Posted by admin on Feb 26, 2015 in |
Population control is a significant issue worldwide especially in developing countries like India. Population breakout has responsible for various deleterious effects on life surviving resources on the earth. Therefore fertility regulation is necessary for the conservation of life supporting resources as well as good reproductive life of both males and females. Various chemical methods of contraception are available today but these methods possess several side effects. Herbal medicinal plants have been used as safe alternatives of the chemical methods. Evaluation of the herbal medicinal plants has been in progress for several decades to identify effective and safe substances for fertility regulation. Several medicinal plant extract were investigated for their antifertility activity both in male and female animal models. This review covered scientific proven information on various medicinal plants used for antifertility activity in both males and females. This review provides information on botanical name along with their common name, antifertility activity, part used and their phytochemicals present in...
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Posted by admin on Feb 26, 2015 in |
Synthesis of heterocylic compound has always drawn the attention of chemist over the years mainly because of their important biological properties. Particularly, the role of β–lactam which are endowed with unique structure and potent biological activity. The β-lactam heterocycles are considered as an important contribution of science to humanity since they have been constituents of living organisms, natural products, drugs and many more substances useful to mankind and society in all walks of life. Their synthesis and evaluation has always drawn the attention of biologists over the years. β-lactam, a four member heterocyclic compound involved in research aimed to evaluate new products that possess interesting biological activities. Natural and synthetic β-lactam derivatives occupy a central place among medicinally important compounds due to their diverse and interesting antibiotic activities and are still the most prescribed antibiotics used in medicine. The present review article focuses on the pharmacological profile of β-lactam with their potential activities. The ring system exhibits a wide range of activities like antimicrobial, antitubercular, anticancer, antidiabetic, tryptase and...
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Posted by admin on Feb 26, 2015 in |
Lovastatin is a naturally occurring drug of statin family used for lowering cholesterol. It is found that it can be useful for treatment or management of multiple diseases and has immense medicinal significance. On one side, this drug is used to induce apoptosis in various cancer cells, while other reports indicate that it also promotes cell survival to alleviate certain disease conditions. Antiviral role of lovastatin has also been reported. So, lovastatin, if recommended for any therapy, first requires thorough study as well as experimentations both in-vitro and in-vivo. Current review is systematic, based on search from PubMed by entering key words “Lovastatin cancer, Lovastatin apoptosis and Lovastatin survival” with filter for seven years (2008-2014) data only. It is concluded from the study that Lovastatin has multidirectional role and may be helpful in cancer cells apoptosis as well as survival of certain types of cells. It may be used as anti-viral agent...
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Posted by admin on Feb 26, 2015 in |
A budding interest in Nanopharmaceuticals had generated a number of advancements throughout recent years with a focus on engineering novel applications. Nanophytomedicines are prepared from active phytoconstituents or standardized extracts. The world market for nanomedicine is estimated to reach $130.9 billion by the fiscal year 2016. Liposome nanoparticle (NP) with entrapped doxorubicin was reported by researchers to be 300 times more effective because of better pharmacokinetic ability in treatment of Kaposi sarcoma. Nanotized herbal drug containing active principles of seawort, cassia twig and liquorice root was found to be effective in pulmonary, liver, bone and skin cancer. Nanotechnology also offers the ability to detect diseases at much earlier stages, such as finding hidden or overt metastatic colonies often seen in patients diagnosed with breast, lung, colon, prostate, and ovarian cancer. However, the safety and long-term effects of nanoformulations must not be overlooked. This review will provide a brief discussion of the major nanopharmaceutical formulations as well as the impact of nanotechnology on herbal drugs in...
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Posted by admin on Feb 26, 2015 in |
Over the past few decades the nasal route has gained widespread interest as a promising and an alternative route to oral and parenteral drug delivery. The nasal mucosa being highly vascularized and permeable provides a rapid onset of therapeutic action. It is a convenient, compliant and needleless mode of drug delivery suitable for the treatment of both acute and chronic diseases. In addition, nasal drug delivery circumvents the issues of poor and slow absorption, first pass hepatic metabolism, blood brain barrier. Intranasal administration can be used to deliver small polar molecules, hormones, vaccines, proteins and peptides. Despite the several potential advantages the nasal route has certain limitations. The present review outlines the various merits and demerits of intranasal administration, the relevant anatomy and physiology of the nasal cavity. The present article gives a detailed description of the factors affecting drug absorption and the different strategies that can be used to improve the drug...
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