Posted by admin on Oct 31, 2016 in |
As the focus of the world is shifting towards natural products and analogues, the demand of herbal medicine is also increasing and several plants have been screened for antifungal activity. Review of literature reports that plant extracts have been mostly screened for activity against human pathogenic bacteria and fungi. Compared to this, there are very few reports regarding inhibitory activity against plant pathogenic fungi. Although there are several reports of antifungal activity of plant products yet not much work has done to develop herbal bio-control agents or formulations using plant products or extracts. Herbal Products are cheaper than chemicals with minimal or practically no adverse side effects on hosts. Eucalyptus globulus extract has been screened for antifungal activity against human pathogenic fungi and bacteria but very few reports are available regarding plant pathogenic fungi especially early blight caused by Alternaria solani. Antifungal activity of organic substances has been reported by some workers but no study till date has been reported on preparation of herbal formulation by combining plant powder,...
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Posted by admin on Oct 31, 2016 in |
Capecitabine an oral prodrug of 5- fluorouracil is widely used for the treatment of variety of solid tumors, particularly colorectal cancer. However it is not devoid of toxicities and may limit therapy. A little is known about predictors of toxicity, response and survival in patients treated with capecitabine. The pharmacogenetic testing methods can identify such variants and thus indicate those patients who are at risk for adverse effects with capecitabine. Various studies have been carried out to assess the various genetic predictive and prognostic markers with treatment. The purpose of this review is to describe the comprehensive reports and draw conclusion with the available information on capecitabine pharmacogenetics and future directions on ongoing research. An extensive literature search was carried out on the genes encoding the enzymes involved in the metabolism of capecitabine. Overall, evidence indicates multiple genes associated with the response/toxicity with capecitabine therapy, however majority of reports indicate DPD deficiency as a source of life-threatening toxic effects. Hence, prospective studies correlating the enzymes and the concentration of...
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Posted by admin on Oct 31, 2016 in |
Targeted delivery system is a promising strategy for improving cancer treatment and diagnostics. Molecular targeted drug delivery system has the potential to maximize the cancer treatment efficacy and minimize the toxicity to normal cells. Folate receptor (FR), an established ovarian cancer marker, is frequently found to be overexpressed in other major epithelial tumors. Overexpression of FR- β in myeloid leukemi as & in inflammatory macrophages, including tumor associated macrophages indicates exploitation of FR for targeted drug delivery. Active research taking place in the field of FR based tumor drug targeting has led to development of FR targeted radioimaging agents and chemotherapeutic agents of highly significant value in the field of oncology. FR is targeted by using conjugates of folic acid or anti FR antibodies. Though, both these techniques have their own advantages & disadvantages. To date, promising folate targeted antibodies, Farletuzumab & the low molecular weight folate conjugates like EC20, EC145 etc. have moved from phase II to phase III trials. This review focuses on all the developments made...
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Posted by admin on Oct 31, 2016 in |
Histone deacetylase inhibitors (HDACIs) are a group of agents that have exhibited antitumor activity in vivo and in vitro, directing to clinical trials estimating their efficacy in multiple cancer types. Belinostat is under global development with Spectrum Pharmaceuticals, currently approved by the U.S. Food and Drug Administration with indications for relapsed or refractory peripheral T-cell lymphoma on July 2014 and is under regulatory review in the Europe. Belinostat has been investigated as a single agent and in groups with further chemotherapies and biological agents, in the management of solid tumors and lymphoma. The main side effects are pyrexia, pneumonia, anemia, thrombocytopenia, neutropenia and fatigue, which are manageable. Belinostat is also being investigated in patients with bladder cancer, prostate cancer, solid tumor, mantle cell lymphoma, refractory advanced thymic epithelial tumors, pancreatic cancer and ovarian cancer. This article reviews the obtainable information on Belinostat with respect to its clinical pharmacology, mechanism of action, pharmacodynamics, pharmacokinetics, metabolism, preclinical studies and clinical...
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Posted by admin on Oct 31, 2016 in |
Hunteria is a genus of plant in family Apocynaceae. It comprises of 12 species but more prevalent are Hunteria umbellata and Hunteria zeylanica. Taditionally H. umbellata have been used in the treatment of yaws and sexually transmitted infections, stomach ache, ulcers, diabetes mellitus and dysmenorrhoea. H. zeylanica is used to cure profile but its prolonged use, particularly, at high doses should be with great caution. The phytochemical analysis of the H. stomach-ache, wounds and cuts. H. umbellata has a relatively low oral toxicity umbellata plant extract revealed the presence of saponins, steroids, tannins, volatile oils, phenols and copious amount of alkaloids. H. zeylanica leaves and stem bark prominently contains alkaloids. Scientific researchers have shown that H. umbellata and H. zeylanica were active against various diseases such as bacterial infections, pain, fever, inflammation, diabetes, in obesity, hyperlipidemia, heart problems, in child birth and malaria. Aim of the current review is to explore potential species of Genus Hunteria for ethnopharmacology, toxicological studies, safety, phytochemical investigation and pharmacological...
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