Posted by admin on Apr 30, 2016 in |
The Genus Costus (Linn.) is an important medicinal plant belonging to the family Costaceae. The Genus as a whole is often called Spiral Ginger. The genus is represented by about 175 species distributed throughout the world. The aerial parts of the plant and the rhizomes are edible, the rhizome being good source of carbohydrate, starch, amylase, protein and lipid. Moreover the rhizome is an alternative source of diosgenin and generally used to control diabetes. Rhizome of Costus is also used for curing many other ailments. In Ayurveda, the rhizomes are ascribed to be astringent, acrid, cooling, aphrodisiac, purgative, anthelmintic, depurative and expectorant. The present study focuses on the nutritional and pharmacological importances of Costus...
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Posted by admin on Apr 30, 2016 in |
In last few decades, there has been a great progress in understanding the biochemical and cellular events of normal wound healing. Healing of wounds, either accidental or surgical interventions, involves complex activities of blood cells, tissues, soluble mediators, cytokines and several growth factors. This increased cellular activity of damaged tissue enhances metabolic demands and active drug therapy. The main objective of treating a wound is to either shorten the time required for healing process or to minimize the undue effects. Plants due to presence of various valuable active phytoconstituents have immense potential for management and treatment of wounds over the years. All the Traditional systems of medicine, Ayurveda, Siddha and Unani describe applications of drugs of plant, mineral and animal origin to treat and heal wounds. Herbal drugs induce healing and regeneration of lost tissue by number of mechanisms. Due to their traditional applicability, affordability and safety plants gained a reputed position in the world of wound management and repair but scientific evidence for their wound healing potentials are...
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Posted by admin on Apr 30, 2016 in |
Recently the synthesis of fused heterocyclic compounds seeks great attention of researches in the field of medicinal chemistry. Majority of the drug compounds contains heterocyclic ring in their structures and these heterocyclic skeleton contributes significantly in the biological profile of drug. The heterocyclic compound play significant role in synthetic chemistry and many heterocyclic derivatives have been successfully synthesized as potent drug molecule. Many researchers have focused on the synthesis of fused heterocyclic compounds considering the beneficial property of fused derivatives and some of the fused heterocyclic compounds were found to possess potent biological action such as; antibacterial, antiallergic, anti-inflammatory, antitumor and antiparkinsonism etc. The basis of synthesizing fused heterocyclic derivatives resides in the fact that combination of two molecules or incorporation of new molecule in previously bio-active compound may potentiate action of each other synergistically, sometimes fusion leads formation of derivatives with newer biological profile other than the combining structure. This review article covers the most active heterocyclic compounds which possess considerable biological...
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Posted by admin on Apr 30, 2016 in |
Although plenty of information relating to drug utilization among adults is available, the literature pertaining to children is scarce. The majority of drugs prescribed have not been tested in children and safety and efficacy of children’s medicines are frequently supported by low quality of evidence. This is explained by the lack of clinical research in this population, caused by ethical, scientific and technical issues, besides commercial priorities. Therefore, most of the therapies prescribed to children are on an off-label or unlicensed basis. The off-label and unlicensed use of medicines is widespread and variable depending on the level of health care available, speciality concerned and patient characteristics. In the recent years, various laws and guidelines from the competent authorities have come up regulating the drug use and clinical research among children. This article reviews various pros and cons of the off-label use of medicines in children including various types, incidence rates, reasons, risks, consequences, management modalities, national and international guidelines related to the...
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Posted by admin on Apr 30, 2016 in |
The post approval changes are the changes made to biological products that have received an approval and to provide the data to support a change which would be considered sufficient to allow a determination of the impact of the change on the quality of the approved products as it relates to safety, efficacy and/or effective use of the products. After the approval of NDA or ANDA, the applicant may make post approval changes, provided the changes are reported to the FDA under the appropriate categories. Section 506 A of the Federal Food, Drugs and Cosmetics act and 21 CFR 314.70 provide for three reporting categories of the post approval changes namely: major change, moderate change and minor change. There are many reasons for making changes to pharmaceutical products after the original regulatory approval is obtained. Company change control procedures should detail how changes are evaluated and implemented as well as how the change impacts stability and what data will be needed to support the change. The regulatory group will...
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