Posted by admin on Jun 1, 2012 in |
Microbubbles are bubbles smaller than one millimeter in diameter, but larger than one micrometer. Microbubbles designate air or gas filled microspheres suspended in a liquid carrier phase which generally results from the introduction of air or gas. The liquid phase contains surfactants to control the surface properties as well as stability of the bubble. Microbubbles have an average size less than that of RBC’s i.e., they are capable of penetrating even into the smallest blood capillaries & releasing drugs or genes, incorporated on their surface, under the action of ultrasound. Microbubbles in general have a wide variety of applications. However in the biomedical field these are primarily used as diagnostic agents in combination with ultrasound for molecular imaging of various organs and even tumours. These are also proposed for drug and gene delivery to targeted regions in combination with various ligands. Most of the physicians today prefer imaging with ultrasound in combination with microbubbles compared to other diagnostic techniques for low cost and rapidity. They are used in medical...
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Posted by admin on May 1, 2012 in |
Medicines obtained from plant source are known as an herbal medicine, and the herbal medicine are one which make human healthy without causing any of harmful effect. Madhuca Indica is a plant of Indian origin having tremendous therapeutic potential but is not fully utilized. It is hidden from the eyes of the researchers and other botanist. Madhuca Indica has several pharmacological activity, and potential to provide health to the society. It is used as Anti diabetic, antiulcer, hepato protective, anti pyretic, anti fertility, analgesic, anti oxidant, swelling, inflammation, piles, emetic, dermatological, laxative, tonic, anti burn, anti earth worm, wound healing headache and many more problems. Here is a misconception about mahua tree that it is used as liquor and harmful for health, but this is what after the fermentation process, so the present review deals with the general and chemical profile of Madhuca Indica and its economic importance including medicinal and other uses, and tried to emphasize the most potent...
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Posted by admin on May 1, 2012 in |
In general, we know that small intestine is mostly the site for drug absorption but in some cases the drug needs to be targeted to some other sites for absorption due to various factors like any disease condition, degradation related situations, for sustained release of drugs etc. Colon targeted drug delivery is a relatively new concept for the absorption of drugs as it offers near neutral pH. Also it offers long residence time, thereby increasing the drug absorption. The nature of food and enzymes does not affect the drug absorption. Colon has proved to be a site for the absorption of poorly soluble drugs. For the successful targeting of drugs to colon the dosage form should be designed such that it prevents the drug release in upper GIT and releasing it in the colonic region. This review article comprises of the various aspects of colon targeting which we should know before experimenting the technique and their IVIVC using recent evaluation models through x-ray imaging and...
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Posted by admin on May 1, 2012 in |
Oxygen free radicals induce damage due to peroxidation to bio-membranes and also to DNA, which leads to tissue damage, thus cause occurrence of a number of diseases and biochemical disorders. Antioxidants neutralize the effect of free radicals through different ways and may prevent the body from various diseases. Antioxidants may play vital role in the metabolic disorders. India stands with highest percentage of people with diabetes, hypertension and cardiovascular disorders among the world. This may be due to life style, ethnicity, and improper food habits. Hence, the search for effective, non-toxic natural compounds with anti-oxidative potentials has been intensified in recent years. In the present review a brief account of research reports on plants constituents with antioxidant potential were...
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Posted by admin on May 1, 2012 in |
Periodontitis is a common and widespread disease, which occurs due to the pathogenic bacterial infections (like Porphyromonas gingivalis, Bacteroides spp., E. coli, Staphylococcus aureus, S. mutans etc.) established within the gingival sulcus. This condition, when not arrested, will cause formation of periodontal pocket. In order to eliminate or control the disease and arrest further periodontal tissue destruction, periodontal pockets need repeated sub gingival mechanical cleansing. This scaling procedure is unpleasant and painful. Systemic antibiotics have their role to play, but are limited by the duration of treatment and also the availability of the antibiotic at the site of action in sufficient quantity. It is not possible to administer broad spectrum antibiotics at its optimum dosage levels, multiple times over large periods. The spread of drug resistant pathogens is one of the most serious threats to successful treatment of microbial diseases. Down the ages essential oils and other extracts of plants have evoked interest as alternates for bacterial infections. Dental plaque is the main etiological factor of periodontal diseases and...
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