Posted by admin on Jan 30, 2015 in |
Osteoarthritis is a form of arthritis, and is the most common form of arthritis. Persons suffering from osteoarthritis have symptoms of pain, stiffness, decreased range of motion of affected joints. Although NSAIDS are the most commonly prescribed agents for this disorder but can cause of serious adverse effects. Two compounds Glucosamine and chondroitin which are extracted from animal products have been used in various forms for OA. To assess the clinical effectiveness of glucosamine and chondroitinsulphate in treatment of osteoarthritis symptoms like joint pain, joint space narrowing, reduced walking time, swelling etc. We searched articles separately for glucosamine and chondroitin sulphate using internet. Fifteen articles met the inclusion criteria. Data from articles was extracted using a standardized data extraction tables i.e. table1 and table 2. Glucosamine and Chondroitin sulphate are effective in the treatment of Osteoarthritis because these canreducepain, prevent further joint space narrowing and solve other related problems of this disease. The two agents can be used in osteoarthritis treatment as their safety is already assured as compared...
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Posted by admin on Jan 30, 2015 in |
The advent of nanotechnology lead to invention of many dosage forms. Effective targeted drug delivery systems have been a dream for a long time, due to several major drawbacks, a practical approach has been developed for the formation of discrete functionalized particles, which have been termed as ‘Nanosponge’. The development of new colloidal carrier called Nanosponges has the potential to solve these problems. Nanosponge is a novel and emerging technology it can precisely control the release rates of controlled drug delivery for topical use. The invention of Nanosponges has become a significant step toward overcoming these problems. Nanosponges are tiny sponges with a size of about a virus, which can be filled with a wide variety of drugs. These tiny sponges can circulate around the body until they encounter the specific target site and stick on the surface and begin to release the drug in a controlled and predictable manner. Because the drug can be released at the specific target site instead of circulating throughout the body it will...
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Posted by admin on Jan 30, 2015 in |
Diabetic nephropathy is a major complication of diabetes and the most common cause of end stage renal damage (E.S.R.D). Diabetic nephropathy is a leading cause of morbidity and mortality and its prevalence is continuously increasing in industrialized nations. Hyperglycemias, hyperlipidaemia and hypertension are considered to be the major risk factors implicated in the progression of nephropathy. Possible mediators of untoward effects of hyperglycemias include advanced placation end products (AGEs) known to accumulate in diabetic subjects. However, mechanisms underlying the pathogenesis of diabetic nephropathy are not completely understood. AGEs have been recently reported to play an important role in the pathogenesis of diabetic complications, particularly in the progression nephropathy. At present, no promising therapy is available to treat patients with diabetic nephroapthy due to lack of understanding of mechanism involved in the pathogenesis of nephropathy. There have been wide-ranging reports underline the involvement of AGEs in progression of the diabetic nephropathy, but the exact mechanism is not known clear yet, Therefore in these review are trying to explore the interactive...
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Posted by admin on Jan 30, 2015 in |
Nature is an eminent source of potential therapeutic drugs, however; most of the herbal bioactives are left unexploited as precise remedies due to lack of appropriate formulation design and development. Pharmacological interventions of herbal molecules may often be limited due to insufficient solubility, bioavailability as well as instability aspects and it remains one of the most challenging facet for pharmaceutical scientists worldwide. Solid dispersion is one of the well established and convenient techniques for improving the oral absorption of drugs with poor aqueous solubility and dissolution rate. The objective of present study is to enlighten the role of solid dispersion approach for enhancement of solubility and bioavailability profile of various natural moieties. The manuscript also aims to summarize the important features of solid dispersions, carriers utilized, classification, preparation methods and characterization parameters. Numerous and significant research findings in the vistas of phytoconstitutents based solid dispersions are also...
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Posted by admin on Jan 30, 2015 in |
The histamine H3 receptor is an G protein-coupled receptor that regulates neurotransmission in the central nervous system and plays a major role in cognitive and homeostatic functions. The third histamine receptor was discovered in 1983 by a traditional pharmacological approach, consisting of assessing the inhibitory effect of histamine on its own release from depolarized rat brain slices. Histamine H3 receptors are found mostly in central nervous system also to some extent in peripheral tissues and involved in the regulation of release of various neurotransmitters in brain. They have been implicated in diverse potential therapeutic applications such as sleep wake disorders, attention-deficient hyperactivity disorder, epilepsy, cognitive impairment and obesity. This review is aimed to provide an overview of marketed preparations and also experimental H3 receptor antagonists under pipeline of drug discovery and...
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