Posted by admin on Dec 25, 2014 in |
Up till now, the most thriving and extensively used antineoplastic agent with well-established effectiveness is cisplatin. Being a non-specific drug, it reacts not only with genomic DNA but also binds and damages the plasma protein and cytoplasmic protein that confers to cisplatin resistance and severs side effects. DNA damage prompted by cisplatin leads to the activation of many signaling cascades that clue to cell death. This review work comprises interactive pathways of cisplatin with mitochondrial proteins such as p53, p38, p73 and c-Abl which contribute their role in cell death. In addition, disturbance in drug efflux and influx and competent role of repair protein also share in cisplatin resistance. Inhibition of Akt, MKPI, cabl stimulation, amplified activity of p53, p73, and MAPK, increased expression of pro apoptotics (Bax, Bck, Bcd) and decreased expression of anti apoptotic pointers to cisplatin sensitivity. Innovative creation or amendment in a platinum based drug which can magnify the numerous advantageous pathways and precisely constrains the various undesired pathways would greatly contribute to conquest against...
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Posted by admin on Dec 1, 2014 in |
Liquisolid Technique is one of the novel approach for drug delivery system for oral route. Bioavailability of any drug is mainly dependent upon its dissolution rate and dissolution rate is dependent upon solubility of that drug. So, if any drug has less solubility then of course its bioavailability will be less. Hence there is need of enhancement of solubility of poorly soluble drugs for enhancing their bioavailability. There are various methods which are used for enhancing bioavailability of poorly soluble drugs like micronization, nanonisation, supercritical fluid recrystallisation, spray freezing in to liquid, use of surfactants, use of salt forms, pH adjustment, solid dispersion, chemical modification, micellar solubilization.etc. Nowdays liquisolid technique is used as one of the method for enhancing solubility of poorly soluble drugs. Liquisolid technique is also called as ”Powdered Solution Technology” In this technique liquid drugs or drug suspensions or solutions of water insoluble solid drugs in suitable nonvolatile solvent system into non adherent, freely flowing, readily compressible powder by blending it using suitable carrier material and...
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Posted by admin on Dec 1, 2014 in |
To cure all aliments of mankind, nature provides a complete store house of remedies for time honored period.In legume family, Mimosa is one of the largest genera which distribute more than 500 species. This article aims to provide a comprehensive review on plant movement, chemical constituents, pharmacological activities and uses on Mimosa pudica, sensitive plant. Its habitat are lowland tropical rainforest, savanna, tropical and subtropical dry forest and thorn scrub, mid-elevation subtropical forest, desert, grassland, and wet land. It is a rich source of flavanoids, tannins, plant hormones, amino acids and glycosides. The innumerable medicinal properties and therapeutic uses of Mimosa pudica as well as its isolated active constituents prove its importance as a valuable medicinal...
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Posted by admin on Dec 1, 2014 in |
Fluoroquinoloes are a very important group of antibacterial agents that are widely prescribed for the treatment of infectious diseases in humans. These agents have excellent bioavailability and good tissue penetration with antimicrobial activity against pathogens especially resistance to other class of antimicrobial drugs. This article gives a comprehensive review on different aspects of fluoroquinolones such as discovery, structural modifications, pharmacokinetic properties, antibacterial activity, present status of important drugs in which pharmacists and medical microbiologists should be interested....
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Posted by admin on Dec 1, 2014 in |
The management of eye disorders by chemical drugs without any side effects is still a challenge to the medical system. But the herbal medicines have potential to overcome the limitations associated with conventional drugs. Therefore; many efforts have been made to identify new medicinal plants from different sources because of their effectiveness, fewer side effects and relatively low cost. Approximately 200 plants worldwide have been documented to support treatment of eye disorders and several plant species have been advocated in Traditional Indian Medicine for their ophthalmic effects. In the present review it is proposed to highlight the medicinal plants used from ancient time for the treatment of eye diseases, their merits and demerits and role of Modern medicines over demerits of medicinal plants traditionally used for eye disorders. Review concluded that by using techniques and polymers of modern era, the best Ayurvedic formulations may be...
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