Posted by admin on Dec 25, 2014 in |
Selaginella bryopteris (L.) Bak. usually known as “Sanjeevani’, is a lithophyte with remarkable resurrection capabilities and medicinal properties. It is traditionally used for curing wounds and irregular menstruation, uterine disorders and other internal injuries. It contains a variety of secondary metabolites such as alkaloids, phenol and terpenoids etc due to which it can act as antioxidants, anti-inflammatory, anti-cancer, anti-allergic, antimicrobial, antifungal, antibacterial, antiviral etc. It is also used as a strength tonic to improve fitness and to extend lifespan by the local tribal communities of India. The herbs are extensively exploited and sold throughout the country in different markets. There is an urgent need to aware the scientist, researchers, forest officials and local peoples about its medicinal properties, traditional knowledge, economic potential, endemic nature, horticultural and aesthetic value. Its distribution, medicinal and economic potential, taxonomy, ecology, causes of depletion and conservation strategies discussed in...
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Posted by admin on Dec 25, 2014 in |
Chitosan a natural polymer available and easy to produce in countless parts of the world; is a material that can significantly improve the standard of living in developing countries where the industry is often surpassing the need to protect the environment and/or where the environment protection is strongly dependent on limited financial resources available to those in charge of environmental protection. Its physicochemical properties such as its poor solubility in water or in organic solvents limit its utilization for a specific application. A smart way is to impart new properties to chitosan is its chemical modification of chain, generally by grafting of functional groups without disturbing the initial skeleton in order to keep the original properties intact. In this way the modified chitosan offers huge relevance in terms of its modified derivatives. The present review is dedicated to the advancements in the chitosan based derivatives and their special attention in food industry as the packaging material is also...
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Posted by admin on Dec 25, 2014 in |
Up till now, the most thriving and extensively used antineoplastic agent with well-established effectiveness is cisplatin. Being a non-specific drug, it reacts not only with genomic DNA but also binds and damages the plasma protein and cytoplasmic protein that confers to cisplatin resistance and severs side effects. DNA damage prompted by cisplatin leads to the activation of many signaling cascades that clue to cell death. This review work comprises interactive pathways of cisplatin with mitochondrial proteins such as p53, p38, p73 and c-Abl which contribute their role in cell death. In addition, disturbance in drug efflux and influx and competent role of repair protein also share in cisplatin resistance. Inhibition of Akt, MKPI, cabl stimulation, amplified activity of p53, p73, and MAPK, increased expression of pro apoptotics (Bax, Bck, Bcd) and decreased expression of anti apoptotic pointers to cisplatin sensitivity. Innovative creation or amendment in a platinum based drug which can magnify the numerous advantageous pathways and precisely constrains the various undesired pathways would greatly contribute to conquest against...
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Posted by admin on Dec 1, 2014 in |
Liquisolid Technique is one of the novel approach for drug delivery system for oral route. Bioavailability of any drug is mainly dependent upon its dissolution rate and dissolution rate is dependent upon solubility of that drug. So, if any drug has less solubility then of course its bioavailability will be less. Hence there is need of enhancement of solubility of poorly soluble drugs for enhancing their bioavailability. There are various methods which are used for enhancing bioavailability of poorly soluble drugs like micronization, nanonisation, supercritical fluid recrystallisation, spray freezing in to liquid, use of surfactants, use of salt forms, pH adjustment, solid dispersion, chemical modification, micellar solubilization.etc. Nowdays liquisolid technique is used as one of the method for enhancing solubility of poorly soluble drugs. Liquisolid technique is also called as ”Powdered Solution Technology” In this technique liquid drugs or drug suspensions or solutions of water insoluble solid drugs in suitable nonvolatile solvent system into non adherent, freely flowing, readily compressible powder by blending it using suitable carrier material and...
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Posted by admin on Dec 1, 2014 in |
To cure all aliments of mankind, nature provides a complete store house of remedies for time honored period.In legume family, Mimosa is one of the largest genera which distribute more than 500 species. This article aims to provide a comprehensive review on plant movement, chemical constituents, pharmacological activities and uses on Mimosa pudica, sensitive plant. Its habitat are lowland tropical rainforest, savanna, tropical and subtropical dry forest and thorn scrub, mid-elevation subtropical forest, desert, grassland, and wet land. It is a rich source of flavanoids, tannins, plant hormones, amino acids and glycosides. The innumerable medicinal properties and therapeutic uses of Mimosa pudica as well as its isolated active constituents prove its importance as a valuable medicinal...
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