Posted by admin on Dec 31, 2024 in |
The human microbiota, a complex assembly of microorganisms residing in various bodily niches, plays a critical role in health and disease. Historically, traditional medicine implicitly recognized the importance of the microbiota through the use of fermented foods and herbal remedies, which we now understand can influence the gut microbial composition and contribute to a robust immune system and improved metabolic processes. In the contemporary landscape, the role of microbiota has been significantly expanded by modern science. Advancements in genomic and bioinformatics tools have unraveled complex interactions between human health and microbiota, particularly in understanding the impact of modern pharmacological agents. Recent studies have highlighted the dual-edged effects of broad-spectrum antibiotics, which, while combating pathogens, also disrupt commensal microbial communities, potentially leading to dysbiosis and associated health conditions. Furthermore, emerging research into the gut-brain axis suggests profound implications of microbiota management in neurological disorders, signifying a shift towards microbiota-centered therapeutic strategies. This review traces the journey of microbiota research from its historical roots to its current innovations and potential future...
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Posted by admin on Dec 31, 2024 in |
Several techniques were applicable to increase the aqueous solubility’s of poorly water-soluble drugs. Hydrotropy technique is one of them. In the present study, the hydrotropic agent has been used as a Solubilizing agent to solubilize BCS Class-II drugs that is poorly water-soluble drugs. Hydrotropy is an increase in the solubility of a solute in water by adding an agent termed hydrotrope. Increasing the solubility of various drugs in water is a very important aspect of hydrotropy. Various formulations need some substances or drugs to solubilize in water. Also, it is very important to analyze the drug formulations. Hydrotropy can be incorporated with spectrophotometric and chromatographic analysis for accurate, rapid, easy and precise analysis. The hydrotropic agent did not interfere with spectrophotometric determination. Most of the investigations concluded that hydrotropy was the most efficient tool for solubility enhancement. Solubility enhancement over 100-fold was observed in some investigations. Hydrotropic agents possess high industrial demand. This review article also highlights the applications and future prospects with the employment of hydrotropes and hydrotropic...
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Posted by admin on Dec 31, 2024 in |
Rosmarinic acid, a key component of Rosemary (Rosmarinus officinalis), holds significant promise as an adaptogen in herbal medicine, offering a natural remedy to counteract stress’s wide-ranging impacts on health. This abstract explores rosmarinic acid’s pharmacological activities, emphasizing its modulation of the hypothalamic-pituitary-adrenal (HPA) axis, regulation of neurotransmitters, antioxidant and anti-inflammatory effects, and enhancement of mitochondrial function. Integrating insights from traditional medicine like Ayurveda and Traditional Chinese Medicine (TCM), alongside modern scientific validation, highlights Rosemary’s evolution from culinary herb to medicinal powerhouse. Structurally, rosmarinic acid’s stability, facilitated by its ester-bonded dual phenolic rings, supports its therapeutic efficacy. Experimental studies underscore its ability to reduce cortisol levels, bolster stress resilience, stabilize mood, and enhance cognitive function by influencing neurotransmitter systems. Moreover, its robust antioxidant and anti-inflammatory properties, validated across in vitro, animal models, and clinical trials, suggest potential applications in preventing oxidative stress and inflammation-linked diseases. By promoting mitochondrial biogenesis and activating the AMPK pathway, rosmarinic acid enhances cellular energy production, further fortifying resilience to stressors. In summary, rosmarinic acid emerges...
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Posted by admin on Dec 31, 2024 in |
Hyperpigmentation is a skin complaint where black patches or spots appear on skin. It affects a large percentage of the human population. Cosmetics that naturally lighten the skin have been shown to be both safe and effective for treating hyperpigmentation. To achieve a lighter skin appearance, skin lightening goods are commercially accessible for cosmetic resolutions. They’re also utilised in the clinic to treat pigmentary disorders like melasma and post-inflammatory hyperpigmentation. Various stages of melanin content in the skin are affected by whitening agents. The finding demonstrates that numerous bioactive substances have anti-oxidant and anti-inflammatory properties in addition to tyrosinase inhibition, melanosome transfer inhibition, and other mechanisms that affect the melanin production pathway. Many of them have been identified as good inhibitors of tyrosinase, a central enzyme in the process of melanogenesis. Others stop this enzyme from maturing or from transporting pigment granules (melanosomes) from melanocytes to keratinocytes. We present an overview of whitening products obtained from natural sources that may reduce skin pigmentation by interfering with pigmentary processes in...
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Posted by admin on Dec 31, 2024 in |
The aim of this paper is to give a systematic overview on the morphology, ethnobotanical uses, phytochemistry and pharmacological activities of Anogeissus latifolia. It focuses to identify the research gap and further proceed to experimental studies. It may also help out the researcher for further detailed studies. A systematic search criterion of literature was carried out by computing Google scholar, Pub med, NCBI, open access peer reviewed journals and web of science including some unpublished sources. The plant is known to possess wide range of pharmacological activities like Anthelmintic, Thrombolytic, Antiasthmatic, Anticonvulsant, Anticancer, Antidiabetic, Antibacterial, Antipyretic, Antioxidant, Antiulcer, Analgesic, Anti-inflammatory, Hepatoprotective and Wound healing activity. Limited numbers of phytoconstituents were reported like tannins, triterpenoids, ellagic acid, monosaccharides, β- sitosterol from the plant that shows biological activities with diverse ethnobotanical uses. The present review also explores the traditional medicinal uses of the tree, highlighting its role in treating various ailments and wide use of its gum in pharmaceuticals, food processing and...
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