Posted by admin on Dec 25, 2014 in |
Today, Proliferation is being observed in neutraceutical industry due to health seeking consumer trend.Neutraceutical has evolved from health promoting to disease preventing supplements. Various herbs and their phytochemicals discussed in the present review can prove potent neutraceuticals as they are pharmacologically safe and provide advantages in terms of suppressing tumor progression, increasing the sensitivity of chemo- and radio- therapeutics, and alleviate the side effects of chemo- and radio-therapy.The review has been devoted towards better understanding of potential of these nutraceuticals as combinational therapy in cancer...
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Posted by admin on Dec 25, 2014 in |
Since 1982, Wnt1 (Wingless int-1) was first identified in mammary carcinoma. Further, Wnt signaling pathway was discovered. Wnt signals were involved in stem cells development, regeneration, cell cycle and repair mechanism. Finally abnormality Wnt signals were stimulated variety of cancers. Especially, non-canonical signaling pathways such as Wnt/PCP and Wnt/Ca2+ pathway were involved in development process. These pathways regulated stem cells and organ development such as cell polarity, adhesion, cell shape and cell movement. Despite, aberrant expression of non-canonical pathway induced tumorigenesis in development. In clinical studies, drugs were developed against cancer cells not in cancer stem cells. Drugs will synthesis against cancer stem cells based on the activation of abnormality of Wnt...
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Posted by admin on Dec 25, 2014 in |
Research in medicinal plants has gained a renewed focus recently. The prime reason is that other system of medicine although effective come with a number of side effects that often lead to serious complications. Plant based system of medicine being natural does not pose any serious problems. Although Emblica officinalis has a range of medicinal applications, but it is the need much period of time to explore. The use of Emblica officinalis as antioxidant, immune modulatory, antipyretic, analgesic, cytoprotective, anti ulser, immune modulatory, anti inflammatory, antitussive and gastroprotective are also studied. Emblica officinalis having a strong Memory enhancing property, in lowering cholesterol level, applicable in ophthalmic disorder, are reviewed. The effects of Emblica officinalis also take account as an antimicrobial action and in neutralizing snake venom are also...
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Posted by admin on Dec 25, 2014 in |
One of the biggest challenges faced by pharmaceutical scientists is poor solubility and bioavailability of new chemical entities (NCEs). According to BCS classification; approximately 25% of all compounds are classified as highly soluble and permeable. Nearly 40% of the new chemical entities currently being discovered are lipophilic so poorly water soluble drugs. BCS Class II and Class IV have low solubility. Aqueous solubility of any therapeutically active substance is a key property as it governs dissolution, absorption and thus the in -vivo efficacy. A surprisingly large proportion of new drug candidates emerging from drug discovery programs are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called ‘brickdust’ candidates can now be rescued by Nanonization. Formulating the poorly soluble compounds as pure drug nanoparticles is one of the newer drug-delivery strategies applied to this class of molecules. The present review deals in detail about the different techniques used for the improvement of the solubility and dissolution rate of poorly water soluble drugs with the use of...
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Posted by admin on Dec 25, 2014 in |
Developing innovative delivery strategies remains an ongoing task to improve bothefficacy and safety of drug-based therapy. Anti-cancer drug treatment is seriously affected by various undesirable properties such as poor solubility, narrow therapeutic index and efflux transporter specificity. One of the primary aspects of a successful cancer treatment regimen is to deliver sufficient amounts of drug to tumors while minimizing damage to normal tissues. In this review we highlight the development of promising recent innovative approaches that will hopefully offer not only gains in efficacy, but also in safety, tolerability and convenience in the treatment of patients with cancer. Drug delivery remains a challenge in management of cancer. Approximately 12.5 million new cases of cancer are being diagnosed worldwide each year and considerable research is in progress for drug discovery for cancer. Cancer drug delivery is no longer simply wrapping up cancer drugs in a new formulation for different routes of delivery. The focus is on targeted cancer therapy. The newer approaches to cancer treatment not only supplement the conventional...
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