Posted by admin on Sep 1, 2012 in |
Angiogenesis is process of new blood vessel formation that occurs under both normal and pathological conditions. In the normal state, two distinct processes can be seen. One utilizes endothelial progenitor cells (EPC) and the second utilizes existing vasculature to generate new vessels. The healthy body controls angiogenesis through a series of “on” (angiogenesis-stimulating growth factors) and “off” (angiogenesis inhibitors) switches. However, the structures formed are often functionally abnormal; possibly due to an imbalance in the angiogenic process Angiogenesis represents an excellent therapeutic target for the treatment of cardiovascular disease. The healing of damaged tissues urgently required the rapid formation of new vessels which is brought about by various growth factors: VEGF, FGF, PDGF, Angiopoitins and Ephrins. Therapeutic angiogenesis is the clinical use of methods to enhance or promote the development of collateral blood vessels in ischemic, thrombotic, atherosclerotic tissue. This new form of treatment is an alternative to high risk percutaneous coronary intervention or coronary artery bypass surgery. There are three major ways to promote angiogenesis: protein therapy (by...
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Posted by admin on Sep 1, 2012 in |
Cervical cancer, a potentially preventable disease, remains the second most common malignancy in women worldwide. Despite the tremendous progress that has been achieved in the screening and management of cervical cancer, there is still a need for clinically relevant prognostic biomarkers to monitor the response of patients to various therapies and to predict the chances of recurrence and recovery. Since cancer recurrence is the most common treatment failure in patients with advanced tumor, increasing knowledge about new biologic markers and better ability to predict risk of cancer recurrence is very important for construction of more effective treatment strategies. The biomarkers, which indicate the response of cancer patients to various therapy, predict response to particular therapies and choose the drug that, most likely to yield a favorable response in a given patient, identify patients with a high probability of adverse effects of a treatment and determine whether a therapy is having the intended effect on a disease and whether adverse effects arise. In this literature study we have done a...
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Posted by admin on Sep 1, 2012 in |
Lantana camara is more popular as toxic weed rather than medicinal plant in most of the countries responsible for infesting pastures, grazing lands, orchards and crops like, tea, coffee, oil palm, coconut and cotton, and reduces the economic viability of the crops. This plant can grow even in extreme harsh climatic conditions of tropical and sub-tropical areas and has become naturalized worldwide as an ornamental plant including India. The stem, root and leaves contain many of the bioactive compounds responsible for various therapeutic applications such as cancers, chicken pox, measles, asthma, ulcers, swellings, eczema, tumors, high blood pressure, bilious fevers, catarrhal infections, tetanus, rheumatism, malaria, antiseptic, antispasmodic, carminative and diaphoretic. Besides this, it has some toxic effect by accidental ingestion among the livestock. Best alternate uses of West Indian Lantana started by the people, as it is difficult to eradicate such as household furniture like tables, chairs etc. are made from the stalks.. Present review indicating that Lantana camara is a versatile ornamental plant species having economic importance and...
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Posted by admin on Sep 1, 2012 in |
The globalization of generic drug manufacturing, supply and testing, and a growing workload that has far outpaced USFDA’s resources has created new challenges. USFDA & Industry propose generic drug user fee to address the need for globalization of the inspection process, and to speed the timely review of generic product applications. The Generic Drug User Fee (GDUF) proposal is agreed by generic industry & USFDA and is focused on three key aims: safety, access, and transparency. Under the program, USFDA will receive nearly $1.5 billion over five years in supplemental funding through generic industry user fees in order to help the agency expedite access to generic drugs, enhance drug quality and safety and ensure inspection parity of both foreign and domestic manufacturing sites. GDUF also will help accelerate the market entry of additional manufacturers of drugs currently in short supply and improve quality, consistency, and availability within the supply chain, further helping to mitigate drug shortages. The GDUF new legislation is a milestone for the generic giants and a...
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Posted by admin on Sep 1, 2012 in |
Validation is an integral part of quality assurance; the product quality is derived from careful attention to a number of factors including selection of quality parts and materials, adequate product and manufacturing process design, control of the process variables, in-process and end-product testing. Recently validation has become one of the pharmaceutical industry’s most recognized and discussed subjects. It is a critical success factor in product approval and ongoing commercialization, facilities and processes involved in pharmaceutical manufacturing process impact significantly on the quality of the products. Process controls are mandatory in good manufacturing practice (GMP). The purpose is to monitor the on-line and off-line performance of the manufacturing process, and hence, validate...
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