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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

IJPSR is indexed with Embase

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Posted by on Feb 1, 2014 in | 0 comments

APPROACHES AND SIGNIFICANCE OF TRANSDERMAL DRUG DELIVERY SYSTEMS: A REVIEW

Transdermal Drug Delivery System (TDDS) is the most innovative and Novel drug delivery systems by penetrating through the skin by increasing the scope of molecules that can be delivered.  TDDS that traditionally uses a patch containing loaded drug substances pressed on to the skin is convenient, painless and non-invasive, to avoid gastro intestinal (GI) tract toxicity (peptic ulcer disease). Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into systemic circulation which often causes undesirable side effect. The number of medications and the ways in which they can be administered have expanded dramatically over the years. One such advancement is the development of transdermal patch delivery systems. Transdermal drug technology specialists are continuing to search for new methods that can effectively and painlessly deliver larger molecules in therapeutic quantities to overcome the difficulties associated with the oral route. Various products of TDDS are in use by applying approaches like micro needles, abrasion,...

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AN UPDATE ON AYURVEDIC HERB HENNA (LAWSONIA INERMIS L.): A REVIEW

Lawsonia inermis L. is a much branched glabrous shrub or small tree, cultured for its leaves although stem bark, roots, flowers and seeds have also been used in traditional medicine. It has been traditionally reported in use of headache, hemicranias, lumbago, bronchitis, boils, ophthalmia, syphilitis, sores, amenorrhea, scabies, diseases of the spleen, dysuria, bleeding disorder, skin diseases, diuretic, antibacterial, antifungal, anti-amoebiasis, astringent, anti-hemorrhagic, hypotensive and sedative effect. The plant is reported to contain Lawsone, Esculetin, Fraxetin, Isoplumbagin, Scopoletin, Betulin, Betulinic acid, Hennadiol, Lupeol, Lacoumarin, Laxanthone, Flavone glycosides, two pentacytic triterpenes. The plant is reported to contain carbohydrates, proteins, flavonoids, tannins and phenolic compounds, alkaloids, terpenoids, quinones, coumarins, xanthones and fatty acids. The plant has been reported to have analgesic, hypoglycemic, hepatoprotective, immunostimulant, anti-inflammatory, antibacterial, antimicrobial, antifungal, antiviral, antiparasitic, antitrypanosomal, antidermatophytic, antioxidant, antifertility, tuberculostatic and anticancer properties. It is now measured as a valuable source of exclusive natural products for growth of medicines against various diseases and also for the development of industrial products. This review gives a bird’s eye...

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PROTEASOME INHIBITORS FOR USE IN MULTIPLE MYELOMA

The approval of first-in-class proteasome inhibitor bortezomib in 2003, made possible the therapeutic validation of proteasome as a target for use in discovery and development of new treatment options in cancer, particularly haematological conditions like Multiple Myeloma. However, this breakthrough drug discovery suffered from a few limitations. As a result, the discovery of bortezomib not only introduced to the pharmaceutical research community a new area but alsoprovided the impetus to work for a better future. The result was the recent approval of carfilzomib for use in relapsed and refractory multiple myeloma which revived the lagging area again and brought an upsurge in the area of research and development for second generation proteasome inhibitors directed towards this therapy. Here, we present a review on these second generation proteasome inhibitors currently in clinical or preclinical phase and try to assess the future for multiple myeloma...

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A REVIEW ON: POTENTIAL ANTIDIABETIC HERBAL MEDICINES

Diabetes mellitus (DM) is a metabolic disorder of the endocrine system. This frightful disease is found in all parts of the world and is becoming a serious threat to healthcare providers. Nowadays DM is a most spreading disease in the world. In rapidly growing world a number of treatment options are available for treatment of DM. Long term use of allopathic medicinal agents may cause unwanted side effects, resulting uncontrolled blood sugar as well as complications of DM, also DM is highly prone to different types of microorganism and it will affect immune system of body. The use of herbal medicine for the prevention and treatment of DM has been in practice since ancient time. Medicinal plants as a traditional medicine is being used by about 60% of the world’s population and India is major contributor to produced herbal medicines. Generally it is believed that the risk associated with herbal medicine is very less, but reports on serious reactions of herbal drugs are also necessary. Numerous herbal plants have...

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Posted by on Jan 14, 2014 in | 0 comments

SOME DRUGS IN ACTION: METAL IONS DO INFLUENCE THE ACTIVITY!

A large no of synthetic and natural compounds behave as very effective drugs. All these compounds have a wide range of biological activities like anti-bacterial, anti-fungal, anti-cancer, anti-viral, anti-inflammatory, anti-neoplastic, anti-tumorigenic, anti-HIV and so on. On the other hand, metals have played an important role in medicine for years. Many are essential in our diets in varying quantities. In addition to the metalloantibiotics, a number of drugs and potential pharmaceutical agents also contain metal-binding or metal-recognition sites, which can bind or interact with metal ions and potentially influence (increase or decrease) their bioactivities. In this review changes in drug potentiality upon interaction of metal ions with some natural and synthetic drugs have been discussed. Different metal ions which are toxic at higher concentrations are also useful for maintaining life processes at lower concentrations and are even effective in the modification of some well established drug molecules towards their better action. The alkaline earths and transition metal ions are the most thoroughly studied amongst...

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