Posted by admin on Dec 25, 2014 in |
Research in medicinal plants has gained a renewed focus recently. The prime reason is that other system of medicine although effective come with a number of side effects that often lead to serious complications. Plant based system of medicine being natural does not pose any serious problems. Although Emblica officinalis has a range of medicinal applications, but it is the need much period of time to explore. The use of Emblica officinalis as antioxidant, immune modulatory, antipyretic, analgesic, cytoprotective, anti ulser, immune modulatory, anti inflammatory, antitussive and gastroprotective are also studied. Emblica officinalis having a strong Memory enhancing property, in lowering cholesterol level, applicable in ophthalmic disorder, are reviewed. The effects of Emblica officinalis also take account as an antimicrobial action and in neutralizing snake venom are also...
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Posted by admin on Dec 25, 2014 in |
One of the biggest challenges faced by pharmaceutical scientists is poor solubility and bioavailability of new chemical entities (NCEs). According to BCS classification; approximately 25% of all compounds are classified as highly soluble and permeable. Nearly 40% of the new chemical entities currently being discovered are lipophilic so poorly water soluble drugs. BCS Class II and Class IV have low solubility. Aqueous solubility of any therapeutically active substance is a key property as it governs dissolution, absorption and thus the in -vivo efficacy. A surprisingly large proportion of new drug candidates emerging from drug discovery programs are water insoluble, and therefore poorly bioavailable, leading to abandoned development efforts. These so-called ‘brickdust’ candidates can now be rescued by Nanonization. Formulating the poorly soluble compounds as pure drug nanoparticles is one of the newer drug-delivery strategies applied to this class of molecules. The present review deals in detail about the different techniques used for the improvement of the solubility and dissolution rate of poorly water soluble drugs with the use of...
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Posted by admin on Dec 25, 2014 in |
Developing innovative delivery strategies remains an ongoing task to improve bothefficacy and safety of drug-based therapy. Anti-cancer drug treatment is seriously affected by various undesirable properties such as poor solubility, narrow therapeutic index and efflux transporter specificity. One of the primary aspects of a successful cancer treatment regimen is to deliver sufficient amounts of drug to tumors while minimizing damage to normal tissues. In this review we highlight the development of promising recent innovative approaches that will hopefully offer not only gains in efficacy, but also in safety, tolerability and convenience in the treatment of patients with cancer. Drug delivery remains a challenge in management of cancer. Approximately 12.5 million new cases of cancer are being diagnosed worldwide each year and considerable research is in progress for drug discovery for cancer. Cancer drug delivery is no longer simply wrapping up cancer drugs in a new formulation for different routes of delivery. The focus is on targeted cancer therapy. The newer approaches to cancer treatment not only supplement the conventional...
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Posted by admin on Dec 25, 2014 in |
Selaginella bryopteris (L.) Bak. usually known as “Sanjeevani’, is a lithophyte with remarkable resurrection capabilities and medicinal properties. It is traditionally used for curing wounds and irregular menstruation, uterine disorders and other internal injuries. It contains a variety of secondary metabolites such as alkaloids, phenol and terpenoids etc due to which it can act as antioxidants, anti-inflammatory, anti-cancer, anti-allergic, antimicrobial, antifungal, antibacterial, antiviral etc. It is also used as a strength tonic to improve fitness and to extend lifespan by the local tribal communities of India. The herbs are extensively exploited and sold throughout the country in different markets. There is an urgent need to aware the scientist, researchers, forest officials and local peoples about its medicinal properties, traditional knowledge, economic potential, endemic nature, horticultural and aesthetic value. Its distribution, medicinal and economic potential, taxonomy, ecology, causes of depletion and conservation strategies discussed in...
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Posted by admin on Dec 25, 2014 in |
Chitosan a natural polymer available and easy to produce in countless parts of the world; is a material that can significantly improve the standard of living in developing countries where the industry is often surpassing the need to protect the environment and/or where the environment protection is strongly dependent on limited financial resources available to those in charge of environmental protection. Its physicochemical properties such as its poor solubility in water or in organic solvents limit its utilization for a specific application. A smart way is to impart new properties to chitosan is its chemical modification of chain, generally by grafting of functional groups without disturbing the initial skeleton in order to keep the original properties intact. In this way the modified chitosan offers huge relevance in terms of its modified derivatives. The present review is dedicated to the advancements in the chitosan based derivatives and their special attention in food industry as the packaging material is also...
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