Posted by admin on Nov 30, 2015 in |
This article mainly focuses on the approval process of drug import and export from India. Now a day’s foreign pharmaceutical companies have a better legal foundation for releasing new drugs in India. The Indian medical regulatory system has become more complicated, and new drugs can take a year or more to be approved for marketing. Ever-changing laws and regulations are driving demand for regulatory affairs professionals to provide the current needs of industries for the global competition and who can help pharmaceutical companies to effectively bring their medical products to the Indian market. In today’s competitive scenario, the reduction of the time taken to launch the product is imperative and hence vital for company’s success. This article will be helpful to all pharma manufacturer/importer, regulatory, preclinical, formulation scientists, and clinical trial professional who are involved directly or indirectly in new drug registration process. Need integrated knowledge and broad perspectives which you need to effectively manage the regulatory process for approval of new drugs in...
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Posted by admin on Nov 30, 2015 in |
The liver is a vital solid organ in the upper abdomen that helps in digestion, detoxification and has other synthetic, metabolic and storage functions. Liver diseases are a major problem worldwide; viral hepatitis, alcohol, malnutrition, autoimmune and drugs being most important causes. Currently there is no way to compensate for the absence of liver function in the long term and liver transplant is the only option for those with irreversible loss of hepatic function. The scientific basis for the statement that plants and their active constituents play an important role in the prevention of diseases is continuously advancing. In this review some of the plants with their phyto-constituents studied for protective effect in liver diseases are...
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Posted by admin on Nov 30, 2015 in |
In the last few years, there has been an exponential growth in the field of herbal medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects. The World Health Organization (WHO) has listed 21,000 plants, which are used for medicinal purposes around the world. Among these 2500 species are in India, out of which 150 species are used commercially on a fairly large scale. India is the largest producer of medicinal herbs and is called as botanical garden of the world. In this study, we intend to do a systematic search to identify the most potent antidiabetic herbs that are available in India. Relevant medical databases and websites were searched. To qualify for inclusion, the herbs should have excellent antidiabetic potential confirmed with biomarker (reduction in HbA1c) and the herbs should also possess limited adverse effects if at all any. Eligible studies must also meet the following criteria: published in English and peer-reviewed journals. We also used...
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Posted by admin on Nov 30, 2015 in |
Polysaccharides obtained from gums and mucilages are extensively used natural materials for conventional and novel dosage forms. Many natural gums are studied for use in novel drug delivery systems out of which polysaccharides, resins and tannins are most extensively studied and used. Because of advances in drug delivery technology, natural polysaccharides are included in novel drug delivery to fulfil multitask functions and in some cases directly or indirectly control the extent or rate of drug release. Regular research is going on in the field of use of naturally occurring biocompatible polymeric material in designing of dosage forms for oral controlled release administration. The natural polysaccharides improve the national economy by providing inexpensive formulations to people, by using locally available materials. The present review covers almost all the areas of interest of some very important naturally based polysaccharides, natural gums and mucilages with their sources, chemical constituents, chemical structures, isolation, purification, standardization and characterization along with their uses in various pharmaceutical...
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Posted by admin on Nov 30, 2015 in |
Etoposide is an antineoplastic agent employed for healingvarious malignancies in human. It is a semi-synthetic derivative of podophyllotoxin and was introduced in 1971. The primary mode of action of etoposide is the inhibition of the function of the enzyme topoisomerase II. It stabilizes DNA-enzyme complex, and accumulation of this complex enhances the probability of double-stranded DNA breaks. However, etoposide can also causes DNA lesions in cancerous cells. This genotoxicity and antineoplastic activity of drug at the same time serve as the impetus for intensive research. Etoposide treatment causes permanent DNA breaks pertaining to its significant role in cell death and growth arrest in tumor cells. This review attempts to provide the deep knowledge of its possible biochemical pathways which are triggered in response to DNA breaks and leads to apoptosis and cell cycle arrest as well transcriptional activation of various death receptors. Molecular mechanism of drug efflux and activation of repairing proteins which can cause resistance in its action are also discussed. This current picture of known facts serve...
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