal, antimalarial and antioxidant activities. More than 80 compounds including phenyl propanoids, flavonoids, Phenyl ethanoid glycosides, phenylpropanoid esters, non-phenolic compounds, triterpene saponins, iridoid glucosides, benzoates, triterpenoids, monoterpenes, acetogenins, steroids, shikimates as well as other trace elements have been identified in the plant. The flower has a pleasant fragrance and contains many flavonoids including apigenin, acacetin-7-O-β-D-glucoside, diosmin, rutin etc. The lanceolate leaves are rich in essential oil with tridecane, β-caryophyllene oxide, anethole and phytol as major components. This review provides morphological, ethnomedical, pharmacological and phytochemical data of the plant Buddleja...
Read More
Posted by admin on Oct 31, 2016 in |
As the focus of the world is shifting towards natural products and analogues, the demand of herbal medicine is also increasing and several plants have been screened for antifungal activity. Review of literature reports that plant extracts have been mostly screened for activity against human pathogenic bacteria and fungi. Compared to this, there are very few reports regarding inhibitory activity against plant pathogenic fungi. Although there are several reports of antifungal activity of plant products yet not much work has done to develop herbal bio-control agents or formulations using plant products or extracts. Herbal Products are cheaper than chemicals with minimal or practically no adverse side effects on hosts. Eucalyptus globulus extract has been screened for antifungal activity against human pathogenic fungi and bacteria but very few reports are available regarding plant pathogenic fungi especially early blight caused by Alternaria solani. Antifungal activity of organic substances has been reported by some workers but no study till date has been reported on preparation of herbal formulation by combining plant powder,...
Read More
Posted by admin on Oct 31, 2016 in |
Capecitabine an oral prodrug of 5- fluorouracil is widely used for the treatment of variety of solid tumors, particularly colorectal cancer. However it is not devoid of toxicities and may limit therapy. A little is known about predictors of toxicity, response and survival in patients treated with capecitabine. The pharmacogenetic testing methods can identify such variants and thus indicate those patients who are at risk for adverse effects with capecitabine. Various studies have been carried out to assess the various genetic predictive and prognostic markers with treatment. The purpose of this review is to describe the comprehensive reports and draw conclusion with the available information on capecitabine pharmacogenetics and future directions on ongoing research. An extensive literature search was carried out on the genes encoding the enzymes involved in the metabolism of capecitabine. Overall, evidence indicates multiple genes associated with the response/toxicity with capecitabine therapy, however majority of reports indicate DPD deficiency as a source of life-threatening toxic effects. Hence, prospective studies correlating the enzymes and the concentration of...
Read More
Posted by admin on Oct 31, 2016 in |
Targeted delivery system is a promising strategy for improving cancer treatment and diagnostics. Molecular targeted drug delivery system has the potential to maximize the cancer treatment efficacy and minimize the toxicity to normal cells. Folate receptor (FR), an established ovarian cancer marker, is frequently found to be overexpressed in other major epithelial tumors. Overexpression of FR- β in myeloid leukemi as & in inflammatory macrophages, including tumor associated macrophages indicates exploitation of FR for targeted drug delivery. Active research taking place in the field of FR based tumor drug targeting has led to development of FR targeted radioimaging agents and chemotherapeutic agents of highly significant value in the field of oncology. FR is targeted by using conjugates of folic acid or anti FR antibodies. Though, both these techniques have their own advantages & disadvantages. To date, promising folate targeted antibodies, Farletuzumab & the low molecular weight folate conjugates like EC20, EC145 etc. have moved from phase II to phase III trials. This review focuses on all the developments made...
Read More
