Posted by admin on Oct 1, 2012 in |
The parenteral administration route is the most effective and common form of delivery for active drug substances with poor bioavailability and the drugs with a narrow therapeutic index. Drug delivery technology that can reduce the total number of injection throughout the drug therapy period will be truly advantageous not only in terms of compliance, but also to improve the quality of the therapy and also may reduce the dosage frequency. Such reduction in frequency of drug dosing is achieved by the use of specific formulation technologies that guarantee the release of the active drug substance in a slow and predictable manner. The development of new injectable drug delivery system has received considerable attention over the past few years. A number of technological advances have been made in the area of parenteral drug delivery leading to the development of sophisticated systems that allow drug targeting and the sustained or controlled release of parenteral...
Read More
Posted by admin on Oct 1, 2012 in |
Vitamin B12 plays an important role in building of genetic material, in development of normal red blood cells and in maintenance of nervous system. Major deficiency symptoms of Vitamin B12 include anemia and neurological disorders. The daily recommended intake of vitamin B12 for an adult is 1.5μg a day. Eating a diet containing required amount of vitamin B12 is the best way to treat the conditions associated with its low level. Vitamin B12 found only in animal based foods such as meats, liver, kidney, fish, eggs, milk and milk products, oysters and shellfish. Hence, vegetarians are more likely to have low level of Vitamin...
Read More
Posted by admin on Oct 1, 2012 in |
Diabetes mellitus is a lifestyle disorder that is rapidly becoming a major threat to populations all over the globe. Over the past 30 years, the status of diabetes has changed from being considered as a mild lifestyle disorder of the elderly to one of the major causes of morbidity and mortality, affecting people of all ages. India is slated to be the diabetic capital of the world, with 50.8 million diabetics. There seems to be a renewed interest in herbal medicines across the world today and plants are a powerhouse of sources for antidiabetic principles. Hence, a review on the antidiabetic plants has been done and the plants with antidiabetic principles isolated have been tabulated. Electronic searches were conducted in numerous databases and relevant journals. Sources also included various books and newspaper articles. Hand searches were also carried out in additional journals and secondary references. Researchers in the field of Ayurveda, Siddha, Unani and Homeopathy were consulted for access to ongoing research and various references. Molecular docking studies were...
Read More
Posted by admin on Oct 1, 2012 in |
Crinums occupy an important position within plants of family Amaryllidaceae, and many of them have been broadly used in traditional and ethnomedicines throughout the world. Due to their richness in bioactive phytoconstituents, Crinums have been subjected to extensive chemical, cytological and pharmacological investigations that focused chiefly on their alkaloidal content. Continuing our appraisal about the results of phytochemical, biological and toxicological studies on Crinums and after considering lycorine- and crinine-alkaloids as the major classes in its two previous parts; the current part of our review work draws attention to members of the other less common alkaloidal classes as well as the new types that are not common in the...
Read More
Posted by admin on Oct 1, 2012 in |
In the past three decades, monoclonal antibodies have become increasingly important class of disease modifying drugs for numerous indications including cancer, inflammatory diseases, and viral infections. Antibody therapy can be used in a variety of ways either alone or combination with cytotoxic compounds. Molecular antibody engineering technologies coupled with advances allow the generation of better antibodies with fully human sequence and optimized function thereby increases the antibody efficacy. Recombinant antibodies and its fragments have been fused to radioisotopes, drugs, toxins, enzymes and antibody-directed pre-targeting followed by prodrug activation (ADEPT) has an alternative strategies for promising therapy of cancer. Various monoclonal antibodies (mabs) have been developed and approved as immunotherapeutic agents. This review briefly describes new development of antibodies and immunoconjugates for broader...
Read More
