Posted by admin on Aug 1, 2012 in |
Peptic ulcer is a worldwide health problem because of its high morbidity, mortality and enormous financial implication. An estimated 15,000 deaths per year occur as a consequence of complicated PUD.A large number of drugs for peptic ulcer disease are available in mainstream medicine but they are associated with numerous side effects like arrhythmias, impotence, gynaecomastia and haematopoietic changes and the recurrence is also very common. In recent times, focus on plant research has increased all over the world and a large body of evidence has been collected to show immense potential of medicinal plants used in various traditional systems. Here, an attempt is made to summarise experimentally proved herbs used in PUD during last...
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Posted by admin on Aug 1, 2012 in |
Modified Release (MR) Formulations have a modification in the release mechanism. Modified release dosage forms are developed by altering drug absorption or the site of drug release in order to achieve predetermined clinical objectives. Modified drug release from dosage forms is complemented by the allied processes of drug design, of dosage administration, and of membrane transport and absorption of drug to the biological site of action.Modified-release drugs have complex formulations that can offer an advantage over standard medication for some patients. Modified-release preparations should only be used where there is a clear clinical advantage over conventional-release preparations. In general, Modified-release preparations should be reserved for specific patients where there is a problem with compliance, effectiveness or side-effects which these preparations could help overcome. Modified–release technologies have become indispensable to resolving critical technical, therapeutic, and marketing challenges, such as improving patience compliance, less dosage timings, better safety, better indications, delivering poorly soluble and poorly absorbable API’s, product differentiation, patent protection, product life-cycle extension, and better margins. Modified-release formulation design can...
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Posted by admin on Aug 1, 2012 in |
Metabolic Syndrome is a cluster of several cardiovascular risk factors that include glucose intolerance, central obesity, dyslipidemia, and hypertension. The public health impact of this syndrome is weighty; given it is a primary risk factor for cardiovascular diseases, obstructive sleep apnea, and type II diabetes. This current plight is further underscored by recently emerging evidence that Metabolic Syndrome is also associated with albuminuria and increasing incidence of chronic kidney disease, Moreover, this relationship persists even after exclusion of individuals with diabetes. Thus, Metabolic Syndrome is an independent risk factor for the development of chronic kidney disease, in the absence of diabetes, and independent of hypertension. ...
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Posted by admin on Aug 1, 2012 in |
Transdermal drug technology specialists are continuing to search for new methods that can effectively and painlessly deliver larger molecules in therapeutic quantities to overcome the difficulties associated with the oral route. Transdermal Drug Delivery System (TDDS) is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. Skin is an effective medium from which absorption of the drug takes place and enters in to circulatory system. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin. The patches have been proved effective because of its large advantages over other controlled drug delivery systems. This review article covers a brief outline of various components of transdermal patch, applications of transdermal patch, their advantages, disadvantages, when the transdermal patch are used and when their use should be avoided, types of transdermal patch, recent techniques for enhancing...
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Posted by admin on Aug 1, 2012 in |
Traditional systems of medicine in India include Ayurveda,Yoga, Naturopathy, Unani and Siddha. Among them Ayurveda, Siddha and Unani systems (ASU) use plants, minerals and animal products as main drugs to cure various ailments. There has been a boom in the usage of ASU drugs and export is appreciably high in the last two decades. ASU drugs may vary in composition and properties, unlike conventional pharmaceutical products, which are usually prepared from synthetic, chemically pure materials by means of reproducible manufacturing techniques and procedures. Counterfeits and drugs of poor quality degrade the clinical effects of ASU drugs. Thus authentication is a critical step for successful and reliable clinical applications and for further experimental studies on ASU drugs. The authentication methods for herbal, mineral and marine products are discussed in detail which broadly include microscopy, spectroscopy, chromatography, chemometry, immunoassays, DNA fingerprinting etc. A simple method like organoleptic characteristics may hold good to authenticate certain drugs but some may require highly sophisticated techniques too, based on the adulterants and similarity in the...
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