Posted by admin on May 1, 2013 in |
Rapid rising population has caused serious problems in the economic growth and all around human development especially in developing countries like India. Our future well-being depends on increased access to family planning and reproductive health services and decreased consumption by people. Family planning has been promoted through several methods of contraception. But due to series adverse effects produced by synthetic steroidal contraceptives, attention has now been given to indigenous plants for possible contraceptive effects. Thus there is a need of replace these agents by plants. The investigation of plant constituents with development of an effective, reversible and safe male contraceptive represents a potential alternative approach to birth control from the existing available methods. This review concentrates on those recent advances in science and technology that offer possible inroads for shifting the paradigm for male-based contraception. This review presents updated information gathered on scientifically proved medicinal plant (Withania Somnifera) and their more than 50 secondary metabolites might be can use as male contraceptive agents and other biological activity. The aim...
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Posted by admin on May 1, 2013 in |
Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors, and play a central role in insulin sensitivity, lipid metabolism, and inflammation. PPAR -γ appears to improve glycaemic control by increasing peripheral insulin sensitivity and reducing hepatic glucose production, thereby helping to preserve beta-cell function. However, they have modest beneficial effects on lipid parameters. It has been observed that fibrate drugs which activate PPAR- α, produce significant improvements in dyslipidaemia and decrease atherosclerotic lesions, but do not affect glycaemia. Theoretically, a compound targeting both α and γ PPARs simultaneously, might combine the benefits of thiazolidinediones (TZDs) and fibrates. Hence, there is a resurgence of interest in the development of new antidiabetic drugs that combine the insulin-sensitizing effects of PPARγ activation with the additional lipid-modifying activity of the other PPAR subtypes. Compounds that act on both receptors may represent an attractive treatment option, provided that the potential to improve both glycemic and lipid parameters can be achieved within the same therapeutic window in order to minimize the incidence of PPAR-related side effects....
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Posted by admin on May 1, 2013 in |
There are up to 25000 genes encoded by our genome however among them only some are being expressed on mass level. Some of these important genes are; ABO genes located at chromosome number 9, ALB genes located at chromosome number 4, BCL-2 genes located at chromosome number 18, CCR-5 genes located at chromosome number 3, CD4 genes located at chromosome number 12, CD8 genes located at chromosome number 2, IL10 genes located at chromosome number 1, IL2 genes located at chromosome number 4 and INS genes located at chromosome number 11. These above mentioned genes are important in the proper functioning of the body and any mutation in them could lead to different genetic...
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Posted by admin on Apr 1, 2013 in |
Crinum is a well-known traditional herb belongs to family Amaryllidaceae. Worldwide, different Crinum species are commonly used to treat various conditions due to their excellent medicinal values. Members of this genus are also best known biofactories for the unique Amaryllidaceae alkaloids. Due to the significant phytoconstituents produced by this plant as well as their therapeutic potentials, many Crinum species have been subjected to extensive chemical, cytological and pharmacological investigations. This part of our comprehensive review work on the chemical and biological profiles of Crinums describes the results of biological and toxicological studies conducted on different species. In addition, general analytical conclusions as well as some suggestions for future phytochemical and biological work on Crinums are...
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Posted by admin on Apr 1, 2013 in |
One-third of eukaryotic proteins are associated with membranes and these membrane proteins (MP) represent approximately 50% of pharmacological targets. Researchers are therefore nursing the hope of achieving a higher percentage of about 80% in the near future. The only bottleneck to achieving this target is the experimental challengers associated with the production, purification and crystallization at reasonable cost. Expression of protein in E. coli is now very popular, because it is easy to use and also comes with low operational cost. But membrane proteins have been difficult to produce in E. coli. The membrane proteins (MP), G-protein coupled receptors (GPCRs) represent the major class of potential drug targets but probably the most difficult class of MPs to bring to three-dimensional studies. This review paper therefore sought to bring to the fore some of the techniques employed by researchers to improve the quality and quantity of GPCR expressed in E. coli. A literature search on the effective expression of some important members of the GPCR family in E. coli was...
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