Posted by admin on Feb 28, 2025 in |
Malnutrition continues to be a significant public health concern, affecting the survival, growth, and well-being of both current and future generations, especially in developing nations such as India. This study examines the intricate characteristics of malnutrition, including insufficient and excessive nutrition, with a major emphasis on protein-energy malnutrition (PEM) in children, the high occurrence of stunting, wasting, and underweight conditions in children, based on data from the National Family Health Survey (NFHS-5) and multiple studies conducted in Jaipur. It emphasizes the notable gender discrepancies and socio-economic factors contributing to these conditions. Ayurveda emphasizes the significance of maintaining a well-balanced diet (Aahara) and recognizes the influence of Vata dosha in disturbing the process of digestion and absorption of nutrients, resulting in ailments like Karshya, Balashosha, and associated disorders. Ayurvedic therapies prioritize dietary alterations, herbal supplementation, and lifestyle adjustments to restore physiological equilibrium and enhance overall well-being. This article suggests incorporating Ayurvedic concepts into current government nutrition initiatives, such as POSHAN Abhiyaan and Pradhan Mantri Matru Vandana Yojana (PMMVY). Concrete suggestions encompass...
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Posted by admin on Jan 31, 2025 in |
The Expanded Programme on Immunization (EPI), launched in 1974, is the world’s major vaccination program against vaccine preventable diseases. Despite progress, the program’s success, measured through coverage rates, has recently stalled, especially in low-income countries where access to vaccines remains challenging. EPI’s effectiveness relies heavily on the Immunization Supply Chain, but technological changes and new vaccine introductions have strained these systems, leading to stock-outs and risks due to outdated cold chain equipment. These challenges cause health disparities and undermine immunization coverage, particularly in contexts constrained by resource scarcity. Launched in 2010, Effective Vaccine Management (EVM) initiative addresses some of these concerns by improving and evaluating vaccine supply chain systems at large scale globally. This study, utilizing the EVM 2.0 to analyse data from 57 nations that are in the public domain between 2019 and 2023 using the EVM 2.0 assessment tool, offers an analysis of Immunization Supply Chain. The review shows the composite score of 73 which depicts an average performance overall with strengths in financial, human and managerial...
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Posted by admin on Jan 31, 2025 in |
The majority of novel chemical entities getting discovered are having low water solubility and it must be addressed to distribute the drug more effectively. SMEDDS, a lipid-based drug delivery approach, is thought to boost oral absorption of less hydrophilic drugs. Surfactants are the major excipients used in SMEDDS as they are responsible for the emulsification process. The two main criteria while choosing a surfactant should be HLB and safety. A high emulsifying property is what the emulsifier employed in SMEDDS formulation is ought to have. The high hydrophilicity and HLB value of a surfactant guarantees instant oil-in-water droplet production and fast dispersion of formulation in aqueous fluids. The most frequently advised and preferred surfactant type used in SMEDDS are non-ionic surfactants with a rather high HLB value. A high concentration of surfactant is required for a stable self – micro-emulsifying drug delivery systems and they usually contain surfactant concentrations in the range of 30% to 60% w/w. Surfactants that are suitable for use in pharmaceuticals include kolliphor RH40, Cremophor® RH40,...
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Posted by admin on Jan 31, 2025 in |
Autoimmune hepatitis (AIH) is a chronic liver disease characterized by immune system dysfunction, elevated gamma globulins, and specific auto antibodies. It arises from genetic predisposition, environmental triggers, and immune dysregulation, and is typically managed with immunosuppressive therapy. The research highlights AIH risks, including disease recurrence and complications from vaccinations like COVID-19 and Hepatitis A, underscoring the need for tailored management and ongoing patient monitoring. We present a rare case of AIH in an adult male with delayed diagnosis. Initially, he experienced jaundice at 14 and managed it with alternative medicine. At 32, he was diagnosed with jaundice, liver dysfunction, and portal hypertension, which progressed despite treatment. By 34, he was diagnosed with decompensated chronic liver disease related to AIH at a government tertiary care hospital. The study explores novel diagnostic approaches, such as neuro-fuzzy cognitive maps, serum biomarkers like GDF15, and gene expression profiling to improve early detection. It also discusses emerging therapeutic strategies, including cytokine modulation and immunoproteasome inhibition, to optimize treatment outcomes. With further research, these methods...
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Posted by admin on Jan 31, 2025 in |
Psychrozymes, a diverse set of cold-active enzymes produced by psychrophiles including β-galactosidases, pectinases, and amylases which are examined for their specific benefits across various food processing domains. An in-depth exploration of psychrophiles in cold fermentation processes reveals their pivotal role in shaping the sensory attributes of fermented foods and beverages. Psychrophiles contribute to nuanced flavour profiles and distinctive textures, positioning them as catalysts for innovation in cold fermentation. Psychrophiles in bio-preservation have led to advancements in cold-chain technologies, which extend the shelf life of refrigerated and frozen foods while minimizing energy consumption, providing sustainable solutions. This paper highlights food biotechnological applications, showcasing psychrophiles role in advancing brewing and bioconversion of agricultural byproducts, their influence in baking, flavouring, meat tenderization, cheese production, and animal feed formulation. Additionally, this paper also deals with the mechanism and factors contributing to survival of psychrophiles in cold temperatures. Psychrophiles transcend traditional boundaries, impacting sensory attributes and nutritional profiles across a variety of food...
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