Posted by admin on Sep 30, 2024 in |
Look-alike ampoules of tranexamic acid and local anaesthetic heavy bupivacaine are available, leading to accidental administration. We aimed to investigate India-specific incidents of intrathecal tranexamic acid (TXA) administration during spinal anaesthesia to identify manufacturing issues. Our secondary aim was to determine the availability of any national drug error reporting and monitoring system for hospitals in India. The author investigated published ten reports (11 patients) from India of TXA administration intrathecally in place of heavy bupivacaine. In all mistakes of look-like TXA and local anaesthetic (LA) (heavy 0.5% bupivacaine), ampoules were present in operating rooms. We found three manufacturers who designed, manufactured, and supplied identical TXA and heavy bupivacaine ampules. In addition, there was also a similarity of TXA and LA ampoules among different manufacturers. We searched PubMed and Google Scholar for any publication on India’s national medication error reporting system for hospitals. There was no publication on the national medication safety system involving hospitals. Our study shows intrathecal TXA errors occurred in east-to-west and north-to-south locations. However, there is...
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Posted by admin on Sep 30, 2024 in |
In this comprehensive review, the medicinal properties of Tulsi are thoroughly explored, highlighting its esteemed therapeutic uses that are widely regarded as safe, cost-effective and efficacious owing to its abundant availability. Tulsi a member of the genus Ocimum and a revered medicinal plant native to India has garnered significant recognition and reverence for its profound healing capabilities across generations. Its roots, leaves, and seeds boast a diverse array of medicinal properties, offering a broad spectrum of benefits to human health. Renowned for its anti-aging, immunomodulatory, antimicrobial, and anticancer properties, Tulsi has earned the esteemed title of the ‘Queen of Herbs’ in India symbolizing its paramount importance in traditional Ayurvedic and Unani medicinal practices. Characterized by its distinct square stem and aromatic essence, Tulsi holds a prominent place in Ayurvedic medicine with its extracts frequently utilized in remedies for ailments ranging from common colds and headaches to gastrointestinal disorders, cardiovascular ailments, poisoning, and even...
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Posted by admin on Sep 30, 2024 in |
Drug-delivery systems designed for specific targets allow drugs to be precisely delivered to areas affected by diseases. Various carriers are used to deliver drugs, including immunoglobulins, serum proteins, synthetic polymers, liposomes, niosomes and microspheres. In the last decade, there has been a considerable amount of interest directed towards the advancement of surfactant-based vesicles (known as Niosomes) for the purpose of improving drug delivery. Niosomes are self-assembled vesicular nanocarriers that are produced when cholesterol, non-ionic surfactant, or other amphiphilic compounds are hydrated & having a range of applications, including brain-targeted delivery and cutaneous delivery. Similarly to liposomes, niosomes can carry lipophilic and hydrophilic cargoes due to their bilayer structure. A vast number of research articles have been published on their manufacturing methods and applications in pharmaceuticals and cosmetics. Furthermore, niosomes may be created using simple procedures, need lower production costs, and are viable for extended periods of time, thus eliminating the fundamental limitations of liposomes. This review provides an overview of the present status of niosomal research, including the development...
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Posted by admin on Sep 30, 2024 in |
The review paper comprehensively explores the immunomodulatory potential of Bauhinia variegata flower extract, a traditional medicinal plant renowned for its therapeutic properties. With a focus on its rich history in traditional medicine systems and its diverse pharmacological activities, the paper delves into the botanical and chemical composition of the extract, highlighting key bioactive compounds such as flavonoids, alkaloids, tannins, and phenolic compounds. It meticulously outlines the morphological characteristics of Bauhinia variegata flowers and its traditional medicinal uses, shedding light on its significant role in treating various health ailments. Moreover, the paper meticulously examines the intricate mechanisms underlying the extract’s immunomodulatory effects, including modulation of cytokines, activation of immune cells, antioxidant activity, and regulation of immune signaling pathways. Through in-vitro, in-vivo, and ex-vivo studies, the extract’s ability to enhance immune responses, alleviate inflammation, and mitigate immune-related disorders is thoroughly elucidated. Furthermore, the review offers a glimpse into future perspectives, advocating for continued research to identify specific bioactive compounds, elucidate underlying mechanisms of action, explore synergistic interactions with other drugs, and...
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Posted by admin on Sep 30, 2024 in |
Thrombocytosis is defined as platelet count greater than 400, 000/mm3. Thrombocytosis can be either primary or secondary. Meropenem is a parenteral carbapenem antibiotic that has great bactericidal activity against almost all significant aerobes and anaerobes. Common adverse effects such as pain at the injection site, skin rash, transitory metabolic disorders such as increased liver enzyme levels, increased creatinine blood levels, or increased urea levels, or hematological disorders (thrombocytosis, eosinophilia) may be observed. Thrombocytosis due to Meropenem is relatively rare and here we report one such case of Meropenem induced thrombocytosis in a 26-year-old patient post cesarean delivery. A 26-year-old primigravida with 38 weeks gestation presented in labour for four hours. Her investigations revealed hemoglobin of 10.3, deranged LFT and thrombocytopenia. A provisional diagnosis of primigravida with 38 weeks gestation with Fetal Growth Restrictionwith jaundice, thrombocytopenia (TTP) in latent phase of labour was made. Later, the patient was taken up for emergency caesarean in view of fetal distress. Postoperatively the patient was given injectable ceftriaxone and metronidazole. Patient developed high grade fever (101 -103 F) on day 4 for...
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