Posted by admin on Jul 1, 2013 in |
Dihydrofolate reductase (DHFR) was discovered in the late 1950s by investigators searching for folate-dependent enzymes involved in 1-carbon metabolism, with its already known application as anti-cancer and as antibiotics. This study focuses on structure of Dihydrofolate, its interaction with specific amino acids, mechanism of DHFR catalysis. The reason of study was to focus on compounds which can inhibit DHFR and has applications as antifungal agents, antimalarial agents, ant tuberculosis agents, for Leishmaniasis and Trypanosomiasis treatment. Also, to find out the reason of resistance to antifolates and ways to overcome them, recent drugs under each class of agents and drugs under clinical...
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Posted by admin on Jul 1, 2013 in |
The medicinal plants are widely used by traditional medical practitioners for curing various diseases in their day to day life. In traditional system of medicine different parts of Phyllanthus reticulatus are used for curing various ailments. Bark is used as astringent and diuretic. Leaves are antidiarrheal and roots are used for asthma. Fruit of the plant is used in inflammation. Phyllanthus reticulatus has been proved to show antidiabetic, antiviral, anticancer, antiplasmodial, hepatoprotective, antibacterial and anti-inflammatory activities. The plant contains tannic acid, terpenoids, flavonoids, phenolic compounds and steroids as main chemical constituents. This article aims to provide a comprehensive review on the phytochemical and pharmacological aspects of this plant. The innumerable medicinal properties and therapeutic uses of Phyllanthus reticulatus prove its importance as a valuable medicinal...
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Posted by admin on Jul 1, 2013 in |
Biosensors have revolutionized the way of diagnosis by allowing detection of diseases at earlier stage & detection of altered amount of biomarkers in the body. All biosensors usually involve minimal sample preparation as the biological sensing component is highly selective for the analyte concerned. There are numerous biosensors available now-a-days such as electrochemical biosensors, optical biosensors, DNA biosensors, microbial biosensors, mass based biosensors, calorimetric biosensors etc, which enable reliable & fast detection of analyte & provide accurate results at earliest. Biosensors have many uses in clinical analysis, general health care monitoring, veterinary and agricultural applications, industrial processing and monitoring, and environmental pollution control. Biosensor technology has the potential to provide fast and accurate detection, reliable imaging of cancer cells, and monitoring of angiogenesis and cancer metastasis, and the ability to determine the effectiveness of anticancer chemotherapy...
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Posted by admin on Jul 1, 2013 in |
Combinatorial chemistry is a new methodology by which we can simultaneously synthesize a number of possible compounds that could produce simultaneously a very large number of compounds, called libraries.Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but often structurally related molecules or materials. Combinatorial chemistry is especially common in CADD (Computer aided drug design) and can be done online with web based software, such as Molinspiration.In the past, chemists have traditionally made one compound at a time. For example compound A would have been reacted with compound B to give product AB, which would have been isolated after reaction work up and purification through crystallization, distillation, or chromatography. In contrast to this approach, combinatorial chemistry offers the potential to make every combination of compound A1 to Am with compound B1 to Bn. Although combinatorial chemistry has only really been taken up by industry since the 1990s, its roots can be seen as far back as the 1960s when a researcher at...
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Posted by admin on Jul 1, 2013 in |
Preservatives prolong the shelf-life of food, cosmetics and pharmaceuticals by preventing their spoilage. Antimicrobials such as nitrites, nitrates, benzoates and sulfur dioxide destroy or delay the growth of bacteria, yeast and molds. Anti-oxidants such as butylated hydroxy toluene (BHT), butylated hydroxy anisole (BHA), and propyl gallate slow or stop the breakdown of fats and oils. Anti-enzymatic preservatives such as citric and erythorbic acids block the enzymatic processes such as ripening occurring in foodstuffs even after harvest. Natural substances like salt, sugar, vinegar and spices have been used as preservatives since time immemorial. The majority of preservatives used today are artificial rather than natural. Several of them are toxic and several others have potentially life-threatening side effects. Researchers have reported that artificial preservatives such as nitrates, benzoates, sulfites, sorbates, parabens, formaldehyde, BHT, BHA and several others can cause serious health hazards such as hypersensitivity, allergy, asthma, hyperactivity, neurological damage and cancer. Research has proven that several natural preservatives obtained from plants, animals, microbes and minerals contain antioxidant, antimicrobial and antienzymatic properties. Extracts...
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