Posted by admin on Jul 1, 2012 in |
Neonatal sepsis is associated with increased mortality and morbidity including neurodevelopmental impairment and prolongation of hospital stay. Clinical features of sepsis are non-specific in neonates and a high index of suspicion is required for timely diagnosis. Antibiotics are a very important group of drugs for the sick neonate and have undoubtedly played a role in their improved survival. But they come with a set of risks like other drugs used in critical care which must be carefully considered and weighed against the benefits in any decision to commence antibiotics. Prophylactic antibiotics are not indicated in almost all situations in neonatology. There is high level of evidence to show that they are not useful for the prevention of infection following umbilical vessel or central venous catheterization. Traditionally, the selection of antibiotics for empirical therapy is based on the local policy, and the duration of therapy is decided by the treating physician based on clinical symptoms and blood culture results. In this paper, we discuss briefly about the causative organisms of...
Read More
Posted by admin on Jul 1, 2012 in |
Chalcones are 1, 3-diphenyl-2-propene-1-one, consist of two aromatic rings linked by a three carbon α, β-unsaturated carbonyl system. The chemistry of chalcones has generated intensive scientific studies throughout the world. Especially interest has been focused on the synthesis and biodynamic activities of chalcones. These are considered to be precursors of flavonoids and isoflavonoids. The aim of this review is to summarize chalcones and their diverse pharmacological activities like anticancer, antimicrobial, analgesic and antiviral activities...
Read More
Posted by admin on Jun 10, 2012 in |
Due to various advantages such as high-precision dosing, manufacturing efficiency and patient compliance helped making tablets the most popular dosage forms among all available dosages forms. Compaction, which is an essential manufacturing step in the manufacture of tablets, mainly includes compression (i.e. reduction of volume of the powder under consideration and particle rearrangement) and consolidation (i.e., formation of interparticulate bond to facilitate stable compaction). The success of the compaction process depends not only on the physico-technical properties of drugs and excipients, but also on the instrument settings with respect to rate and magnitude of force transfer. Tablet manufacturing speed and pre/main compression force profile also have an influence on the quality of the final tablet. Mechanical aspects of tablet formation can be studied using, instrumented punches/dies, instrumented tablet punching machines, and compaction simulators. These have potential application in pharmaceutical research and development, such as studying basic compaction mechanism, various process variables, scale-up parameters, trouble shooting problems, creating compaction data library, and fingerprinting of new active pharmaceutical ingredients (APIs) or...
Read More
Posted by admin on Jun 1, 2012 in |
Polypodium vulgare Linn. also called as Bisfaij in Unani system of medicine is a perineal fern growing to a height of 30cm. Polypodium vulgare Linn. rhizome is used in European, American, Chinese, and Unani and Ayurveda traditions. It is claimed to be efficacious in jaundice, dropsy, scurvy and combined with mallows it removes hardness of the spleen. The distilled water of the roots and leaves is considered good for ague (malarial fever), and the fresh or dried roots, mixed with honey and applied to the nose, were used in the treatment of polypus The fresh root is used in the form of decoction, or powder for melancholia and also for rheumatic swelling of the joints. The rhizome extract was found to possess anti-epileptic activity. The ecdysones present in the rhizome (0.07%-1% dry weight)was seen to act topically on a wide variety of arthropods and caused abnormal molting and death, so ecdysone analogues may be useful not only as insecticides but also miticides. The aqueous extract of Polypodium vulgare Linn....
Read More
Posted by admin on Jun 1, 2012 in |
The synthesis of gold nanoparticles has received considerable attention and has been a focus of research due to their high chemical and thermal stability, fascinating optical, electronic properties, and promising applications such as nanoelectronics, biomedicine, sensing, and catalysis. Different physical and chemical methods for gold nanoparticles synthesis are known but these methods are either expensive or are not eco-friendly due to use of hazardous chemicals, stringent protocol used during the process. These drawbacks necessitate the development of nonhazardous and greener methods for gold nanoparticles synthesis. Therefore, there has been tremendous excitement in the study of gold nanoparticles synthesis by using natural biological system. Microorganisms thus play a very important role in the eco-friendly and green synthesis of metal nanoparticles. The inherent, clean, nontoxic and environment friendly ability of eukaryotic and prokaryotic microorganisms, plants system to form the metal nanoparticles is particularly important in the development of nanobiotechnology. This review contains a brief outlook of the biosynthesis of gold nanoparticles using various biological resources, characterization and their potential application in...
Read More
