Posted by admin on Jul 1, 2013 in |
Carissa spinarum L. is a small spinous evergreen shrub growing throughout India in dry regions.The plant used locally in Indian and Chinese system of medicines to cure various diseases. Carissa spinarum has also been used in the Ayurvedic medical system because of its therapeutic effects against liver disease, epileptic disease, microbial disease, cytotoxic, viral diseases.The isolated metabolites and crude extract have exhibited a wide of in vitro and in vivo pharmacological effect, including antioxidant, antimicrobial, antiviral, anticonvulsant, anticancer, antiarthritic, antihelmintic, cytotoxic activity. A chemical study of this plant was then initiated, and this led to the isolation of 12 compounds, including a coumarin, two cardiac glycosides and nine lignans. These isolated compounds were evaluated for several biological activities, including antiherpetic, cytotoxic, antioxidant and antibacterial effects.A shrub, Carissa spinarum have emerged as a good source of the traditional medicines for the treatment of inflammation, arthritis, microbial infection, epilepsy, viral infection, cancer disease. Pharmacological results have validated the use of this species in the traditional medicines. Some bioassays are difficult reproduce...
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Posted by admin on Jul 1, 2013 in |
The article attempts to discuss the issues associated with technology transfer in the pharmaceutical industry. A major decision focuses on that point where the idea or process is advanced from a research- oriented program to target toward commercialization. The success of any program is highly dependent on the effectiveness of the communication preceding its implementation. The ultimate goal for successful technology transfer is to have documented evidence that the manufacturing processes for drug substances and drug product, respectively, are robust and effective in producing the drug substances and drug product complying with the registered specifications and Good Manufacturing Practice requirements. The Pharmaceutical Technology Transfer activities are to transfer product and process knowledge between development and manufacturing, and within or between manufacturing sites to achieve product realisation. This knowledge forms the basis for the manufacturing process, control strategy, process validation approach and ongoing continual improvement. To take all the gathered knowledge and use it as the basis for the manufacturing control strategy, the approach to process qualification and on-going continuous...
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Posted by admin on Jun 1, 2013 in |
Anaemia associated with chronic kidney disease (CKD) affects the overall health of the patients leading to increased morbidity and mortality. Erythropoietin stimulating agents (ESAs) have been the standard of care for the treatment of such patients since last 20 years. These agents have the potential to increase mean haemoglobin levels in both pre dialysis and dialysis maintenance phases hence lowering the cardiovascular complications and all-cause mortality. After epoetin and darbepoetin, Peginesatide, a novel pegylated erythropoietin (EPO) mimetic agent has recently been approved in March, 2012. Its better stability, once a month administration and non-immunogenicity makes this a preferable ESA. This review will elucidate the available evidence on efficacy and safety of this drug after analyzing various studies conducted in patients with renal anaemia. Searches of Pubmed, Cochrane database, Medscape, Google and clinicaltrial.org were made for terms like peginesatide, CKD, ESA and renal...
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Posted by admin on Jun 1, 2013 in |
Dendrimers are highly branched and reactive three-dimensional macromolecules, with all bonds emanating from a central core. Compared with traditional linear polymers, Dendrimers have much more accurately controlled structures, with a globular shape, a single molecular weight rather than a distribution of molecular weights, and a large number of controllable ‘peripheral’ functionalities. All these versatile features of dendrimers have made their application in various areas like Biomimetic, Pharmaceutical drug delivery, Gene delivery, Chemotherapy and Diagnostics very attractive. This review briefly discusses different types of dendrimers with their structures and their methods...
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Posted by admin on Jun 1, 2013 in |
From this article, we get the knowledge about the transdermal patch, transdermal drug delivery system and anatomy of the skin. Now-a-days transdermal drug delivery, system is widely used in much disease. So, this article gives the knowledge about pre transdermal system, post transdermal drug delivery system and future of transdermal drug delivery systems and examines the benefits and limitations of current transdermal drug delivery system. We also get information about different drugs’ transdermal patch which was approved by FDA in different years. There is a difference in design of transdermal patch in which mainly design of liquid reservoir system and adhesive matrix system and system how it works. Here in first generation, mainly reservoir system is used, while in second generation mainly iontophoresis and chemical penetration enhancers can be used however in third generation thermal ablation as a penetration enhancer can be used. These all designs include in different generation which shows what is the novel approach occurs as the time gone. So, these guide to basic and modified...
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