Posted by admin on Apr 30, 2025 in |
Alzheimer’s disease (AD) is an irrevocable most run-of-the-mill neurodeteriorating disease which comprises of lapses in the memory due to the disfigurement of synapse & neurons that leads to numerous types of dementia. As per the outline via (WHO) ICD-10 Mental & Behavioural Classification of Dementia, AD is persuaded by distinctive peculiarities of encephalon by either accretion of Amyloid-β, Neurofibrillary tangles, Insulin Resistance or Free radical generation. On top of that, genetic alteration in TREM-2 modified macrophages in encephalon depicts vast clinical manifestations according to different scalings with scorings. These scores are given by dint of the symptoms evinced with the help of newly retrieve diagnosis markers to prevent the wild mood disorder complications alongside rare organ failures. The numerous methodologies are great headways that makes a grateful resulting impact in the field of AD. Ahead of the times information & a wholistic perspective towards holistic malady can make a great avenue to recuperate in bucket of psychogenic...
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Posted by admin on Apr 30, 2025 in |
The use of biosensors and devices as instruments for health, education, and prevention has garnered a lot of attention in recent years. Personalized therapy depends on accurate and timely monitoring of biological markers and drug effectiveness, which is made feasible by biosensing devices in medications. The creation of the first real biosensor for oxygen sensing touches on the idea of biosensors. The “Web of Science” database had over 84,000 articles regarding “biosensors” between 2005 and 2015. Today, the field of research connects the foundations of electronics, micro/nanotechnology, applied medicine, and the basic sciences (physics, chemistry, and biology). The three primary components of a biosensor a bioreceptor, a transducer, and a signal processing system as well as the principles behind the various biosensor types are the main topics of the review. Additionally, the paper outlines several instances of biosensors being utilized to treat a range of illnesses, including infectious infections, diabetes mellitus, cardiovascular disease, and Alzheimer’s disease. Biosensors have several uses, many of which are intended to improve people’s quality...
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Posted by admin on Apr 30, 2025 in |
Artificial intelligence (AI) is rapidly transforming the drug development process, offering innovative solutions to streamline and accelerate the discovery of new therapeutics. Traditionally, drug development has been a time-consuming and costly endeavor, often taking over a decade and billions of dollars to bring a drug to market. AI, with its ability to analyze vast amounts of complex data, has the potential to significantly reduce both time and costs while improving the success rate of new drugs. AI techniques, including machine learning (ML), deep learning (DL), and natural language processing (NLP), are being integrated at various stages of the drug development pipeline. In the early stages, AI is used to analyze large datasets, such as chemical, genomic, and proteomic data, to identify potential therapeutic targets and biomarkers. Machine learning algorithms can also predict a compound’s biological activity, optimizing lead compounds and enhancing virtual screening compared to traditional methods. Advanced AI methods, such as generative models and reinforcement learning, are being applied to design new molecules with desired properties, improving drug...
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Posted by admin on Apr 30, 2025 in |
Personalized medicine represents a transformative approach in healthcare, particularly in dermatology, where treatments are tailored to individual patient profiles. Microsponges, as advanced drug delivery systems, offer significant advantages in this context by enhancing the efficacy and safety of topical treatments. This review explores the fundamentals of microsponges, their mechanisms of drug loading and release, and their compatibility with various active ingredients. It further examines the concept of personalized medicine, emphasizing its benefits in optimizing dermatological therapies. By detailing strategies for customizing microsponges based on patient characteristics and showcasing relevant clinical applications, this paper highlights the clinical implications of personalized microsponges in managing skin disorders such as acne, psoriasis, and eczema. Additionally, the review addresses the challenges and barriers to implementing personalized microsponges, including technical, regulatory, and economic considerations. Future perspectives on emerging trends and innovations in microsponges are discussed, underscoring their potential to revolutionize personalized topical therapies. This paper aims to provide insights into the integration of microsponges in personalized medicine, fostering further research and collaboration in the...
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Posted by admin on Apr 30, 2025 in |
This review explores the intricate physiology of urine formation and its critical relationship with chronic kidney disease (CKD). Urine formation involves three key processes: glomerular filtration, tubular reabsorption, and tubular secretion, which work together to maintain homeostasis by regulating fluid balance and waste elimination. In CKD, these functions are impaired due to progressive damage to the nephrons, leading to a reduced glomerular filtration rate (GFR) and accumulation of toxic metabolites, which contribute to a variety of complications including hypertension, electrolyte imbalance, and fluid overload. Understanding the mechanisms underlying urine production provides important insights into the pathophysiology of CKD and highlights the importance of early detection and treatment strategies. This review aims to highlight the importance of preserving renal function and improving treatment outcomes in patients with CKD by reviewing current research and clinical...
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