Posted by admin on Aug 31, 2024 in |
In the pharmaceutical industry, combinatorial chemistry has emerged as a novel approach, facilitating the synthesis of multiple compounds simultaneously rather than focusing on individual compound. The quick production of the chemical means that this technology reduces the time and expense involved in drug research. In this review article, the topic of combinatorial chemistry is discussed in general terms, along with the concepts of combinatorial libraries, methodologies and applications. This technique significantly lowering the cost involved in new drug research and increases the chances of finding new lead molecules. Most commonly used combinatorial techniques are solid phase synthesis, Parallel synthesis, mixed combinatorial synthesis and solution phase synthesis. Combinatorial chemistry is useful for the efficient detection of big molecules as well as the production of tiny molecules and peptides. The aim of this project is to give a fundamental overview of combinatorial chemistry, outlining the evolution of key methods and a few...
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Posted by admin on Aug 31, 2024 in |
An overview of the drug discovery and development process in brief helps scientists whose work could be important in deciding the process to properly design their research report for the successful translation of preclinical research to human subjects. The idea for the drug’s discovery and development may have come from a variety of sources, including the demands of the market at the time, clinical and scholarly research, the commercial environment, etc. In order to control the marketing of drugs, each pharmaceutical industry is required to abide by the laws, rules, and regulations of their respective nation. The majority of newly developed medications on the market today are synthetic. The process of developing new medications is expensive due to the significant expenses linked to research and development as well as clinical trials. Information regarding drugs, the development process, and regulating bodies in Europe, Japan, the USA, and India are provided in this...
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Posted by admin on Aug 31, 2024 in |
Dineśavallīor Vēṁpātais a very popular Ᾱyurvēda herb used in South India for skin related ailments. In Kerala it is used in different formulations either as single drug or in combinations. There are no direct references to dineśavallī or Vēṁpāta in any bŗhatrayī or laghutrayī. From the previous studies it is confirmed that dineśavalli of south India is equated with ‘Ratanjot’– a herbal dye of North India and from the literature review, roots of Arnebia and Alkanna which is sold as ‘Ratanjot’. Dineshavalli (Vēṁpāta) is assumed to be sourced from Ventilago madraspatana Gaertn. belonging to Rhamnaceae family. But some allied species such as Ventilago bombaiensis Dalzell. and Ventilago denticulata Willd. are also termed as Vēṁpāta locally. Present study reviews the major classical texts of Ayurveda and peer reviewed articles to reveal the botanical identity, chemical constituents, pharmacological properties and its therapeutic efficacy of Dineśavallī or Vēṁpāta for the better...
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Posted by admin on Aug 31, 2024 in |
Metabolic syndrome is the most widely and prevailing health concern globally. It is a cluster of biochemical and physiological abnormalities that involve obesity, insulin resistance, dyslipidemia, and hypertension. Several studies have reported that the prevalence of the overall metabolic syndrome rate in adults is about 25% (approx. 31% in women and 18.5% in men) in India. Whereas the global prevalence is about 20-25% in 2020. The direct relationship between diet and health leads to various scientific studies to find the significant relation and their specific beneficial functions. Certain foods are thought to have physiological effects in the management of metabolic syndrome by assisting the body’s hemostasis mechanism. The present paper reviews different features of nutraceuticals and functional foods and their influence on the management of metabolic syndrome. Also, it overviews numerous functional ingredients in different food sources and their possible health...
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Posted by admin on Aug 31, 2024 in |
The primary cause of death for women with gynaecological cancer diagnoses is ovarian cancer. It is also, generally speaking, the sixth most common cause of death for women. The majority of cases had advanced diagnoses, which worsens the disease’s prognosis. The limited predictive value of the current screening tests adds even more suffering to the situation. The most important early detection techniques, which have not had a discernible positive impact on the morbidity or death of this malignancy, are comprehensive gynaecological evaluation, transvaginal ultrasonography, and laboratory markers such as the cancer antigen-125 (CA-125) assay. However, anti-angiogenic bevacizumab and Poly (ADP-ribose) polymerase (PARP) inhibitors have gained pace in the management of this condition. Traditionally, the treatment regimen involves surgery and platinum-based chemotherapy. Although the exact etiology of ovarian cancer is unknown, there are several factors that have been found to raise the risk of the illness. Experts understand that DNA alterations, or mutations, occur in ovarian cancer-causing cells when they originate within or close to the ovaries. The instructions that...
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