Posted by admin on Sep 30, 2016 in |
Stroke remains world’s second leading cause of mortality; and globally most frequent cause of long-lasting disabilities. The ischaemic pathophysiologic cascade leading to neuronal damage consists of peri-infarct depolarization, excitotoxicity, inflammation, oxidative stress, and apoptosis. Despite plethora of experimental evidences and advancement into the development of treatments, clinical treatment of acute stroke still remains challenging. Neuro-protective agents, as novel therapeutic strategy confer neuro-protection by targeting the pathophysiologic mechanism of stroke. The aim of this review is discussion of summary of the literature on stroke pathophysiology, current preclinical research findings of neuroprotective agents in stroke and possible factors that were responsible for the failure of these agents to translate in human stroke...
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Posted by admin on Sep 30, 2016 in |
Flavonoids are the natural compound widely distributed in plant kingdom, it is responsible for the various colors exhibited by bark, leaves, flowers, fruits and seeds of plants. They are the secondary metabolites of plant with significant antioxidant properties. Flavonoids have antioxidant, sedative, antidepressant, anticonvulsant, anti-proliferative, anti-inflammatory, anti-microbial, anticancer, cardioprotective, antihypertensive, antiulcerogenic, antidiabetic and hepatoprotective activity. Many researchers have revealed that the above mentioned pharmacological actions are mainly due to its antioxidant property. Flavonoids have effect on mammalian enzymes like protein kinases, alpha-glucosidase and aldose reductase, thereby regulate multiple cellular signaling pathway that were altered during disease conditions. Various researches on flavonoids are in progress due to its versatile health benefits. En number of flavonoids are available in the market as pharmaceutical products because of its cost effective bulk production and health benefits. The present review is focused on the classification, metabolism, pharmacological and biological actions and flavonoid supplement available in...
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Posted by admin on Sep 30, 2016 in |
Man has been dependent on plants for the treatment and cure of different diseases since time immemorial. Plants have served not only as a source of food and shelter but also as a very important source of different “portions” used for the treatment and cure of diseases. These portions are herbal or plant based mixtures made by traditional healers; who are individuals having a knowledge of medicinal plants of that particular area. In India, there are several thousands of medicinal plants, known to be used for specific diseases. Canavalia virosa is one such plant, known to be used for different curative purposes. However, it is more popular as a food plant as it is a tribal pulse. Canavalia virosa is a flowering plant belonging to the family Fabaceae. It is one of the lesser know vines from the genus Canavalia. It is not only important as an alternative protein source but also a promising medicinal plant as indicated by traditional medicine systems. This paper brings together some of the...
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Posted by admin on Aug 31, 2016 in |
Herbal immunomodulator is substance which stimulates or suppresses the components of immune system including both innate and adaptive immune responses. The modulation of immune system by various medicinal plant products has become subject for scientific investigations currently worldwide. A number of Indian medicinal plants and various ‘Rasayana’ have been claimed to possess immunomodulatory activity. Some of these plants are, Allium sativum, Morus alba, Acacia catechu, Tinospora cordifolia, and Mangifera indica. A lot more are still to be explored and offer scope for further...
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Posted by admin on Aug 31, 2016 in |
An antibiotic may be defined as a substance or compound that kills or inhibits the growth of, bacteria. Antibiotics belong to the broader group of antimicrobial compounds, used to treat infections caused by microorganisms, including fungi and protozoa, viruses. Antibiotic de-escalation is a mechanism whereby the provision of effective initial antibiotic treatment is achieved while avoiding unnecessary antibiotic use that would promote the development of resistance. The embodiment of de-escalation is that based on microbiology results around the day 3 therapy point; the empiric antibiotic(s) that were started are stopped or reduced in number and/or narrowed in...
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