Posted by admin on Jul 31, 2016 in |
Diabetes mellitus is the common metabolic disorder seen in 2.8% of the world’s population. It is expected to cross 5.4% by 21st century. It is one of the causes of death in this 21st century. Since many years, herbal medicines are used as a source of medicine in Ayurveda and also in some traditional systems of medicine. Ayurveda and other traditional systems have textual evidence about the uses of medicinal plants to cure various types of diabetes in human beings. Thousands of plant species has shown the therapeutic efficacy to control diabetes. As the usage of natural medicinal plants can have lesser side effects when compared with the synthetic drugs. This review mainly aims to know about various plant species in India and all around the world that are used in curing Diabetes...
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Posted by admin on Jul 31, 2016 in |
Statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhibitors, are considered safe in lowering hyperlipidemia and cardiovascular disease. Statin attempt to reduce cholesterol production in liver in dose dependent manner not only cause the muscle related problem but also leads to other untoward consequence like arthritis, diabetes, neurological disorders which arise as a result of scarcity in cholesterol production. Discontinuation or reduction in the dose of the statin usually leads to resolution of these side effects but the efficacy is questionable. Though the statin had come to market several decades ago, their harmful effects have been well understood very recently only after several randomized trials. The pleiotropic effects of statin have reported many benefits, but lack of randomized clinical trials make it limit to extend its indication beyond lipid lowering effects. There is still a controversy between their benefits and adverse effects of statin. The upcoming research should focus to resolve the above said confliction that could overcome its most adverse events- myopathy. If it so the statin with pleiotropic effect without...
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Posted by admin on Jul 31, 2016 in |
Nanosized fluorescent carbon particles, carbon dots (CDs), are a kind of fluorescent material that has many applications in recent years. They have biological application like delivery of therapeutic payloads for cancer therapy mainly due to their biocompatibility and unique optical properties. Fluorescent carbon dots overcome the short comings of high toxicity of traditional nano materials. Moreover, the preparation procedure of fluorescent carbon dots is simple and easy. Therefore, fluorescent carbon dots have great potential applied in photocatalysis, biochemical sensing, bioimaging, drug delivery and other related areas. Many functional groups or passivation agents are used to cover the surface of the CDs outside the carbon core, to make CDs with high quantum yield (QY), chemical stability and good water solubility. CDs can be easily conjugated with target molecules to expand their functionality. These traits make them an ideal alternative to semiconductor quantum dots such as CdTe and CdSe. Amoung multi-coloured fluorescent carbon dots, green CDs(GCDs) shows high potential in biological labelling and...
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Posted by admin on Jul 31, 2016 in |
The growing impact of infections caused by dermatophytes i.e. Trichophyton, Microsporum and Epidermophyton is not upto the mark in their treatments via conventional methods due to resistance, side effects, and high toxicity. Over prescription and overuse of traditional antifungal agents, high side effects, less eco-friendly nature, high manufacturing costs, high management costs etc., have stimulated the research for alternative natural drugs, such as herbal extract, essential oils and some commercially available compounds. This paper reviews the antidermatophytic activity of various commercially available and conventionally available herbals from different plants and their major role in prevention of prevalent strains dermatophytes. The mode of action of dermatophytes for causing dermatophytosis as well as mode and mechanism of action of various antifungal agents (herbals extracts, oils, suspensions and commercially available compounds) have also proposed. In vitro susceptibility tests and in vivo models used in antidermatophytic assays as well as the mechanism of action of dermatophytes are involved under the perspective of the potential use of herbals as antifungal agents in the clinical...
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Posted by admin on Jun 30, 2016 in |
Microsponge is recent novel technique for control release as well as target specific drug delivery system. Therefore many researchers are attracted towards the microsponge drug delivery system. Microsponge technology has been introduced in topical drug products to increase the controlled release of active drug into the skin in order to reduce entry of drug in blood and maintain drug on skin surface. Microsponge technology offers entrapment of ingredients, improved stability, reduced side effects, increased elegance, and enhanced formulation flexibility. Various studies have shown result that microsponge systems are non-irritating, non-allergenic, nonmutagenic, and non-toxic. This technology is used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens and prescription products. This technology has the best feature that it is self-sterilizing. In this article we focused on method of preparation, characterization (Particle size and its distribution, surface morphology, porosity, density are covered), advantages, disadvantages and application of...
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