Posted by admin on Sep 30, 2024 in |
Apart from the API, the excipient plays a crucial role in a formulation because of their versatile application, which enhances different physical and chemical characteristics in a dosage form. At present scenario natural polymers are considered a leading constituent as an excipient to formulate several innovative approaches for designing the drug delivery system. The components which are obtained from nature is always preferred for our health due to their fewer side effects. Hence, biopolymers have the additional privilege of being incorporated as an excipient in pharmaceutical formulations. Demand for natural polymers is enhancing day by day (increased 7.1% in every year as per scientific data) because of their versatile application in drug delivery systems and multiple utilization of several domains in the biomedical section. Low toxicity, compatibility, sustainability, biodegradability, swelling index, release pattern are the major Parameters of the biopolymers which alter the different pharmacokinetic and pharmacodynamic characteristics of a pharmaceutical dosage form. The major aim of this current review is to impart some knowledge related to the widespread...
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Posted by admin on Sep 30, 2024 in |
A developing class of medications called biosimilars is created to be used interchangeably with biologics. In living cells, biologics are often large, complicated proteins with a range of potential applications. Biologics are utilised to treat malignancies, endocrine problems, and inflammatory bowel diseases just within the discipline of gastroenterology. Despite the fact that many diseases can be effectively treated or managed with biologics, patient access is frequently constrained by their high cost. The creation of biosimilars is an effort to lower the cost of medical care. In terms of efficacy, side effect risk profile, and immunogenicity, biosimilars must be essentially equivalent to their reference biologics. Biosimilars go through fewer clinical trials than their reference biologics, despite the manufacturing process still requiring manufacture within living cells. As a result, the biosimilar medication is less expensive to produce and purchase than the reference biologic. Seven biosimilars have currently received FDA approval for use in the treatment of Crohn’s disease, ulcerative colitis, and colorectal cancer. There are further biologics used to treat gastroenterological...
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Posted by admin on Sep 30, 2024 in |
The development of effective therapeutic strategies for various remedial conditions often involves the exploration of synergistic interaction between two pharmacophores. The most frequent methods for multidrug therapy combining two or more active ingredients into a single, and creating hybrid molecular entities that can modulate numerous targets interaction gives a synergistic effect. As a result, the structural activity relationship is becoming more and more common in the form of hybrid molecules (multiple ligand approach) such as chalcone-isatin, ferrocene-isatin as well as ferrocene-chalcone combinations possesses multiple biological properties such as antitubercular, anticancer, antibacterial, Antimalarial, anti-inflammatory which having synergistic activity due to their combination as well as their substitutions like electron donating and withdrawing group. The evaluation of synergistic drug combinations offers promise in overcoming challenges such as drug resistance, dose-dependent toxicity, and suboptimal treatment responses. To determine the significance of the notion of molecular hybridization, the pharmacological potency of the hybrid molecules is compared to those of their separate counterparts. This review underscores the promising role of chalcone-isatin, ferrocene-isatin and ferrocene-chalcone...
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Posted by admin on Aug 31, 2024 in |
3D printing (a.k.a. fast prototyping or advanced manufacturing process) is estimated to be a highly innovative technology within the healthcare devices industry and pharmaceutical industry. With the use of digitally controlled material deposition straight from a computer-aided design, 3D printing technology can create 3D pharmaceutical items layer by layer. It facilitates the making of dosage forms such as composite products, personalized products, and products made on demand. Pharmacogenetic and pharmacokinetic features, age, weight, comorbidities, and other factors all influence the special needs of each patient, and three-dimensional (3D) printed medications have the potential to revolutionize the pharmaceutical business by providing individualized therapies. These supports provide the choice to alter the drug’s efficacy and safety. The capacity to manufacture very little of drugs with customized doses, forms, sizes, and release properties is the primary benefit of 3D printing technology. This method of producing drugs might make the idea of customized medications a reality for bettering patient care. Diverse three-dimensional printing methods have been developed to create innovative solids dosage forms....
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Posted by admin on Aug 31, 2024 in |
Herbal medicines, with their rich history of use, often face challenges in achieving optimal effectiveness due to low absorption rates and limited bioavailability of their phytoconstituents. While these constituents are typically water-soluble, their inability to penetrate lipid membranes compromises their efficacy. To overcome these limitations, integrating herbal drugs with nanotechnology has emerged as a promising approach. Nanoparticles offer a potential solution by enhancing the absorption, permeability, and retention of herbal extracts within the body. This augmentation can lead to improved potency while minimizing the required dosage and reducing side effects. Importantly, the utilization of nanotechnology does not disrupt normal physiological processes. The primary objective of this study is to systematically explore the application of nanotechnology in crafting herbal nano formulations aimed at various pharmacological activities. Through this investigation, we aim to elucidate how nanoparticles can synergize with herbal extracts to unlock their full therapeutic potential, paving the way for enhanced herbal medicine utilization in modern healthcare...
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