Posted by admin on Jun 30, 2015 in |
In the recent years there is new development in field of colon specific drug delivery system. The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs. The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease, Crohn’s disease, ulcerative colitis, etc. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. It also plays vital role in systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs and anti-diabetic agents. This review article discusses introduction of colon, need and Primary approaches for CDDS (Colon Specific Drug Delivery), which includes prodrugs, pH and time dependent systems and microbially triggered drug delivery system. Newly developed CDDS, which includes pressure controlled colonic delivery capsules (PCDCS), CODE and osmotic controlled drug delivery and also focuses on evaluations of Colon targeted drug delivery in...
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Posted by admin on Jun 30, 2015 in |
The term Hydrotherapy refers to a process which uses water at any temperature or forms to relieve pain and treat illness. This review describes about various conditions of water treatments. Hydrotherapy may help treat various conditions, including arthritis, stomach issues, sleep disorders, stress and depression. The theory behind hydrotherapy is that water has healing properties that can relieve various ailments and conditions. In its different forms—ice, liquid, and steam—water is a versatile treatment method. Water cure therapies includes enema therapy, gel therapy etc, which includes colonic hydrotropy, sitz bath, hydro-massage, wraps and compress methods. Recently we have a number of hydrotherapy treatments available which includes personal infrared sauna rooms and peat bath rooms. These are useful in pregnancy, heart or lung conditions, diabetes, neuropathy, high fever, acute headache, surgical implants, seizure disorders etc. Cryotherapy, cold water immersion or ice bath is a new form of hydrotherapy used by physical therapists, sports medicine facilities and rehab...
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Posted by admin on Jun 30, 2015 in |
Impurity profiling is the process of evaluating data for the biological safety of an individual impurity. Impurity profiling has gained utmost importance due to the fact that unidentified impurities present in the pharmaceutical formulations may prove hazardous to human health on consumption. Impurities in pharmaceuticals are unwanted compounds that remain or those that are present during the formulation of drugs. A number of regulatory agencies like USFDA, ICH and Canadian Drug and Health Agency are emphasizing on the purity requirements as well as identification of impurities in active pharmaceutical ingredients. Impurity profiling, helps in the detection, identification, and quantification of various types of impurities present in pharmaceutical formulations. Identification of impurities can be done by using either chromatographic or spectroscopic techniques alone or by combination of both. A number of methods have been used for detecting and characterizing impurities using HPLC, HPTLC, AAS, TLC, etc. However the most exploited techniques used today for impurity profiling of drugs include LC-MS, GC-MS, NMR-MS, LC-MS-MS and LC-NMR. Therefore, this review focuses on...
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Posted by admin on Jun 30, 2015 in |
The complications as well as expense had been increased in marketing new chemical entities (NCEs) due to their poor solubility, high toxicity, high dosage, non-specific delivery, in-vivo degradation and short circulating half-lives. Nanoparticles possess immense prospective as an efficient drug delivery system. Nanoparticulate-based delivery systems have potential to significantly impact on pharmaceutical industry and can make a huge impact through drug targeting because it leads to reduction in toxicity and increased efficiency of chemical entity. Nanoparticulate drug delivery system has been extensively useful in the field of pharmaceutical, because they results in controlled and sustained release properties and can decrease the gap between drug discovery and drug delivery. This review aims to summarize various production methods, attributes, drug loading, drug release pattern and pharmaceutical applications of NPs. In this review, numerous potential methods employed for fabricating NPs such as emulsification solvent evaporation method, solvent diffusion method, salting out technique, coacervation/precipitation and polymerization has been illustrated through sequential...
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Posted by admin on Jun 30, 2015 in |
Pain is the most predominantly associated symptom with patients visit to the dental office. The pain may arise due to either an endodontic cause or a periodontic cause, but the endodontic pain type variant is the most commonly encountered by the dentists in their dental offices. Even though the endodontic pain is more common, there arises a dilemma in diagnosing and planning the treatment for the patient in day to day practice. This makes the proper diagnosis and adequate management of the endodontic pain as an important part of any dental practice. This article aims to review the importance of diagnosing the cause and adequate treatment for endodontic...
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