Posted by admin on Apr 30, 2017 in |
Piperidine is a key structural motif in various alkaloids and a variety of compounds studied in medicinal chemistry. Though many methods have been developed for their construction, there is still need for noval approaches. Among the wide variety of heterocyclic compounds; piperidin-4-ones exhibit various biological activities. Synthesis and biological applications of piperidin-4-ones derivatives are outlined in this...
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Posted by admin on Apr 30, 2017 in |
Endodontic treatment is helpful in saving millions of teeth each year, but at present the focus has shifted towards regenerative approaches as an ideal form of therapy to treat diseased or necrotic pulp tissues. Regeneration of lost tissues has been known for a very long time, but their use in dentistry is gaining momentum. The growing understanding of biological regeneration has permitted the use of stem cells for regeneration and revascularisation 1. The dental pulp contains a small sub population of stem cells that respond against caries progression and also secrete factors that have the ability to induce revascularization of pulp 2. Stem cells re-search and scaffolding are the frequently used words in basic science pulp researches at present. Several techniques with their individual advantages, disadvantages and uses are being performed 3. In the past few years, many studies regarding stem cells and tissue engineering have been done giving rise to a separate branch called Regenerative Dentistry 4. Regenerative Endodontics uses the basic logic that the patient specific tissue...
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Posted by admin on Apr 30, 2017 in |
Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. Natural products from plant, animal and minerals have been the basis of the treatment of human disease. Capsicum plants belongs to the family Solanaceae and kingdom Plantae, consist of 27 species, and approximately 3000 varieties. Chili peppers are used worldwide in foods for their pungent flavor, aroma, and to prolong food spoilage. With capsaicin contents ranging from zero to millions of Scoville heat units, the different varieties offer a wide range of options for people all over the world. The aim of present review is to form a short compilation of the pharmacological and toxicological potentials of this multipurpose fruit. Capsicum, has been used as anti-inflammatory, anti-diabetic, anti-cancer, anti-ulcer, anticoagulant, analgesic, anti-arthritis, immuno-modulatory, memory enhancing, pain relief, hypocholesterolaemic, hypolipidemic, hepatoprotective and antimicrobial effects. It also cause irritation to mucous membrane, inflammation and neurotoxicity. It should not be used on open wounds or abrasions, or near the eyes. It has antagonistic effects on of α-adrenergic blockers,...
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Posted by admin on Apr 30, 2017 in |
Statistical figures represent that fungal infections are the major cause of thousands of deaths each year. Despite the availability of treatment options invasive and systemic fungal infections have alarmingly higher mortality rates. This current review tabulates such fungal organisms that are pathogenic and fatal to human. This article provides a compilation of all Mycoses in human and also reports about the risk group of each fungus based on which, the level of risk caused by fungi can be determined. Infections caused by Dimorphic fungal pathogens (Blastomyces, Coccidioides, Marneffei) and Dematiaceous hyphomycetes (Cladophialophora, Rhinocladiella) belong to major fatal causing risk group 3 resulting in higher death rates of individuals. It also reports about various types of possible classification of mycoses i.e. based on reaction of human to fungi, host susceptibility, pathogen type, body location and risk group. The article highlights the estimated incidence of fungal diseases due to these pathogens, but these statistical figures are usually underestimated so there is a great need for advancement in understanding of fungus, their...
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Posted by admin on Apr 30, 2017 in |
Allergic rhinitis is a common disease of immune system that negatively affects general health, quality of life, and social relationships. In the recent years, many studies have been conducted to discover novel treatments for this disease particularly using natural products. Here, we review findings of recent studies that harness medicinal plants and phyto-therapies in oriental medicine that have effectively reduced allergic rhinitis complications. We also assess the use of medicinal plants and their derivatives in oriental medicine to treat allergic rhinitis. In addition, these agents have been reported to be used in combination with each other or separately as complementary therapies and even, in some cases, alternative therapies instead of chemical drugs. These plants display their anti-allergy effects through affecting immunoglobulin and inhibiting different cytokines and interleukins. Medicinal plants and traditional approaches can still offer new therapeutic alternatives to researchers and pharmacists so that these alternatives may further contribute to allergic rhinitis drug...
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