Posted by admin on Sep 30, 2015 in |
The broad and potent activity of piperazine has established it as one of the biologically important scaffolds. This article is an effort to highlight the importance of the piperazine in the present context and promise they hold for the future. This review mainly focused the updated information on the most active piperazine derivatives that have been reported to show significant biological actions for instance anti-microbial, anti-depressant, anticonvulsant, anti-parkinson, anti-inflammatory, antipsychotic, antioxidant, antidiabetic, antiarrhythmic, antiproliferative, anxiolytic, antialzheimer, antimalarial, antihypertensive, antiplatelet aggression and anti-histaminic activity. This review would take on benzylpiperazine (BZP) and trifluoromethylpiperazine (TFMPP), benzhydryl piperazine, diphenylalkyl piperazine, phenyl piperazine as the most popular member of the piperazines, focusing the discussion on their origins, pharmacokinetics and pharmacodynamics, and their effects on the human body. From these outcomes, information for future molecular modifications leading to compounds with greater positive pharmacological properties may be...
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Posted by admin on Sep 30, 2015 in |
Pyrazoline, among the various 5-membered heterocyclic compound derivatives has drawn attention towards it because of its various pharmacologically activities associated with it. Pyrazolines are a five membered heterocyclic having two adjacent nitrogen atoms within the ring with only one endocyclic double bond and is basic in nature. A lot of research work has been done on synthesis and biological activities of various pyrazoline derivatives over the years. Pyrazolines derivatives display tremendous biological activities such as antimicrobial, anti-inflammatory, analgesic, antipyretic, antidepressant, antitubercular, antiamoebic, anthelmintic, anticonvulsant, antihypertensive, antidiabetic, antitumor, anti-HIV, local anaesthetic, antioxidant, insecticidal, tranquilizing and receptor selective biological activity. The history of pyrazoline shows that it attracted many chemists to explore pyrazoline as a biologically active molecule. The study of biological evaluation of pyrazoline derivatives has been an interesting field of pharmaceutical chemistry. This review article focuses on the pharmacological profile of pyrazoline with various activities and examples in form of...
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Posted by admin on Sep 30, 2015 in |
Globally cancer is a disease which severely effects the human population. There is a constant demand for new therapies to treat and prevent this life-threatening disease. Scientific and research interest is drawing its attention towards naturally-derived compounds as they are considered to have less toxic side effects compared to current treatments such as chemotherapy. The Plant Kingdom produces naturally occurring secondary metabolites which are being investigated for their anticancer activities leading to the development of new clinical drugs. With the success of these compounds that have been developed into staple drugs for cancer treatment new technologies are emerging to develop the area further. New technologies include nanoparticles for nano-medicines which aim to enhance anticancer activities of plant-derived drugs by controlling the release of the compound and investigating new methods for administration. This review discusses the demand for naturally-derived compounds from medicinal plants and their properties which make them targets for potential anticancer...
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Posted by admin on Sep 30, 2015 in |
Ethosomes are phospholipid-based elastic vesicles which have a potential as novel topical and transdermal drug delivery systems. They are ethanolic phospholipids vesicles which can act as carriers for various medicaments. Ethosomes have gained importance in the area of research, because of their intensified skin permeation, better delivery of drug and increased drug entrapment efficiency. These systems are more efficient in delivering substances to the skin because of the presence of ethanol, which provides a net negative charge on the surface, which helps to avoid aggregation of vesicles due to electrostatic repulsion than either conventional liposomes or hydroalcoholic solutions in terms of quantity and depth. Ethosomes are simple to prepare and safe to use. This review attempts to compile the various aspects like mechanism of action, methods of preparation (Hot method, Cold Method, Dispersion method using rotary evaporator) ,advantages, limitations, characterization, applications in different conditions like Anti-inflammatory, Arthritis, Acne, Fungal infections, Bronchial asthma, chronic bronchitis, emphysema, Diabetic condition, Scleroderma, systemic lupus erythematosus and psoriasis, etc of reported ethosomal formulations for...
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Posted by admin on Aug 31, 2015 in |
Resveratrol, an antioxidant found in red wine and certain foods, has been touted as a natural way to slow aging and fight cancer, obesity, heart disease, and diabetes. It also could be accounted as an agent, which has effects to reduced risk of inflammation and blood clotting. In addition there are some studies showing that resveratrol may actually reduce the positive effect of exercise on the heart in older men, but it’s important to know that its effects only last a short time after drinking red wine. As promising as it sounds, it is not yet established how resveratrol affects humans, since most studies have been conducted on animals and microbes. Because the information on resveratrol, presented in literature, pointing its health and adverse effects is full with contradictions, especially with respect to the human response, we tried to present the available information with minimal commentary, remaining as neutral as possible and allowing the reader to draw its own conclusion on recommendation of the wide increase usage of resveratrol...
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