Posted by admin on Jun 1, 2013 in |
Dendrimers are highly branched and reactive three-dimensional macromolecules, with all bonds emanating from a central core. Compared with traditional linear polymers, Dendrimers have much more accurately controlled structures, with a globular shape, a single molecular weight rather than a distribution of molecular weights, and a large number of controllable ‘peripheral’ functionalities. All these versatile features of dendrimers have made their application in various areas like Biomimetic, Pharmaceutical drug delivery, Gene delivery, Chemotherapy and Diagnostics very attractive. This review briefly discusses different types of dendrimers with their structures and their methods...
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Posted by admin on Jun 1, 2013 in |
From this article, we get the knowledge about the transdermal patch, transdermal drug delivery system and anatomy of the skin. Now-a-days transdermal drug delivery, system is widely used in much disease. So, this article gives the knowledge about pre transdermal system, post transdermal drug delivery system and future of transdermal drug delivery systems and examines the benefits and limitations of current transdermal drug delivery system. We also get information about different drugs’ transdermal patch which was approved by FDA in different years. There is a difference in design of transdermal patch in which mainly design of liquid reservoir system and adhesive matrix system and system how it works. Here in first generation, mainly reservoir system is used, while in second generation mainly iontophoresis and chemical penetration enhancers can be used however in third generation thermal ablation as a penetration enhancer can be used. These all designs include in different generation which shows what is the novel approach occurs as the time gone. So, these guide to basic and modified...
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Posted by admin on Jun 1, 2013 in |
Drug addiction represents one of the major medical, social, and economic burdens of human behavior. Opioids are powerful relievers; use of opioids for the treatment of pain has been associated with the potential disadvantages including development of tolerance, dependence. There are seven stages involved in opioid addiction. Identification of glial-mediated mechanism inducing opioid side effects includes cytokine receptor, κ-opioid receptor, NMDA receptor and toll like receptor (TLR). Glial activation through TLR leading to the release of proinflammatory cytokines acting on neurons which is important in the complex syndrome of opioid dependence and withdrawal. Moreover, newer agents targeting these glial cell activation such as AV411, AV33, SLC022 and older agents for other diseases conditions such as minocyclline, pentoxifylline, all show varied but promising profiles for providing significant relief from opioid side...
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Posted by admin on Jun 1, 2013 in |
Boswellia serrata Roxb. is known as kundur in Unani medicine, belongs to the family Burseraceae. The plant is widely distributed in India, it occurs in dry hilly forests of Rajasthan, Madhya Pradesh, Gujarat, Bihar, Assam, Orrisa, central peninsular regions of Andhra Pradesh etc. In ancient times Hindus, Babylonians, Persians, Romans, Chinese, Greeks and the people of old American civilization used its resin primarily for embalming and for its incense in cultural functions. This herb is mentioned in traditional Unani texts as an effective remedy for bronchitis, asthma, cough, cardiovascular diseases, diarrhea, dysentery, ringworm, boils, fevers (antipyretic), skin and blood diseases, mouth sores, vaginal discharges, etc. The qualitative phytochemical study of this plant extract indicates the presence of tannin, pentosans, lignin, holocellulose, β-sitosterol, and both volatile and non-volatile oils. The volatile oils of resin such as cadinene, eleneol, gereniol, linalool, β-pinene, phenols, terpenyl acetate, bornyl acetate etc and non votalie oils like diterpene alcohol serratol, α- and β-amyrin and eight triterpenic acids, viz., Boswellic acid. It chiefly possesses anti-arthritic, anti-inflammatory,...
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Posted by admin on Jun 1, 2013 in |
Solid dispersions, defined as the dispersion of one or more active pharmaceutical ingredient in a carrier at solid state and an efficient technique to improve dissolution of poorly water-soluble drugs to enhance their bioavailability. Poor water solubility is one of the major problems for the various types of drugs and various approaches have been introduced for the enhancement of solubility of such drugs. The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. The number of poor water soluble compounds has dramatically increased. Currently only 10-12% of new drug candidates have both high solubility and high permeability. More than 60-65% of potent drug products suffer from poor water solubility. Solid dispersions have attracted considerable interest as an efficient means for improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. Compared to conventional formulations such as tablets or capsules, solid dispersions which can be prepared by various methods have many advantages. Few of the aspects are to be considered for...
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