This paper reviews the pharmacological importance of citrus fruits. Citrus fruits are used for various pharmacological importance. According to literature the citrus fruit possess anti-cancer, antimicrobial, antioxidant, antiulcer, anti-inflammatory, and hypolipidemic and hepatoprotective...
Read MoreEvaluation of herbs for anti-fertility effects has been in progress worldwide for several decades to identify effective and safe substances for control of population explosion. This population explosion will have negative impact on our economic policies and would simultaneously misbalance our socio-economic infrastructure. Family planning has been promoted through several methods of contraception, but due to serious adverse effects produced by synthetic steroidal contraceptives, attention has now been focused on indigenous plants for possible contraceptive effect. Although contraceptives containing estrogen and progesterone are effective and popular, the risks associated to the drugs have triggered the need to develop newer molecules from medicinal plants. Hence, there is a need for searching suitable product from indigenous medicinal plants that could be effectively used in the place of...
Read MoreNeedle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle. Needle-free technology offers the very obvious benefit of reducing patient concern about the use of needle. Needle free injection gives very effective injections for a wide range of drugs and bioequivalent to syringe and needle, results in less pain, and is strongly preferred by patients. Additional benefits include very fast injection compared with conventional needles and no needle disposal issues. Not only it can benefit the pharmaceutical industry in increasing product sales, it has the added potential to increase compliance with dosage regimens and improved outcomes. Today, they are a steadily developing technology that promises to make the administration of medicine more efficient and less...
Read MoreTablet is the most popular among all dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing; however in many cases immediate onset of action is required than conventional therapy. There are novel types of dosage forms that act very quickly after administration. The basic approach used in development tablets is the use of superdisintegrants like Cross linked carboxymelhylcellulose (Crosscarmellose), Sodium starch glycolate (Primogel), Kollidon Cl etc. which provide instant disintegration of tablet after administration. A new dosage form allows a manufacturer to extend market exclusivity, while offering its patient population a more convenient dosage form or dosing regimen. In this regard, immediate release formulations are similar to many sustained release formulations that are now commonly...
Read MoreThe act of emesis is controlled by the vomiting centre in the medulla, which integrates afferent input from the vestibular system, the chemoreceptor trigger zone (CTZ), the cortex and the gut. Nausea and vomiting induced by several cancer chemotherapy agents is often the most distressing side effect of treatment. The mechanism of action of antiemetic is related to blockage of various type of receptor located in various region of various organ of the body parts. Various drugs are classified under antiemetic like Ondansetron, Granisetron & Metochlopramide etc. A critical review of the studies of aprepitant (a new NK1 receptor antagonist) and of palonosetron (a 5-HT3 receptor antagonist with a longer half-life) presented in this article. Aprepitant combined with dexamethasone and a 5-HT3 antagonist significantly increase the control of acute emesis with respect to dexamethasone. Palonosetron showed superior or similar efficacy to Ondansetron and dolasetron in patients submitted to moderately emetogenic chemotherapy Certain side effects arise due to excessive use of antiemetic like twitching, flushing of skin, headaches, tiredness, indigestion...
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