Posted by admin on Mar 1, 2014 in |
Hepatic diseases (Liver diseases) are a major worldwide health problem, with high endemicity in developing countries. Hepatic disease is a term for a collection of conditions, diseases, and infections that affect the cells, tissues structures, or functions of the liver. Liver has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for digestion and synthesis as well as breakdown of small and complex molecules, many of which are necessary for normal vital functions. There are no specific allopathic medicines used as hepatoprotective, although different research works are going on some drug. Herbal drugs are more widely used than allopathic drugs as hepatoprotectives because they are inexpensive, have better cultural acceptability, better compatibility with the human body and minimal side effects. The present review discusses different types of recently herbal plants containing hepatoprotective...
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Posted by admin on Mar 1, 2014 in |
Asparagus racemosus, a climbing Ayurvedic plant, is known for its numerous activities such as hyperlipidemia, hypertension, angina, dysmenorrhea, anxiety disorders, benign prostatic hyperplasia (BPH), leucorrhoea and urinary tract infections. This plant possesses a wide range of secondary metabolites inclusive of steroids, alkaloids, dihydrophenanthrene derivatives, flavonoids, furan derivatives and essential oils. Information from the literature suggests that, the major constituents of A. racemosus are steroidal saponins which are mainly responsible for different biological activities of A. racemosus. The review summarizes the information concerning the cultivation, morphology, phytochemistry, biological activities, safety profile, marketing status and conservation techniques of A....
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Posted by admin on Mar 1, 2014 in |
Exploration of biological diversity for identification of novel bioactive molecules or therapeutically more potential than the marketed products is a continuous ongoing process for drug development research. Indian traditional therapies have been a part of our lifestyle since ages. Due to their knowing ability and applications, this knowledge has long been used as thriving sources for discovery of new drug molecules. Historical text or traditional knowledge including folklore, ethnobotany or ethnopharmacological studies are proving to be a powerful tool for searching lead molecules for the development of new drugs. This review article presents the contribution on 33 medicinal plants along with their traditional uses, bioactive constituents, biological activities, chemical structures, and 30 marketed drug formulations at national and international markets. A brief note on the recent discovery on osteogenic compounds from Ulmus wallichiana, folk traditional plant used for healing fractured bones in Uttarakhand Himalaya is also discussed in this...
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Posted by admin on Mar 1, 2014 in |
Diabetes is a growing health concern worldwide and now emerging as an epidemic world over. The management of diabetes is still a major challenge. Plants have always been a source of drugs for humans since time immemorial. The Indian traditional system of medicine is replete with the use of plants for the management of diabetic conditions. According to the World Health Organization (WHO), up to 90% of population in developing countries use plants and its products as traditional medicine for primary health care. There are about 800 plants which have been reported to show anti-diabetic potential. Thus there is great demand for research on natural products with anti-diabetic properties. Numerous studies have confirmed the benefits of medicinal plants with anti-hyper-glycaemic effects in the management of diabetes mellitus. The present paper is an attempt to list of the plants with anti-diabetic and related beneficial effects originating from different parts of world. History showed that medicinal plants have been used in traditional healing around the world for a long time to...
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Posted by admin on Mar 1, 2014 in |
Human papillomavirus is one of the most common causes of sexually transmitted disease in both men and women worldwide. Genital HPV types are divided into high and low-risk types, on the basis of oncogenic gene potential. Molecular & epidemiologic studies have confirmed the interaction between high risk HPV types (especially HPV-16 & 18) and cervical squamous cell low risk strain. In high grade Intra epithelial neoplasias & invasive cancers, generally integration of HPV-DNA into the host genome disrupts or deletes the E2 region, which results in loss of its expression. The E6 and E7 gene deregulate the host cell growth cycle by binding and inactivating two tumor suppressor proteins: the tumor suppressor protein (p53) and retinoblastoma gene (pRb). The HPV E6 gene binds to p53 and targets it for rapid degradation leads to an increased expression of E6 and E7 genes. The inactivations of p53 & pRb proteins can increased proliferation rate & genomic instability. In addition, the potential of activated oncogenes cause chromosome instability may transformed in the...
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