Posted by admin on Dec 31, 2015 in |
Over the past few decades, the pursuit and exploration of nanotechnology is likely to have a significant impact on the drug-delivery system. This technology can be envisioned as playing a major role in revolutionizing the future of novel drug delivery system. Nanoparticles (NPs) are one of them which have many potential applications in clinical medicine and research. The encapsulation of therapeutic drugs in the form of nanoparticles shows advantageous effect over their corresponding drugs such as increases drug efficacy, specificity, tolerability and therapeutic index. The current review article focuses on the different nanoparticulate drug-delivery systems including nanoerythrosomes, Superparamagnetic nanoparticles, liposomes, Quantum dots, ceramic nanoparticles and dendrimers as well as their applications in different...
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Posted by admin on Dec 31, 2015 in |
objectives: Nelumbo nucifera Gaertn (Nelumbonaceae) known by numerous common names including Indian lotus, sacred lotus, bean of India, or simply lotus is one of the most important medicinal plants. In this review there is discussion about therapeutic potential of the different parts of the plant (leaves, seeds, flower, and rhizome) which can be used in traditional system of medicine. This review also describes various compounds isolated from different parts of the plant and therapeutic benefits derived from those phytocontituents. The aim of this review is to summarize the pharmacological, phytochemical and therapeutical knowledge of Nelumbo nucifera Gaertn. Key findings: The pharmacological studies have shown that N. nucifera possesses various pharmacological activities like anti-ischemic, antioxidant, anticancer, antiviral, antiobesity, lipolytic, hypocholestemic, antipyretic, hepatoprotective, hypoglycemic, antidiarrhoeal, antifungal, antibacterial, anti-inflammatory and diuretic activities. Several different types of compounds have been derived from this plant belonging to different chemical groups, including alkaloids, flavonoids, glycosides triterpenoid, etc., with own therapeutic impact. So the pharmacological effects and various active ingredients of different parts of N. nucifera...
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Posted by admin on Dec 31, 2015 in |
Quinoline and its derivatives are diverse pharmacological agents. They play a vital role in the development of new therapeutic agents. Many new therapeutic agents have been developed by using quinoline nucleus. Hence quinoline and its derivatives constitute an important class of heterocyclic compounds for the new drug development. Quinoline is also known as 1-azanapthalene and many researchers have synthesized large number of quinoline derivatives. Different synthetic routes have been developed by these researchers for the synthesis of quinoline derivatives. These derivatives have also been evaluated for the relevant biological activity by in vitro as well as in vivo methods. The present review focuses on detailed work done so far on the quinoline and its derivatives in the search of new therapeutic agents. The review covers the synthesis as well as biological activities of quinoline derivatives such as antimalarial, anticancer, antibacterial, anthelmintic, antiviral, antiprotozoal, antifungal, anti-inflammatory, analgesic, cardiovascular, reproductive, central nervous system activity, hypoglycemic and miscellaneous...
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Posted by admin on Dec 31, 2015 in |
Type 2 diabetes is a serious health problem globally. In type 2 diabetes insulin resistance in various tissues such as liver, muscle and β-cell is the major pathophysiological defects. People with long term uncontrolled hyperglycemia are at risk of developing a number of serious and life-threatening complications which mainly affect the heart and blood vessels, eyes, kidneys, and nerves. Current drug development strategy has focused towards the control of hyperglycemia but the treatment of severe complications has been neglected. Many herbs including Momordica charantia, Coccinia indica, Ficus carica, Gymnema sylvestre, Ocimum santum and many more have traditionally been used for the treatment of diabetes and associated complications. Natural products have been reported to have their efficacy in diabetes and its complications by protecting pancreatic β-cells, increasing insulin sensitivity, reducing oxidative stress and by targeting various proteins. Thus, now a day plant based natural product (phytoconstituents) have been the basis of drug development program for the treatment of various diseases. The present review summarizes the latest updates on phytochemicals from...
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Posted by admin on Dec 31, 2015 in |
In Ayurveda, there are less toxic herbal drugs known as upavisha. Upavisha are mostly use in various diseases with many therapeutically preparations. As per Ayurveda, Upavisha is group of less toxic drug. These drugs are either not having all ten gunas or they have less potent gunas. The properties of these drugs are to cure acute and chronic disease. These groups also have antimicrobial/ anti- infective activity. Ayurvedic formulation having these drugs can be used in various microbial disorders. The classical preparations of all upavisha are indicated in mostly chronic ailments, vatavikara, neuromuscular disorder, gastrointestinal disorder and skin...
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