Posted by admin on Oct 31, 2015 in |
Diabetes is the most common lifestyle disease associated with many serious worries including diabetic ketoacidosis, cardiac problems, kidney failure, non ketotic hyperosmolar coma, foot ulcers, eye damage etc. All these complications develops due to abnormalities in carbohydrate metabolism and insulin synthesis resulting in high blood sugar with symptoms such as elevated hunger and thirst, polyuria, glycosuria, lethargy etc. The article is focused on different targets of diabetes....
Read More
Posted by admin on Oct 31, 2015 in |
C-phycocyanin (C-PC) is a biliprotein found in edible blue-green algae. Its anti-cancer, anti-inflammatory, anti-proliferative and anti-oxidant activities has been evidenced by many in vitro and in vivo studies. Anti-inflammatory activity of C-PC demonstrated by free radical scavenging, inhibition of DNA damage, and decreased ROS. Here, the effects of C-PC on cytotoxicity and cell signaling through the apoptotic and other pathways were studied. Results indicated that anti-proliferative effects of C-PC are mediated by inactivation of BCR-ABL signaling and the downstream pathway PI3K/AKT. Phycocyanin induces apoptotic death, and Bcl-2 expression inhibits it via generation of free radicals. C-PC exerted antimelanogenic mechanisms by downregulating p38 MAPK-regulated CREB pathway activation and upregulating MAPK/ERK-dependent degradation of MITF protein. C-PC-mediated PDT (photodynamic therapy) is approved as a potential therapy for cancer. Phycocyanin can be consumed as a dietary supplement or a food component to obtain health benefits against CVD (cardiovascular disease) and NAFLD (non-alcoholic fatty liver disease). These results suggest that phycocyanin which had been obtained from blue green algae are potential medicaments in the...
Read More
Posted by admin on Sep 30, 2015 in |
Turmeric is a spice derived from the rhizomes of Curcuma longa, which is a member of the ginger family (Zingiberaceae). Turmeric constituents include the three curcuminoids: Curcumin (diferuloylmethane; the primary constituent and responsible for its vibrant yellow color), demethoxycurcumin, and bisdemethoxycurcumin, as well as volatile oils (tumerone, atlantone, and zingiberone), sugars, proteins, and resins. In the Ayurvedic tradition, turmeric, or “haldi” as it is known in Hindi. Turmeric is considered to be one of the most important herbs in the ayurvedictradition and used historically as a component of Indian Ayurvedic medicine since 1900 BCE to treat a wide variety of ailments including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, and liver disorders. Extensive research in the latter half of the 20th century has identified curcumin as responsible for most of the biological activity of turmeric. Curcumin has been shown to exhibit anti-oxidant, anti-inflammatory, anti-viral, anti-bacterial, anti-fungal, anti-cancer hyperlipidemic, woundhealing and hepato- protective activities and thus has a potential against various malignant diseases, diabetes, allergies,...
Read More
Posted by admin on Sep 30, 2015 in |
In the last few years there has been an exponential growth in the field of herbal medicine and these drugs are obtaining popularity both in developing and developed countries because of their natural origin and lesser side effects. Many traditional medicines in use and they are derived from medicinal plants, minerals and some organic matter. The World Health Organization (WHO) has listed 21,000 plants, which are useful for medicinal purposes around the world. Among these 2500 species are in India, out of which 150 species are used commercially on a fairly large scale. India is the largest producer of medicinal herbs and is called as botanical garden of the world .This review focuses on herbal drug preparations of nanoformulation used in the treatment of different chronic diseases conditions in the world. This paper will discuss the benefits with use of herbal nanoformulation as Anti-cancerous activity. The application of nanotechnology is enhancement for the bioavailability and nanomization of herbal drugs like-nanocurcumin from Curcuma longa, nanovincristine from Vinca rosea, Podophylotoxin from...
Read More
Posted by admin on Sep 30, 2015 in |
Ensuring patient safety during and after clinical trials is the sole priority of the drug-development process. In both clinical trials and clinical practice, each patient must be treated according to his or her illness and needs. For this purpose, monitoring of patient safety at all levels of drug-development is given utmost importance. Such monitoring is a dynamic process having motive of protecting trial volunteers and patients from preventable harm during and after clinical trials respectively. For this purpose, knowledge of the basics of drug safety at all levels is essential especially for the healthcare professionals. Many literatures have been published on drug safety and clinical trials but a systemic document focusing strictly on all the dimensions is lacking. In this article, we have discussed upon all aspects of drug safety in clinical trials including the basics of drug safety, patient suitability for safety in trials, regulatory aspects of drug safety, causality, risk assessment and post marketing safety of the drug...
Read More
